BoneDiscover Updates in New and Emerging Therapies

Sessions, journal articles, and point of care tools highlight the molecular discoveries and evolving treatment options for rare metabolic bone diseases and osteoporosis in patients of all ages.

Disrupted Stress Hormone Signals in Bone Cells Protect from Diet-Induced Obesity
April 4, 2017 | A high-calorie diet, even without a high amount of fat, causes bone loss, and both high-calorie and high-fat diets induce excessive fat gain and insulin resistance…

New Measurement Technique Lowers Estimated Vitamin D Recommended Daily Allowance
April 2, 2017 | After re-measurement of vitamin D by improved technology, the Recommended Dietary Allowance (RDA) for vitamin D intake drops from 800 to 400…

Prolonged Sleep Disturbance Can Lead to Lower Bone Formation
April 1, 2017 | Insufficient sleep, a common problem that has been linked to chronic disease risk, might also be an unrecognized risk factor for bone loss. Results of a new study…

Menopausal Hormone Therapy Improves Bone Health
November 17, 2016 | Study reveals bone density, structure benefits persist after treatment ends. Women who undergo hormone therapy for menopausal symptoms such as hot flashes can not only increase…

Customized Vitamin D Supplements May Benefit Pregnant Women
October 27, 2016 | Doses can be tailored to compensate for individual risk factors, protect bone health. Individualized supplement doses help protect pregnant women from vitamin D deficiency, according…

Chemical Exposure Linked to Lower Vitamin D Levels
September 20, 2016 | Endocrine-disrupting chemicals may alter active form of vitamin in body. Exposure to bisphenol A (BPA) and other endocrine-disrupting chemicals (EDCs) may reduce levels of vitamin D…

Explore highlights of current education across the Endocrine Society.


Case-Based Update on Hypoparathyroidism
CEU Satellite Symposium | 2.0 AMA PRA Category 1 Credits™
Chair: Steven T. Harris, MD
Faculty: Susan M. Ott, MD; Lynn A. Kohlmeier, MD; and Nelson B. Watts, MD
Weigh the traditional and contemporary treatment options with discussions on diagnostic and etiology.

Hypophosphatasia: New Options in the Management of Alkaline Phosphatase Deficiency
ENDO Satellite Symposium | 2.0 AMA PRA Category 1 Credits™ and ABIM MOC Part 2 points
Chair: Jill H. Simmons, MD
Faculty: Nancy S. Dunbar, MD, MPH; Peter J. Tebben, MD; and Michael P. Whyte, MD
What does low alkaline phosphatase mean in practice? Recognize subtle signs of HPP in pediatric and adult patients and learn about the most recent treatment approvals.

New Frontiers in Osteoporosis: Targets in Bone Remodeling
ENDO Satellite Symposium | 2.0 AMA PRA Category 1 Credits™ and ABIM MOC Part 2 points
Chair: Michael R. McClung, MD
Faculty: Paul D. Miller, MD; Bente Lomholt Langdahl, PhD, DMSc; and Benjamin Zev Leder, MD
Keep up to date on the latest trials and emerging treatments in this rapidly evolving field.

Hypoparathyroidism @Point of Care
Practice Resource | Credit available
Find practical information when you need it the most to recognize signs, interpret results, and guide treatment decisions.

Osteoporosis @Point of Care
Practice Resource | Credit available
Find practical information when you need it the most to recognize signs, interpret results, and guide treatment decisions.

Bone Health Digital Toolkit
Patient Resource | No credit available
Reviewer: Ramon E. Martinez, MD
Check out interactive and downloadable resources and information for patients with questions about maintaining bone health and disease.

Endocrine Facts & Figures: Bone and Mineral
Research Resource | No credit available
Advisory Panel Chair: Robert A. Vigersky, MD
Updated epidemiological data and in-depth discussion on disorders of bone and mineral metabolism with current citations and expert insights.

Explore highlights of current publications across the Endocrine Society journals. Visit academic.oup.com/endocrinesociety for more.


Primary Aldosteronism as a Risk Factor for Vertebral Fracture
JCEM | February 09, 2017
Masakazu Notsu, Mika Yamauchi, Masahiro Yamamoto, Kiyoko Nawata, and Toshitsugu Sugimoto
Some observational studies have revealed an association between excessive aldosterone levels and reduced bone mineral density…

Influence of Premature Mortality on the Link Between Type 2 Diabetes and Hip Fracture: The Fremantle Diabetes Study
JCEM | November 23, 2016
Emma Hamilton, Wendy A. Davis, David G. Bruce, and Timothy M. E. Davis
There is consistent evidence that type 2 diabetes is associated with an increased incidence of hip fracture…

Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation during Pregnancy
JCEM | October 28, 2016
Rebecca J. Moon, Nicholas C. Harvey, Cyrus Cooper, Stefania D'Angelo, Sarah R. Crozier, Hazel M. Inskip, Inez Schoenmakers, Ann Prentice, Nigel K. Arden, Nicholas J. Bishop, Andrew Carr, Elaine M. Dennison, Richard Eastell, Robert Fraser, Saurabh V. Gandhi, Keith M. Godfrey, Stephen Kennedy, M. Zulf Mughal, Aris T. Papageorghiou, David M. Reid, Sian M. Robinson, and M. Kassim Javaid
Context: Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. Objective: We assessed which maternal and…

Genetic Variants in the Vitamin D Pathway, 25(OH)D Levels, and Mortality in a Large Population-Based Cohort Study
JCEM | October 12, 2016
José Manuel, Ordóñez-Mena, Haifa Maalmi, Ben Schöttker, Kai-Uwe Saum, Bernd Holleczek, Thomas J. Wang, Barbara Burwinkel, and Hermann Brenner
Over the last 10 years, several epidemiological studies have suggested that low vitamin D status influences the risk…

Stress Fractures: Concepts and Therapeutics
JCEM | October 12, 2016
Carolina A. Moreira and John P. Bilezikian
When bones are stressed beyond the limit of their capacity to bear a mechanical load, fractures result. This imbalance…

Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts
Endocrinology | September 30, 2017
Zhu Li, Julie L. Frey, G. William Wong, Marie-Claude Faugere, Michael J. Wolfgang, Jason K. Kim, Ryan C. Riddle, and Thomas L. Clemens
Recent studies have identified the osteoblast as an insulin responsive cell that participates in global energy homeostasis. Here, we show that glucose transporter-4 (Glut4) is required for insulin-dependent uptake…

Intraoperative Real-Time Localization of Normal Parathyroid Glands with Autofluorescence Imaging
JCEM | September 20, 2016
Sung Won Kim, Seo Hyun Song, Hyoung Shin Lee, Woong Jae Noh, Chulho Oak, Yeh-Chan Ahn, and Kang Dae Lee
Context: This biomedical investigation is valuable for identification and localization of parathyroid glands during thyroidectomy, which can provide an intraoperative real-time visual guidance. Objective: The…

The Prevalence of GNAS Deficiency-Related Diseases in a Large Cohort of Patients Characterized by the EuroPHP Network
JCEM | July 18, 2016
Francesca Marta Elli, Agnès Linglart, Intza Garin, Luisa de Sanctis, Paolo Bordogna, Virginie Grybek, Arrate Pereda, Federica Giachero, Elisa Verrua, Patrick Hanna, Giovanna Mantovani, and Guiomar Perez de Nanclares
The clinical condition resulting from end-organ resistance to PTH, first described in the early 1940s in patients with hypocalcemia and hyperphosphatemia in the absence of vitamin D deficiency…

Differential Responses to Vitamin D2 and Vitamin D3 Are Associated With Variations in Free 25-Hydroxyvitamin D
Endocrinology | July 13, 2016
Rene F. Chun, Ivan Hernandez, Renata Pereira, Leon Swinkles, Tonnie Huijs, Rui Zhou, Nancy Q. Liu, Albert Shieh, Miriam Guemes, Sanjay M. Mallya, John S. Adams, and Martin Hewison
n recent years there has been considerable debate concerning the role of vitamin D in human health. A key feature of this has been the definition of optimal levels of vitamin D and the potential…

Hormone Replacement Therapy versus the Combined Oral Contraceptive Pill in Premature Ovarian Failure: A Randomized Controlled Trial of the Effects on Bone Mineral Density
JCEM | June 24, 2016
Beth Cartwright, Jillian Robinson, Paul T. Seed, Ignac Fogelman and Janice Rymer
Context: Women with premature ovarian failure (POF) face many years of estrogen deficiency. One of the major consequences is bone loss. The optimal form of estrogen replacement…

For a complete list of Endocrine Society guidelines, visit endocrine.org/guidelines.


Paget's Disease of Bone
JCEM | November 19, 2014
Frederick R. Singer, Henry G. Bone III, David J. Hosking, Kenneth W. Lyles, Mohammad Hassan Murad, Ian R. Reid, and Ethel S. Siris
We recommend that plain radiographs be obtained of the pertinent regions of the skeleton in patients with suspected Paget's disease. If the diagnosis is confirmed…

Osteoporosis in Men
JCEM | July 02, 2013
Nelson B. Watts, Robert A. Adler, John P. Bilezikian, Matthew T. Drake, Richard Eastell, Eric S. Orwoll, and Joel S. Finkelstein
Osteoporosis in men causes significant morbidity and mortality. We recommend testing higher risk men [aged 70 and men aged 50–69 who have risk factors…

Evaluation, Treatment, and Prevention of Vitamin D Deficiency
JCEM | June 06, 2011
Michael F. Holick, Neil C. Binkley, Heike A. Bischoff-Ferrari, Catherine M. Gordon, David A. Hanley, Robert P. Heaney, M. Hassan Murad, and Connie M. Weaver
Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recommended supplementation at…

For additional meetings, visit the Endocrine Society's Worldwide Endocrinology Calendar at endocrine.org/calendar.


8th International Conference on Children's Bone Health
Dates: June 10 - 13, 2017
Location:Würzburg, Germany

Endocrine Fellows Series: Osteoporosis and Metabolic Bone Diseases
Sponsor: ICCBH
Dates: August 2 - 3, 2017
Location: Santa Fe, New Mexico, United States
Sponsor: Endocrine Society

American Society for Bone and Mineral Research 2017 Annual Meeting
Dates: September 8 - 11, 2017
Location: Colorado Convention Center, Denver, Colorado, United States
Sponsor: American Society for Bone and Mineral Research

Clinical Endocrinology Update & Endocrine Board Review
Dates: September 23–27, 2017
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
Whether you need the latest clinical information or you’re preparing to certify or recertify for the boards, Clinical Endocrinology Update (CEU) and Endocrine Board Review (EBR) have you covered.

27th International Conference on Osteoporosis
Dates: December 4-5, 2017
Sponsor: Pulsus Group
Location: Madrid, Spain

World Congress on Osteoporosis Osteoarthritis and Musculoskeletal Diseases
Dates: April 19-22, 2018
Sponsor: European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and International Osteoporosis Foundation (IOF)
Location: Krakow, Poland

Resources