Male reproAdvancing Research and Ensuring Reproductive Health

Explore recent research and guidelines on factors impacting fertility, reproductive health, and aging in men including testosterone studies, sexual development, and osteoporosis.

Hormones Are Behind Hernias of the Groin in Elderly Men, Study Suggests
April 3, 2017 | Researchers have identified an apparent cause of inguinal hernia, or groin hernia, in older men: altered sex hormone levels that weaken and scar muscle…

Higher Anabolic Hormone Levels Predict Lower Risk of Worsening Frailty in Men
April 3, 2017 | A new study suggests that middle-age and elderly men are less likely to develop worsening frailty if they have high levels of certain anabolic hormones, which are muscle- and bone-building hormones. The study…

Estetrol (E4) Shows Promise as a Safe Effective Drug for Use in Advanced Prostate Cancer
April 3, 2017 | The natural fetal estrogen estetrol, also called E4, is being tested as a new drug that may help treat advanced prostate cancer, according to an ongoing industry-sponsored study&hellip

Many Transgender Individuals Consider Their Fertility Important, Survey Shows
April 2, 2017 | Nearly one-fourth of transgender individuals in Toronto, Canada, regard their own fertility as important, but most lack knowledge regarding and access to reproductive options…

New Molecules May Offer Treatment Option for Some Aggressive Prostate Cancers
April 1, 2017 | Novel molecules called selective androgen receptor degraders (SARDs) may offer the next generation of treatment options for advanced prostate cancer, a new industry-sponsored study&hellip

Landmark Study Defines Normal Ranges for Testosterone Levels
January 10, 2017 | New defined reference range can help limit misdiagnoses and unnecessary treatments. A large study of more than 9,000 men has established harmonized reference ranges for total testosterone in men that when applied to assays that have been appropriately calibrated will effectively enable…

Survey: Endocrinologists Want Training in Transgender Care
January 10, 2017 | Four out of five physicians who specialize in treating hormone health conditions have never received formal training on care for transgender individuals, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism

Tri-Point: The Genetics and Epigenetics of Puberty
January 2017 | In 2005, the editors of Science, celebrating the journal’s 125th anniversary, posed 125 unanswered questions that it predicted would fuel active research…

Male Birth Control Shots Prevent Pregnancy
October 27, 2016 | Researchers call for further study to reduce risk of depression, side effects. Men can take birth control shots to prevent pregnancy in their female partners…

Men Get Osteoporosis, Too | New York Times
October 3, 2016 | Listen, men, this is important, important to your current and future health and perhaps your life. Osteoporosis is not just a woman’s disease. Men get it too…

Explore highlights of current education across the Endocrine Society.


Gender-Affirming Endocrine Care of Transgender and Gender Non-Binary People
ENDO Session | No credit available
Guy G. T'Sjoen, MD, PhD
Are you prepared to deliver essential endocrine care to this underserved and often misunderstood patient population?

Partnership for the Accurate Testing of Hormones: Testosterone
Practice Resource | No credit available
Use PATH as your resource to know which assay to use and what the results mean when measuring testosterone.

What have we learned from randomized trials about the efficacy of testosterone therapy?
ENDO Session | No credit available
Chair: Shalender Bhasin, MD
Stay up to date on the outcomes of recent trials on testosterone therapy that include TTrials, TEAAM, and Lilly Testosterone Solution trials.

Men’s Health Digital Toolkit
Patient Resource | No credit available
Reviewer: Bradley D. Anawalt, MD
Interactive and downloadable resources and information for patients with questions related to women’s health including erectile dysfunction, fertility, and testosterone.

Explore highlights of current publications across the Endocrine Society journals. Visit academic.oup.com/endocrinesociety for more.


Genetic Variation of Follicle-Stimulating Hormone Action is Associated with Age at Testicular Growth in Boys
JCEM | February 27, 2017
Alexander S. Busch, Casper P. Hagen, Katharina M. Main, Anita Pereira, Camila Corvalan, Kristian Almstrup, Veronica Mericq, and Anders Juul
Context: Although genetic factors play a pivotal role in male pubertal timing, genome-wide association…

Harmonized Reference Ranges for Circulating Testosterone Levels in Men of Four Cohort Studies in the United States and Europe
JCEM | January 10, 2017
Thomas G. Travison, Hubert W. Vesper, Eric Orwoll, Frederick Wu, Jean Marc Kaufman, Ying Wang, Bruno Lapauw, Tom Fiers, Alvin M. Matsumoto, and Shalender Bhasin
The reference range refers to the distribution of the circulating concentrations of a hormone or an analyte in a specific population. Rigorously derived reference ranges are essential for distinguishing…

Efficacy and Safety of an Injectable Combination Hormonal Contraceptive for Men
JCEM | October 27, 2016
Robert I. McLachlan, M. Cristina Meriggiola, Man Mohan Misro, Gabriela Noe, Frederick C. W. Wu, Mario Philip R. Festin, Ndema A. Habib, Kirsten M. Vogelsong, Marianne M. Callahan, Kim A. Linton, and Doug S. Colvard
Context: The development of a safe and effective reversible method of male contraception is still an unmet need. Objective: Evaluation of suppression of spermatogenesis and…

Effects of Testosterone Supplementation for 3 Years on Muscle Performance and Physical Function in Older Men
JCEM | October 18, 2016
Thomas W. Storer, Shehzad Basaria, Tinna Traustadottir, S. Mitchell Harman, Karol Pencina, Zhuoying Li, Thomas G. Travison, Renee Miciek, Panayiotis Tsitouras, Kathleen Hally, Grace Huang, and Shalender Bhasin
Testosterone levels decline with advancing age (1, 2) and have been associated with the age-related changes in lean body…

Cross-Sex Hormone Treatment and Psychobiological Changes in Transsexual Persons: Two-Year Follow-Up Data
JCEM | October 4, 2016
Alessandra D. Fisher, Giovanni Castellini, Jiska Ristori, Helen Casale, Emanuele Cassioli, Carolina Sensi, Egidia Fanni, Ann Maria Letizia Amato, Eva Bettini, Maddalena Mosconi, Davide Dèttore, Valdo Ricca, and Mario Maggi
Gender dysphoria (GD) is characterized by a marked incongruence between one’s experienced/expressed gender and the assigned one, associated with clinically significant distress or impairment in social, occupational, or other important areas of functioning (1). Because GD can occur with different levels of intensity, a flexible…

Characteristics of Men Who Report Persistent Sexual Symptoms after Finasteride Use for Hair Loss
JCEM | September 23, 2016
Shehzad Basaria, Ravi Jasuja, Grace Huang, Whitney Wharton, Hong Pan, Karol Pencina, Zhuoying Li, Thomas G. Travison, Jag Bhawan, Renaud Gonthier, Fernand Labrie, Alain Y. Dury, Carlo Serra, Allen Papazian, Michael O'Leary, Sami Amr, Thomas W. Storer, Emily Stern, and Shalender Bhasin
Context: Some men who use finasteride for hair loss report persistent sexual and other symptoms after discontinuing finasteride therapy. Objective: To determine whether these persistent…

Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice
Endocrinology | July 1, 2016
Manjunatha K. Nanjappa, Rex A. Hess, Theresa I. Medrano, Seth H. Locker, Ellis R. Levin, and Paul S. Cooke
Estrogen receptor 1 (ESR1) mediates major reproductive functions of 17β-estradiol (E2). Male Esr1 knockout (Esr1KO) mice are infertile due to efferent ductule and epididymal…

Testosterone Treatment and Sexual Function in Older Men with Low Testosterone Levels
JCEM | June 29, 2016
Glenn R. Cunningham, Alisa J. Stephens-Shields, Raymond C. Rosen, Christina Wang, Shalender Bhasin, Alvin M. Matsumoto, J. Kellogg Parsons, Thomas M. Gill, Mark E. Molitch, John T. Farrar, David Cella, Elizabeth Barrett-Connor, Jane A. Cauley, Denise Cifelli, Jill P. Crandall, Kristine E. Ensrud, Laura Gallagher, Bret Zeldow, Cora E. Lewis, Marco Pahor, Ronald S. Swerdloff, Xiaoling Hou, Stephen Anton, Shehzad Basaria, Susan J. Diem, Vafa Tabatabaie, Susan S. Ellenberg, and Peter J. Snyder
Context: The Testosterone Trials are a coordinated set of seven trials to determine the efficacy of T in symptomatic men ≥65 years old with unequivocally low T levels…

Effects of Testosterone and Estradiol Deficiency on Vasomotor Symptoms in Hypogonadal Men
JCEM | June 14, 2016
Alexander P. Taylor, Hang Lee, Matthew L. Webb, Hadine Joffe, and Joel S. Finkelstein
Context: The hormonal basis of vasomotor symptoms (VMS) in hypogonadal men is incompletely understood. Objective: To determine the contributions of testosterone and estradiol deficiency to…

Low Testosterone: A Risk Marker Rather Than a Risk Factor for Type 2 Diabetes
JCEM | June 10, 2016
Stine A. Holmboe, Tina K. Jensen, Allan Linneberg, Thomas Scheike, Betina H. Thuesen, Niels E. Skakkebaek, Anders Juul, and Anna-Maria Andersson
Context: Low serum T levels have been associated with type 2 diabetes (T2D) and cardiovascular disease. However, it is unresolved whether low T is a risk factor…

For a complete list of Endocrine Society guidelines, visit endocrine.org/guidelines.


Osteoporosis in Men
JCEM | July 2, 2013
Nelson B. Watts, Robert A. Adler, John P. Bilezikian, Matthew T. Drake, Richard Eastell, Eric S. Orwoll, and Joel S. Finkelstein
Osteoporosis in men causes significant morbidity and mortality. We recommend testing higher risk men [aged ≥70 and men aged 50–69 who have risk factors…

Endocrine Treatment of Transsexual Persons
JCEM | April 30, 2011
Wylie C. Hembree, Peggy Cohen-Kettenis, Henriette A. Delemarre-van de Waal, Louis J. Gooren, Walter J. Meyer, III, Norman P. Spack, Vin Tangpricha, and Victor M. Montori
Transsexual persons seeking to develop the physical characteristics of the desired gender require a safe, effective hormone regimen that will 1) suppress endogenous hormone secretion…

Testosterone Therapy in Men with Androgen Deficiency Syndromes
JCEM | April 30, 2011
Shalender Bhasin, Glenn R. Cunningham, Frances J. Hayes, Alvin M. Matsumoto, Peter J. Snyder, Ronald S. Swerdloff, and Victor M. Montori
We recommend making a diagnosis of androgen deficiency only in men with consistent symptoms and signs and unequivocally low serum testosterone levels. We suggest the measurement…

For additional meetings, visit the Endocrine Society’s Worldwide Endocrinology Calendar at endocrine.org/calendar.


Society for the Study of Reproduction 2017 Annual Meeting
Dates: July 13 - 16, 2017
Location: Washington, DC, United States
Sponsor: Society for the Study of Reproduction

Clinical Endocrinology Update & Endocrine Board Review
Dates: September 23–27, 2017
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
Whether you need the latest clinical information or you’re preparing to certify or recertify for the boards, Clinical Endocrinology Update (CEU) and Endocrine Board Review (EBR) have you covered.

ENDO Bridge
Dates: October 19–22, 2017
Location: Antalya, Turkey
Sponsor: Endocrine Society, the European Society of Endocrinology, and The Society of Endocrinology and Metabolism of Turkey
EndoBridge will provide a comprehensive update in the field of endocrinology for the clinical endocrinologist. The official language of the meeting is English, but simultaneous translation will be available in Russian, Arabic, and Turkish

2017 American Society for Reproductive Medicine Congress and Expo
Dates: October 28 - November 1, 2017
Location: Washington, DC, United States
Sponsor: American Society for Reproductive Medicine

ENDO 2018
Dates: March 17–20, 2018
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
ENDO is the world’s largest event for presenting and obtaining the latest in endocrine science and medicine with an extensive program covering a broad array of topics, various networking opportunities, poster sessions, updates on new products and technologies at the ENDOExpo, and more.

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