Environmental Stressors in Disease and Implications for Human Health

October 26 – 29, 2014 │ Boston Marriott Long Wharf Hotel, Boston, MA

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A printed program will be available onsite. Abstract books will not be available onsite. Download these materials to plan your meeting experience and view detailed information on your tablet, laptop, or other personal device.

PPTOX IV opens Sunday, October 26, 2014 at 6:00 PM. The program includes poster, plenary, and breakout sessions, as well as group discussion opportunities with international experts.

PPTOX IV hosts the world’s leading experts in endocrinology, toxicology, and environmental health to provide interdisciplinary discussions on the current landscape, future directions, and ongoing global implications of early life exposures in research, medicine, and regulation. Topics include endocrine disruptors, altered developmental programming, and susceptibility to endocrine disease later in life. The conference will:

  • Examine current evidence from animal and human studies investigating the developmental basis and mechanism of disease
  • Identify knowledge and training gaps and strategies to address them
  • Integrate basic, clinical, and translational sciences that address early life exposure science
  • Identify implications for public health and clinical medicine in building research agenda consensus for the next five years

Registration Opens at 4:00 PM, Sunday, October 26

Sunday, October 26, 2014 │ 6:00 – 8:00 PM

Session Time Session
Opening Session
  • PPTOX as a developmental origin of new science and new public health
    Philippe Grandjean, Univ of Southern Denmark/Harvard Sch of Pub Hlth
  • Developmental Origins of Health and Disease (DOHaD): A good start lasts a lifetime
    Linda S. Birnbaum, PhD, NIEHS/National Toxicology Program/NIH
  • Developmental origins of global health
    Emiko Todaka, PhD, WHO


Monday, October 27, 2014 │ 8:30 AM – 6:30 PM

Session Time Session

Plenary Session I: Developmental exposures and altered reproductive systems in men and women
Chairs: Sylvaine Cordier, PhD, DSc, Institut National de la Santé et de la Recherche Médicale (France) and Jorma Toppari, MD, PhD, University of Turku (Finland)
  • The androgenic action of stress during fetal development
    Shanna H. Swan, PhD, Icahn Sch of Med at Mount Sinai
  • Prenatal origin of polycystic ovarian syndrome
    Evanthia (Evi) Diamanti-Kandarakis, MD, PhD, Univ of Athens Medl Sch
  • Organochlorine pesticide exposure and development in boys through puberty
    Russ Hauser, MD, MPH, ScD, Harvard Sch of Pub Hlth
  • Sperm abnormalities in young men with lifetime exposure to dichlorodiphenyldichloro-ethylene (p,p’-DDE) and polychlorinated biphenyls
    Heather A Young, PhD, MPH, CHES, George Washington University School of Public Health and Health Services

10:00-10:30 Break
Breakout Session 1: Advances and insights from epigenetics
Chairs: Andrea Baccarelli, MD, MPH, PhD, Harvard Sch of Pub Hlth and Frederica P. Perera, DrPH, PhD, Columbia Univ Mailman Sch of Pub Hlth
  • Environmental estrogens activate non-genomic signaling to developmentally reprogram the epigenome
    Cheryl L. Walker, PhD, Texas A&M Hlth Sci Ctr
  • Validation of altered epigenetic marks in human blood cells
    Douglas A. Bell, PhD, NIEHS/NIH
  • Cell distribution prediction from DNA methylation data using a reference set derived from umbilical cord blood
    Julie Herbstman, PhD ScM, Columbia Mailman School of Public Health
  • Are differences in methylation in cord blood DNA associated with prenatal exposure to alcohol?
    Luisa Zuccolo, PhD, MSc, MRC Integrative Epidemiology Unit, University of Bristol
Breakout Session 2: Role of the placenta in developmental origins of health and disease
Chairs: Peter van den Hazel, MD, PhD, Intl Network for Children’s Hlth, Envir & Safety (The Netherlands) and Claudine Junien, PharmD, PhD, Institut National de Recherche Agronomique (France)
  • Placental epigenetic mechanisms
    Carmen J. Marsit, PhD, Dartmouth, Geisel Sch of Med
  • Sex-specific placental responses in fetal development
    Cheryl S. Rosenfeld, PhD, DVM, Univ of Missouri Coll of Vet Med
  • First trimester phthalate and phenol exposure is associated with miRNA alterations in the placenta
    Karin Michels, ScD, PhD, Harvard Medical School
  • Sexually dimorphic effect of gestational exposure to BPA on DNA methylation pattern in the rat placenta
    Julie Fudvoye, University of Liege
12:00-13:30 Lunch and Posters
Plenary Session II: Trans-generational inheritance
Chairs: Lisa H. Chadwick, PhD, NIEHS/NIH and Ruth Etzel, MD, PhD, University of Wisconsin-Milwaukee
  • Paternal dietary effects on offspring metabolism
    Oliver J. Rando, MD, PhD, Univ of Massachusetts Med Sch
  • Genomic imprinting, physiology and transgenerational inheritance
    Martha Susiarjo, PhD, Univ of Pennsylvania Perelman Sch of Med
  • Transgenerational effects on behavior resulting from BPA exposure
    Emilie F. Rissman, PhD, Univ of Virginia Sch of Med
  • Developmental exposure to 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) has implications for multi- and transgenerational effects on antiviral immunity
    Christina M Post, University of Rochester School of Medicine and Dentistry
15:00-15:30 Break
15:30-17:00 Breakout Session 3: Effects of developmental exposures on immune functions
Chairs: B. Paige Lawrence, PhD, Univ of Rochester Med Ctr Sch of Med & Dentistry and David H. Sherr, PhD, Boston Univ Sch of Pub Hlth
  • TCE-mediated epigenetic changes in T cell functions
    Kathleen Gilbert, PhD, Arkansas Children's Hosp Res Inst
  • Immune dysfunction in children with prenatal immunotoxicant exposures
    Berit B. Granum, PhD, Norwegian Inst of Pub Hlth
  • Early life environmental exposures and reduced response to infant tuberculosis vaccination
    Todd Jusko, PhD, University of Rochester School of Medicine and Dentistry
  • Fetal hematopoietic stem cells are the coalmine canaries portending adverse later-life immune outcomes
    Michael Laiosa, PhD, University of Wisconsin-Milwaukee
Breakout Session 4: Novel strategies for prospective birth cohorts
Chairs: Ludwine Casteleyn, MD , Univ of Leuven (Belgium) and Kimberly A. Gray, PhD, NIEHS/NIH
  • Birth cohort research as part of public health interventions
    Pál Weihe, MD, Faroese Hosp Sys
  • Strategies and results from the Japan Environment and Child Cohort
    Shoji F. Nakayama, MD, PhD, Natl Inst for Envir Studies (Japan)
  • Prenatal exposure to stress modifies the association between prenatal lead and infant neurodevelopment
    Marcela Tamayo y Ortiz, ID, ScM, ScD, Instituto Nacional de Salud Publica, Mexico
  • Individual and joint association of exposure to ambient PM2.5 and ozone and maternal smoking with preterm birth in the Boston Birth Cohort
    Rebecca Nachman, PhD, MPH, Johns Hopkins Bloomberg School of Public Health
Poster Reception

Tuesday, October 28, 2014 │ 7:30 AM – 6:30 PM

Session Time Session

Breakfast discussions - Concurrent discussion sessions moderated by expert faculty
  • Experimental approaches to DOHaD
    B. Paige Lawrence, PhD, Univ of Rochester Med Ctr Sch of Med & Dentistry
  • Consideration of developmental exposures in risk assessment
    Babasaheb (Bob) R. Sonawane, PhD, US EPA
  • Communicating with the public on developmental origins
    Ami R. Zota, ScD, MS, George Washington University and Elise Miller, Med, Collaborative on Health and the Environment
  • Clinical implications of developmental exposures
    Jean-PierreBourguignon, MD, PhD, Univ de Liège (Belgium)
  • Biomedical ethics
    Ruth Etzel, MD, PhD, Univ of Wisconsin-Milwaukee and Carl F. Cranor, PhD, MSL, University of California-Riverside
8:30-10:00 Plenary Session III: Developmental exposures in obesity etiologies
Chairs: Bruce Blumberg, PhD, University of California-Irvine and Sharon Munn, PhD, European Commission’s Joint Research Centre (Italy)
  • Pre- and postnatal exposure to persistent pollutants and obesity
    Damaskiní (Dania) Valvi, MD, MPH, Centre for Res in Envir Epidemiology (Spain)
  • Maternal exposure to BPA and obesity in the next generation
    Beverly S. Rubin, PhD, Tufts Univ Sch of Med
  • Integration of experimental and epidemiological approaches to developmental obesogenicity
    Juliette Legler, PhD, VU University Amsterdam
  • Prenatal phthalate exposures and body mass index among 4 to 7 year old children: A pooled analysis
    Jessie Buckley, MPH, University of North Carolina at Chapel Hill
10:00-10:30 Break
Breakout Session 5: Developmental exposures and diabetes pathogenesis
Chairs: Ana Navas-Acien, MD, Johns Hopkins Bloomberg Sch of Pub Hlth and Qi Sun, MD, ScD, MMS, Harvard Sch of Pub Hlth
  • Abnormalities of glucose metabolism in children exposed to diabetogenic environmental chemicals
    Tina K. Jensen, MD, Univ of Southern Denmark
  • Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic outcomes in adult offspring
    Jessica L. Bolton, Duke Univ
  • Maternal smoking during pregnancy and offspring type 1 diabetes mellitus risk – accounting for HLA haplotype
    Kristina Mattsson, MSc, Division of Occupational and Environmental Medicine
  • Developmental exposure to the endocrine disruptor tolylfluanid alters energy metabolism in adult mice
    Rober M. Sargis, MD, PhD, University of Chicago
Breakout Session 6: Challenges in improving exposure assessments
Chairs: Eun-Hee Ha, MD, PhD, Ewha Womans Univ Sch of Med (Korea) and William Suk, PhD, MPH, NIEHS/NIH
  • Environment-wide association studies of developmental exposures
    Chirag J. Patel, PhD, Harvard Medical School
  • Identifying Cumulative Exposures to Chemicals in Pregnant Women – A Non-Targeted Exposome Approach
    Tracey J. Woodruff, PhD, MPH, Univ of California-San Francisco
  • Urinary concentrations of polycyclic aromatic hydrocarbons in Israeli adults: Demographic and life-style predictors
    Hagai Levine, MD, MPH, Braun School of Public Health and Community Medicine, Hebrew University-Hadassah
  • Derivation of cumulative toxicity indicators for indoor semi-volatile organic compounds: the case of reprotoxic and neurotoxic mixtures
    Kevin Fournier, Ecole des hautes études en santé publique
12:00-13:30 Lunch and Posters
Plenary Session IV: Developmental exposures and neurobehavioral disorders
Chairs: David C. Bellinger, PhD, Harvard Sch of Pub Hlth and Peter D. Sly, MBBS, MD, FRACP, DSc, FThorSoc, The Univ of Queensland
  • Novel approaches to assessing cognitive function in early infancy
    Susan L. Schantz, PhD, Univ of Illinois at Urbana-Champaign
  • Air pollution and developmental neurotoxicity
    Jordi Sunyer, MD, PhD, Centre for Res in Envir Epidemiology (Spain)
  • Early-life lead exposure in vulnerability to Alzheimer’s-like neurodegeneration
    Nasser H. Zawia, PhD, Univ of Rhode Island
  • Prenatal Synthetic Glucocorticoids and Multigenerational Paternal Programming of Offspring Behaviour and HPA Function
    Vasilis G. Moisiadis, BSc, University of Toronto
15:00-15:30 Break
15:30-17:00 Breakout Session 7: Emerging concepts, new endpoints and methodologies
Chairs: Margaret R. Karagas, PhD, Dartmouth, Geisel Sch of Med and Toshihiro Kawamoto, MD, PhD, Univ of Occupational and Envir Hlth(Japan)
  • Developmental stress and children’s telomere length
    Daniel A. Notterman, MD, Princeton Univ/Pennsylvania State Univ
  • Identification of epigenetic patterns in birth cohorts
    Allan C. Just, PhD, Harvard School of Public Health
  • Arsenic exposure, breast feeding and infant microbiome composition in a US birth cohort
    Anne G. Hoen, PhD, Geisel School of Medicine at Dartmouth
  • Potential impact of pesticide exposures during pregnancy on the newborn’s metabolome
    Nathalie Bonvallot, INSERM IRSET
Breakout Session 8: Early life antecedents of cancer
Chairs: Robert Barouki, MD, PhD, Univ Paris Descartes Centre Univ des Saints Pères (France) and David Christiani, MD, MPH, MS, Harvard Sch of Pub Hlth
  • Stem cells as targets that lead to increased cancer susceptibility
    Gail S. Prins, PhD, Univ of Illinois-Chicago
  • Progesterone and overlooked endocrine pathways in breast cancer pathogenesis
    Cathrin Brisken, MD, PhD, Ecole Polytechnique Fed de Lausanne, Swiss Inst for Exp Cancer Res (ISREC)
  • Prenatal and lifespan exposure enhances the sensitivity of carcinogenicity bioassays: The cases of artificial sweeteners aspartame and sucralose
    Michela Padovani, Cesare Maltoni Cancer Research Center, Ramazzini Institute
  • Prenatal exposure of mice to the human liver carcinogen Aflatoxin B1 reveals a critical window of susceptibility to genetic change
    Supawadee Chawanthayatham, PhD, Massachusetts Institute of Technology
Poster Reception

Wednesday, October 29, 2014 │ 8:30 AM – 5:30 PM

Session Time Session
8:30-10:00 Plenary Session V: Early-life stresses and late-life disease
Chairs: Emily Oken, MD, MPH, Harvard Med Sch and Alvaro Puga, PhD, Univ of Cincinnati
  • Transgenerational effects on cardiac development in zebra fish
    Warren Heideman, PhD, Univ of Wisconsin-Madison
  • Developmental origins of cardiovascular disease
    Johan G. Eriksson, MD, DMSc, Univ of Helsinki
  • Early-life stresses and schizophrenia risk
    Ezra S. Susser, MD, DrPH, MPH, Columbia Univ Mailman Sch of Pub Hlth
  • Prenatal and childhood adversity and inflammation in adulthood
    Natalie Slopen, University of Maryland College Park
10:00-10:30 Break
10:30-12:00 Plenary Session VI: Developing a global definition of DOHaD
Chair: John M. Balbus, MD, MPH,NIEHS/NIH and Elizabet Paunovic, MD, World Health Organization
  • Role of environmental chemical exposures
    Linda S. Birnbaum, PhD, DABT, ATS NIEHS/NIH
  • Role of nutrition
    Matthew W. Gillman, MD, Harvard Med Sch
  • Role of stress
    Deborah A. Cory-Slechta, PhD, Univ of Rochester Med Ctr
  • Integration of "environment" into DOHaD definition
    Jerrold J. Heindel, PhD, NIEHS/NIH
12:00-13:30 Lunch
Plenary Session VII: Translating science to improve public health
Chairs: Philip J. Landrigan, MD, MSc, FAAP, Icahn School of Medicine, Mount Sinai and Gwen W. Collman, PhD, National Institute of Environmental Health Sciences/NIH (Canada)
  • The precautionary principle in action
    Hans Bruyninckx, PhD, European Envir Agency
  • The clinician's role in protecting early development
    Jeanne A. Conry, MD, PhD, The Permanente Medical Group
  • Translating ecological effects to protection of human health
    Louis J. Guillette Jr., PhD, Med Univ of South Carolina
  • Incorporation of principles from research on early life exposure and effects into analysis for environmental health policies: case studies from the US
    Amy D. Kyle, PhD, MPH, University of California-Berkeley
15:00-15:30 Break
Plenary Session VIII: Developing a global DOHaD network
Chairs: Claudia L. Thompson, PhD, NIEHS/NIH and Emiko Todaka, PhD, WHO
  • DOHaD Society efforts to build a global DOHaD network
    Mark A. Hanson, PhD, Univ of Southampton
  • Creating a DoHAD global network: Using other networks as a model
    William Suk, PhD, MPH, NIEHS/NIH
  • Integration of DOHaD concepts in WHO global health efforts
    Marie-Noel Bruné Drisse, MSc, World Health Organization
  • Comments on developing a DOHaD network and panel discussion
    Philippe Grandjean, MD, DMSc, University of Southern Denmark/Harvard School of Public Health, Peter D. Sly, MBBS, MD, FRACP, DSc, FThorSoc, The University of Queensland, and Argelia Castaño, PhD, Instituto de Salud Carlos III
Closing remarks
  • The PPTOX IV conference statement
    Philippe Grandjean, MD, DMSc, Univ of Southern Denmark/Harvard Sch of Pub Hlth
  • Future directions and meeting summary
    Jerrold J. Heindel, PhD, NIEHS/NIH
  • The future of PPTOX