Adrenal Health and Disease

AdrenalStay up to date with new guidelines on managing primary aldosteronism

Apply the new practice guideline on adrenal insufficiency, which calls primary aldosteronism a major public health challenge. Research shows that an excessive level of aldosterone, far from being a rare and benign condition.

Stressed Out: New Treatment Guidelines for Primary Aldosteronism
October 2016 | A new Endocrine Society Clinical Practice Guideline calls primary aldosteronism a major public health challenge. Research shows that an excessive level of aldosterone, far from…

John W. Funder Awarded Fondation IPSEN Endocrine Regulations Prize
September 2016 | Endocrine Society member John W. Funder, MD, PhD, of Prince Henry’s Institute in Victoria, Australia, today was awarded the Fondation PSEN Endocrine Regulations Prize for…

Primary Hyperaldosteronism
ENDO Session | No credit available
William F Young, Jr., MD, MSc
Review email consults in a computer-based CPC to learn practical approaches to diagnosing and treating hyperaldosteronism.

Clinical Management of Adrenocortical Carcinoma
ENDO Session | No credit available
Martin Fassnacht, MD
Review the options, as well as the pros and cons for each step in surgical and medical management of ACC.

Management of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline
ENDO Session | No credit available
Stefan Bornstein, MD, PhD; Wiebke Arlt, MD, DSc; Constantine A. Stratakis, MD; Deborah P. Merke, MS, MD; Eystein Sverre Husebye, MD, PhD; David J Torpy, MBBS, PhD; Andrew C. Don-Wauchope, MD; and Paul M. Stewart, MD
Hear the recommendations and controversies directly from the guideline committee with case examples and rationales for the newest guideline.

Endocrine Facts & Figures: Adrenal
Research Resource | No credit available
Advisory Panel Chair: Robert A. Vigersky, MD
Updated epidemiological data and in-depth discussion on adrenal insufficiency and Cushing syndrome with current citations and expert insights.

A SDHC Founder Mutation Causes Paragangliomas (PGLs) in the French Canadians: New Insights on the SDHC-Related PGL
JCEM | October 4, 2016
Isabelle Bourdeau, Solange Grunenwald, Nelly Burnichon, Emmanuel Khalifa, Nadine Dumas, Marie-Claire Binet, Serge Nolet and Anne-Paule Gimenez-Roqueplo
More than 40% of patients with paragangliomas (PGLs) harbor a germline mutation of the known PGL susceptibility genes, mainly in the SDHB or SDHD genes…

A Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans
JCEM | September 28, 2016
Agnieszka Pazderska, Bergithe E. Oftedal, Catherine M. Napier, Holly F. Ainsworth, Eystein S. Husebye, Heather J. Cordell, Simon H. S. Pearce and Anna L. Mitchell
Autoimmune Addison's disease (AAD) is a rare but highly heritable condition. The BACH2 protein plays a crucial role in T lymphocyte maturation, and allelic variation…

Exploring Inpatient Hospitalizations and Morbidity in Patients With Adrenal Insufficiency
JCEM | September 13, 2016
Paul M. Stewart, Beverly M. K. Biller, Claudio Marelli, Candace Gunnarsson, Michael P. Ryan and Gudmundur Johannsson
Patients with adrenal insufficiency (AI) (primary AI [PAI], secondary AI due to a pituitary disorder [PIT] and congenital adrenal hyperplasia [CAH]) have reduced life expectancy…

A Probabilistic Model for Cushing's Syndrome Screening in At-Risk Populations: A Prospective Multicenter Study
JCEM | August 4, 2016
Antonio León-Justel, Ainara Madrazo-Atutxa, Ana I. Alvarez-Rios, Rocio Infantes-Fontán, Juan A. Garcia-Arnés, Juan A. Lillo-Muñoz, Anna Aulinas, Eulàlia Urgell-Rull, Mauro Boronat, Ana Sánchez-de-Abajo, Carmen Fajardo-Montañana, Mario Ortuño-Alonso, Isabel Salinas-Vert, Maria L. Granada, David A. Cano and Alfonso Leal-Cerro
Cushing's syndrome (CS) is challenging to diagnose. Increased prevalence of CS in specific patient populations has been reported, but routine screening for CS remains questionable…

Study Heterogeneity and Estimation of Prevalence of Primary Aldosteronism: A Systematic Review and Meta-Regression Analysis
JCEM | May 12, 2016
Sabine C. Käyser, Tanja Dekkers, Hans J. Groenewoud, Gert Jan van der Wilt, J. Carel Bakx, Mark C. van der Wel, Ad R. Hermus, Jacques W. Lenders and Jaap Deinum
For health care planning and allocation of resources, realistic estimation of the prevalence of primary aldosteronism is necessary. Reported prevalences of primary aldosteronism are highly…

Familial Adrenocortical Carcinoma in Association with Lynch Syndrome
JCEM | May 04, 2016
Benjamin G. Challis, Narayanan Kandasamy, Andrew S. Powlson, Olympia Koulouri, Anand Kumar Annamalai, Lisa Happerfield, Alison J. Marker, Mark J. Arends, Serena Nik-Zainal, and Mark Gurnell
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Although the majority of childhood ACC arises in the context of inherited cancer…

Classics in Cardiovascular Endocrinology: Aldosterone Action Beyond Electrolytes
Endocrinology | February 1, 2016
Richard J. Auchus
In 1856, Charles-Edouard Brown-Sequard demonstrated that adrenalectomy was fatal in laboratory animals. He interpreted these experiments as evidence that the adrenals produced substances that are…

Rare Causes of Primary Adrenal Insufficiency: Genetic and Clinical Characterization of a Large Nationwide Cohort
JCEM | November 2, 2015
Tulay Guran, Federica Buonocore, Nurcin Saka, Mehmet Nuri Ozbek, Zehra Aycan, Abdullah Bereket, Firdevs Bas, Sukran Darcan, Aysun Bideci, Ayla Guven, Korcan Demir, Aysehan Akinci, Muammer Buyukinan, Banu Kucukemre Aydin, Serap Turan, Sebahat Yilmaz Agladioglu, Zeynep Atay, Zehra Yavas Abali, Omer Tarim, Gonul Catli, Bilgin Yuksel, Teoman Akcay, Metin Yildiz, Samim Ozen, Esra Doger, Huseyin Demirbilek, Ahmet Ucar, Emregul Isik, Bayram Ozhan, Semih Bolu, Ilker Tolga Ozgen, Jenifer P. Suntharalingham and John C. Achermann
Primary adrenal insufficiency (PAI) is a life-threatening condition that is often due to monogenic causes in children. Although congenital adrenal hyperplasia occurs commonly, several other…

The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment
JCEM | March 2, 2016
John W. Funder, Robert M. Carey, Franco Mantero, M. Hassan Murad, Martin Reincke, Hirotaka Shibata, Michael Stowasser, and William F. Young Jr.
We achieved consensus by collecting the best available evidence and conducting one group meeting, several conference calls, and multiple e-mail communications. With the help of…

Treatment of Cushing's Syndrome
JCEM | July 29, 2015
Lynnette K. Nieman, Beverly M. K. Biller, James W. Findling, M. Hassan Murad, John Newell-Price, Martin O. Savage, and Antoine Tabarin
Treatment of Cushing's syndrome is essential to reduce mortality and associated comorbidities. Effective treatment includes the normalization of cortisol levels or action. It also includes…

Diagnosis and Treatment of Pheochromocytoma and Paraganglioma
JCEM | June 3, 2014
Jacques W. M. Lenders, Quan-Yang Duh, Graeme Eisenhofer, Anne-Paule Gimenez-Roqueplo, Stefan K. G. Grebe, Mohammad Hassan Murad, Mitsuhide Naruse, Karel Pacak, and William F. Young Jr
The Task Force recommends that initial biochemical testing for PPGLs should include measurements of plasma free or urinary fractionated metanephrines. Consideration should be given to preanalytical factors…

Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency
JCEM | April 30, 2011
Phyllis W. Speiser, Ricardo Azziz, Laurence S. Baskin, Lucia Ghizzoni, Terry W. Hensle, Deborah P. Merke, Heino F. L. Meyer-Bahlburg, Walter L. Miller, Victor M. Montori, Sharon E. Oberfield, Martin Ritzen, and Perrin C. White
We recommend universal newborn screening for severe steroid 21-hydroxylase deficiency followed by confirmatory tests. We recommend that prenatal treatment of CAH continue to be regarded as…

The Diagnosis of Cushing's Syndrome
JCEM | January 14, 2009
Lynnette K. Nieman, Beverly M. K. Biller, James W. Findling, John Newell-Price, Martin O. Savage, Paul M. Stewart, and Victor M. Montori
After excluding exogenous glucocorticoid use, we recommend testing for Cushing's syndrome in patients with multiple and progressive features compatible with the syndrome, particularly those with…

42nd International Aldosterone Conference
Dates: March 30 - 31, 2017
Location: Orlando, Florida, United States
Sponsor: ICCBH

5th International Symposium on Phaeochromocytoma and Paraganglioma
Dates: August 30 – September 2, 2017
Location: Wentworth, Australia
Sponsor: ASN Events

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