Adiponectin and insulin resistance are independently associated with apolipoprotein B/A1 ratio in metabolic syndrome

Presentation Number: MON-860
Date of Presentation: June 17th, 2013

Jong Suk Park*1, Chul Woo Ahn1, Kyung Rae Kim1, Shinae Kang1, Tae Woong Noh2, Min Kyung Kim1, Jiyoon Ha1, Haeri Baek1, Chanhee Kyung1 and Sohee Kim1
1Gangnam Severance Hospital, Seoul, Korea, Republic of (South), 2Gangnam Severance Hospital, Seoul

Abstract

Recent studies indicate that apolipoprotein B to A-1 ratio (apo B/A-1) is a predictor of atherosclerotic vascular disease. The aim of this study was to assess the association of apolipoprotein B/A1 ratio with insulin resistance and adiponectin in metabolic syndrome.

Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria applying the Asia-Pacific World Health Organization guidelines for WC. Total 1653 metabolic patients were enrolled in this study. BMI, WC, and serum concentration of apolipoprotein B, apolipoprotein A1, glucose, lipids (triglycerides, HDL cholesterol, and total cholesterol) and adiponectin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis model assessment (HOMA-IR). PWV was evaluated to assess arterial stiffness.

Apolipoprotein B/A1 ratio significantly correlated with total cholesterol (γ=0.349, P<0.01), TG (γ=0.191, P<0.01), LDL-C (γ=0.271, P<0.01), HDL-C (γ= -0.309, P<0.01), adiponectin (γ= -0.142, P<0.01), HOMA-IR (γ=0.048, P=0.049), insulin (γ=0.065, P=0.048), and peripheral PWV (γ=0.043, P=0.083). Multple regression analysis showed that Apolipoprotein B/A1 ratio was significantly associated with total cholesterol (β=0.360, P<0.01), TG (β=0.175, P<0.01), HDL-C (β= -0.325, P<0.01), HOMA-IR (β=0.057, P=0.04) and adiponectin (β= -0.160, P<0.01).

Adiponectin and insulin resistance are important independent factors associated with Apolipoprotein B/A1 ratio in metabolic syndrome.

 

Nothing to Disclose: JSP, CWA, KRK, SK, TWN, MKK, JH, HB, CK, SK