β2-Adrenergic Receptor Control of Endosomal PTH Receptor Signaling Via Gβγ

Presentation Number: SAT 358
Date of Presentation: April 1st, 2017

Frederic Jean-Alphonse* and Jean-Pierre Vilardaga
University of Pittsburgh, Pittsburgh, PA

Abstract

Cells express several G protein-coupled receptors (GPCRs) at their surfaces transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrated signaling response induced by distinct GPCRs is thus required. Here we found that the b2-adrenergic receptor, which induces short cAMP response, prolongs nuclear cAMP and PKA activation by promoting endosomal cAMP production in PTH receptor signaling through the stimulatory action of Gbg subunits on adenylate cyclase type 2

 

Nothing to Disclose: FJ, JPV