Angiopoietin-like Protein 3 (ANGPTL3) Levels in Thai Hyperalphalipoproteinemic Patients

Presentation Number: MON 509
Date of Presentation: April 3rd, 2017

Waralee Chatchomchuan*1, Weerapan Khovidhunkit2, Siriwong Sathapakorn3 and Suwanna Muanpetch4
1Hormonal and Metabolic Disorders Research Unit and Endocrinology and Metabolism Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, THAILAND, 2Hormonal and Metabolic Disorders Research Unit and Endocrinology and Metabolism Unit, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand, 3Department of Medicine, Queen Savang Vadhana Memorial Hospital, Thai Red Cross Society, Chonburi, Thailand, 4Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Abstract

Abstract

Background

Hyperalphalipoproteinemia (HALP) is primarily caused by mutations in the hepatic lipase and/or cholesteryl ester transfer protein genes (1,2). Angiopoietin-like protein 3 (ANGPTL3) is a metabolic factor that increases HDL-cholesterol levels by inhibiting hepatic lipase (3). We aimed to examine the levels of ANGPTL3 in Thai subjects with HALP.

Methods

Ninety ambulatory subjects with HDL-cholesterol level ≥ 100 mg/dl (HALP group) and ninety healthy matched-case controls were recruited. Secondary causes of HALP were excluded. Clinical characteristics and lipid profiles were examined. Plasma ANGPTL3 levels were measured by ELISA.

Results

In the HALP group, ninety-one percent were female with the mean age of 59±11 years. The mean HDL-cholesterol levels were significantly higher in the HALP group compared with those in the control group (99±17 vs. 51±6 mg/dl, p<0.001). The mean triglyceride levels and LDL-cholesterol levels were lower in the HALP group (73±31 vs. 123±50 mg/dl, p<0.001 and 131±35 vs. 144±34 mg/dl, p=0.018, respectively). The mean ANGPTL3 levels were significantly higher among the HALP patients (297±112 vs. 230±100, p<0.001). There was a significant correlation between HDL-cholesterol levels and ANGPTL3 levels in both groups (r=0.3, p<0.001).

Conclusion

ANGPTL3 levels were significantly higher in HALP patients, suggesting that ANGPTL3 may be causally related to HALP in Thai subjects.

 

Nothing to Disclose: WC, WK, SS, SM