Stay up to date with new guidelines on managing primary aldosteronism
Apply the new practice guideline on primary aldosteronism, which calls primary aldosteronism a major public health challenge. Research shows that an excessive level of aldosterone, far from being a rare and benign condition, is a common, damaging, and treatable cause of hypertension.
ENDO Session | No credit available
William F Young, Jr., MD, MSc
Review email consults in a computer-based CPC to learn practical approaches to diagnosing and treating hyperaldosteronism.
Management of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline
ENDO Session | No credit available
Stefan Bornstein, MD, PhD; Wiebke Arlt, MD, DSc; Constantine A. Stratakis, MD; Deborah P. Merke, MS, MD; Eystein Sverre Husebye, MD, PhD; David J Torpy, MBBS, PhD; Andrew C. Don-Wauchope, MD; and Paul M. Stewart, MD
Hear the recommendations and controversies directly from the guideline committee with case examples and rationales for the newest guideline.
Endocrine Facts & Figures: Adrenal
Research Resource | No credit available
Advisory Panel Chair: Robert A. Vigersky, MD
Updated epidemiological data and in-depth discussion on adrenal insufficiency and Cushing syndrome with current citations and expert insights.
A Probabilistic Model for Cushing's Syndrome Screening in At-Risk Populations: A Prospective Multicenter Study JCEM | August 4, 2016 Antonio León-Justel, Ainara Madrazo-Atutxa, Ana I. Alvarez-Rios, Rocio Infantes-Fontán, Juan A. Garcia-Arnés, Juan A. Lillo-Muñoz, Anna Aulinas, Eulàlia Urgell-Rull, Mauro Boronat, Ana Sánchez-de-Abajo, Carmen Fajardo-Montañana, Mario Ortuño-Alonso, Isabel Salinas-Vert, Maria L. Granada, David A. Cano and Alfonso Leal-Cerro
Cushing's syndrome (CS) is challenging to diagnose. Increased prevalence of CS in specific patient populations has been reported, but routine screening for CS remains questionable…
Familial Adrenocortical Carcinoma in Association with Lynch Syndrome JCEM | May 04, 2016 Benjamin G. Challis, Narayanan Kandasamy, Andrew S. Powlson, Olympia Koulouri, Anand Kumar Annamalai, Lisa Happerfield, Alison J. Marker, Mark J. Arends, Serena Nik-Zainal, and Mark Gurnell
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Although the majority of childhood ACC arises in the context of inherited cancer…
Rare Causes of Primary Adrenal Insufficiency: Genetic and Clinical Characterization of a Large Nationwide Cohort JCEM | November 2, 2015 Tulay Guran, Federica Buonocore, Nurcin Saka, Mehmet Nuri Ozbek, Zehra Aycan, Abdullah Bereket, Firdevs Bas, Sukran Darcan, Aysun Bideci, Ayla Guven, Korcan Demir, Aysehan Akinci, Muammer Buyukinan, Banu Kucukemre Aydin, Serap Turan, Sebahat Yilmaz Agladioglu, Zeynep Atay, Zehra Yavas Abali, Omer Tarim, Gonul Catli, Bilgin Yuksel, Teoman Akcay, Metin Yildiz, Samim Ozen, Esra Doger, Huseyin Demirbilek, Ahmet Ucar, Emregul Isik, Bayram Ozhan, Semih Bolu, Ilker Tolga Ozgen, Jenifer P. Suntharalingham and John C. Achermann
Primary adrenal insufficiency (PAI) is a life-threatening condition that is often due to monogenic causes in children. Although congenital adrenal hyperplasia occurs commonly, several other…
The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment JCEM | March 2, 2016 John W. Funder, Robert M. Carey, Franco Mantero, M. Hassan Murad, Martin Reincke, Hirotaka Shibata, Michael Stowasser, and William F. Young Jr.
For high-risk groups of hypertensive patients and those with hypokalemia, we recommend case detection of primary aldosteronism by determining the aldosterone-renin ratio …
Diagnosis and Treatment of Primary Adrenal Insufficiency JCEM | February 01, 2016
Stefan R. Bornsteinchair, Bruno Allolio, Wiebke Arlt, Andreas Barthel, Andrew Don-Wauchope, Gary D. Hammer, Eystein S. Husebye, Deborah P. Merke, M. Hassan Murad, Constantine A. Stratakis, and David J. Torpy
We recommend diagnostic tests for the exclusion of primary adrenal insufficiency in all patients with indicative clinical symptoms or signs. In particular, we suggest a low diagnostic…
Treatment of Cushing's Syndrome JCEM | July 29, 2015 Lynnette K. Nieman, Beverly M. K. Biller, James W. Findling, M. Hassan Murad, John Newell-Price, Martin O. Savage, and Antoine Tabarin
Treatment of Cushing's syndrome is essential to reduce mortality and associated comorbidities. Effective treatment includes the normalization of cortisol levels or action. It also includes…
Diagnosis and Treatment of Pheochromocytoma and Paraganglioma JCEM | June 3, 2014 Jacques W. M. Lenders, Quan-Yang Duh, Graeme Eisenhofer, Anne-Paule Gimenez-Roqueplo, Stefan K. G. Grebe, Mohammad Hassan Murad, Mitsuhide Naruse, Karel Pacak, and William F. Young Jr
The Task Force recommends that initial biochemical testing for PPGLs should include measurements of plasma free or urinary fractionated metanephrines. Consideration should be given to preanalytical factors…
Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency JCEM | April 30, 2011 Phyllis W. Speiser, Ricardo Azziz, Laurence S. Baskin, Lucia Ghizzoni, Terry W. Hensle, Deborah P. Merke, Heino F. L. Meyer-Bahlburg, Walter L. Miller, Victor M. Montori, Sharon E. Oberfield, Martin Ritzen, and Perrin C. White
We recommend universal newborn screening for severe steroid 21-hydroxylase deficiency followed by confirmatory tests. We recommend that prenatal treatment of CAH continue to be regarded as…
The Diagnosis of Cushing's Syndrome JCEM | January 14, 2009 Lynnette K. Nieman, Beverly M. K. Biller, James W. Findling, John Newell-Price, Martin O. Savage, Paul M. Stewart, and Victor M. Montori
After excluding exogenous glucocorticoid use, we recommend testing for Cushing's syndrome in patients with multiple and progressive features compatible with the syndrome, particularly those with…