Female ReproAdvancing Research and Ensuring Reproductive Health

Explore recent research and guidelines on factors impacting fertility, reproductive health, and aging in women.

Treating Polycystic Ovary Syndrome Early May Help Prevent Later Drop in Fertility
April 4, 2017 | In adolescent girls with polycystic ovary syndrome (PCOS), bringing the amount of abdominal visceral fat and liver fat down to normal restores ovulation, normalizes the symptoms…

New Natural Estrogen-Progesterone Capsule Reduces Postmenopausal Hot Flashes
April 3, 2017 | A natural, or bioidentical, combined estradiol-progesterone capsule (TX-001HR) significantly decreases the frequency and severity of moderate to severe hot flashes…

Alcohol Abuse Even Before Pregnancy May Harm Offspring
April 2, 2017 | Mothers who binge drink before they become pregnant may be more likely to have children with high blood sugar and other changes in glucose function…

Many Transgender Individuals Consider Their Fertility Important, Survey Shows
April 2, 2017 | Nearly one-fourth of transgender individuals in Toronto, Canada, regard their own fertility as important, but most lack knowledge regarding and access to reproductive options…

Decision-Tree Tool Can Help Screen Women with Gestational Diabetes for Sleep Apnea
April 1, 2017 | Healthcare providers can use a decision-tree tool to screen women who have gestational diabetes (GDM) for obstructive sleep apnea (OSA), new research from Thailand reports…

Endocrine Society Experts Issue Clinical Practice Guideline on Hypothalamic Amenorrhea
March 22, 2017 | Female athletes and women who have eating disorders are prone to developing a condition called hypothalamic amenorrhea that causes them to stop menstruating. The Endocrine Society today issued…

Tri-Point: The Genetics and Epigenetics of Puberty
January 2017 | In 2005, the editors of Science, celebrating the journal’s 125th anniversary, posed 125 unanswered questions that it predicted would fuel active research…

Survey: Endocrinologists Want Training in Transgender Care
January 10, 2017 | Four out of five physicians who specialize in treating hormone health conditions have never received formal training on care for transgender individuals, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism

Women Dissatisfied with Long Process to Diagnose Polycystic Ovary Syndrome
December 1, 2016 | International survey finds many wait years for diagnosis of common reproductive, metabolic health problem. A large international survey of women with a common condition called…

Endocrine Society Meets with NIH Office of Research on Women’s Health to Discuss Research Gaps & Policy Priorities
December 2016 | On Thursday, December 1, Janine Austin Clayton, MD, director of the NIH Office of Research on Women’s Health (ORWH) and associate director of Women’s Health Research…

Explore highlights of current education across the Endocrine Society.


Gender-Affirming Endocrine Care of Transgender and Gender Non-Binary People
ENDO Session | No credit available
Guy G. T'Sjoen, MD, PhD
Are you prepared to deliver essential endocrine care to this under-served and often misunderstood patient population?

Transitions of Care: Turner Syndrome
Practice Resource | No credit available
Resources for you and your patients to facilitate the challenging transition from pediatric to adult endocrine practice.

Women’s Health Digital Toolkit
Patient Resource | No credit available
Reviewer: Genevieve S Neal-Perry, MD, PhD
Interactive and downloadable resources and information for patients with questions related to women’s health including menopause, bone loss, and estrogen.

Explore highlights of current publications across the Endocrine Society journals. Visit academic.oup.com/endocrinesociety for more.


Whole-exome Sequencing for Diagnosis of Turner Syndrome: Towards Next Generation Sequencing and Newborn Screening
JCEM | January 24, 2017
David R. Murdock, Frank X. Donovan, Settara C. Chandrasekharapp, Nicole Banks, Carolyn Bondy, Maximilian Muenke, and Paul Kruszka
Context: Turner syndrome (TS) is due to a complete or partial loss of an X chromosome in females and is not currently part of newborn screening…

Maternal Cortisol During Pregnancy and Infant Adiposity: A Prospective Investigation
JCEM | December 23, 2016
Sonja Entringer, Claudia Buss, Jerod M. Rasmussen, Karen Lindsay, Daniel L. Gillen, Dan M. Cooper, and Pathik D. Wadhwa
Obesity represents one of the most urgent national and global health challenges because of its high prevalence and established health risks. Childhood obesity is a particularly grave concern…

Progesterone Receptors and Proliferation of the Endometrium in Obese Women With Polycystic Ovary Syndrome—A Lifestyle Intervention Study
JCEM | December 20, 2016
Mariana Paulson, Lena Sahlin, and Angelica Lindén Hirschberg
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine metabolic disorder. It affects about 10% of fertile age women and is characterized…

Gestational Hyperandrogenism in Developmental Programming
Endocrinology | December 14, 2016
Christopher Hakim, Vasantha Padmanabhan, and Arpita K. Vyas
Developmental programming is a complex process whereby perturbed intrauterine environment during a critical…

Delayed Diagnosis and a Lack of Information Associated With Dissatisfaction in Women With Polycystic Ovary Syndrome
JCEM | December 01, 2016
Melanie Gibson-Helm, Helena Teede, Andrea Dunaif, and Anuja Dokras
Polycystic ovary syndrome (PCOS) is an endocrine condition affecting 9% to 18% of reproductive-aged women…

The Steroidogenic Acute Regulatory Protein (StAR) Is Regulated by the H19/let-7 Axis
Endocrinology | November 04, 2016
Yi Men, Yanhong Fan, Yuanyuan Shen, Lingeng Lu, and Amanda N. Kallen
Tight spatiotemporal control of steroid production is essential for multiple processes involved in reproduction and fertility…

Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation during Pregnancy
JCEM | October 28, 2016
Rebecca J. Moon, Nicholas C. Harvey, Cyrus Cooper, Stefania D'Angelo, Sarah R. Crozier, Hazel M. Inskip, Inez Schoenmakers, Ann Prentice, Nigel K. Arden, Nicholas J. Bishop, Andrew Carr, Elaine M. Dennison, Richard Eastell, Robert Fraser, Saurabh V. Gandhi, Keith M. Godfrey, Stephen Kennedy, M. Zulf Mughal, Aris T. Papageorghiou, David M. Reid, Sian M. Robinson, and M. Kassim Javaid
Context: Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. Objective: We assessed which maternal and…

Cross-Sex Hormone Treatment and Psychobiological Changes in Transsexual Persons: Two-Year Follow-Up Data
JCEM | October 4, 2016
Alessandra D. Fisher, Giovanni Castellini, Jiska Ristori, Helen Casale, Emanuele Cassioli, Carolina Sensi, Egidia Fanni, Ann Maria Letizia Amato, Eva Bettini, Maddalena Mosconi, Davide Dèttore, Valdo Ricca, and Mario Maggi
Gender dysphoria (GD) is characterized by a marked incongruence between one’s experienced/expressed gender and the assigned one, associated with clinically significant distress or impairment in social, occupational, or other important areas of functioning (1). Because GD can occur with different levels of intensity, a flexible…

Independent Contributions of Nocturnal Hot Flashes and Sleep Disturbance to Depression in Estrogen-Deprived Women
JCEM | September 28, 2016
Hadine Joffe, Sybil L. Crawford, Marlene P. Freeman, David P. White, Matt T. Bianchi, Semmie Kim, Nicole Economou, Julie Camuso, Janet E. Hall, and Lee S. Cohen
Context: Women are at increased risk for mood disturbance during the menopause transition. Hot flashes (HFs), sleep disruption, and fluctuating estradiol levels correlate with menopause-associated depression…

Identification of Multiple Gene Mutations Accounts for a new Genetic Architecture of Primary Ovarian Insufficiency
JCEM | September 7, 2016
Justine Bouilly, Isabelle Beau, Sara Barraud, Valérie Bernard, Kemal Azibi, Jérôme Fagart, Anne Fèvre, Anne Laure Todeschini, Reiner A. Veitia, Chérif Beldjord, Brigitte Delemer, Catherine Dodé, Jacques Young, and Nadine Binart
Context: Idiopathic primary ovarian insufficiency (POI) is a major cause of amenorrhea and infertility. POI affects 1% of women before age 40 years, and several…

Leukemia Inhibitory Factor Is Necessary for Ovulation in Female Rhesus Macaques
Endocrinology | August 26, 2016
Melinda J. Murphy, Nathan G. Halow, Pamela A. Royer, and Jon D. Hennebold
Although the requirement of pituitary-derived LH for ovulation is well documented, the intrafollicular paracrine and autocrine processes elicited by LH necessary for follicle rupture…

For a complete list of Endocrine Society guidelines, visit endocrine.org/guidelines.


Hypothalamic Amenorrhea
JCEM | March 22, 2017
Catherine M. Gordon, Kathryn E. Ackerman, Sarah L. Berga, Jay R. Kaplan, George Mastorakos, Madhusmita Misra, M. Hassan Murad, Nanette F. Santoro, and Michelle P. Warren
FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. Investigations should include assessment of systemic and endocrinologic etiologies…

Treatment of Symptoms of the Menopause
JCEM | October 7, 2015
Cynthia A. Stuenkel, Susan R. Davis, Anne Gompel, Mary Ann Lumsden, M. Hassan Murad, JoAnn V. Pinkerton, and Richard J. Santen
Menopausal hormone therapy (MHT) is the most effective treatment for vasomotor symptoms and other symptoms of the climacteric. Benefits may exceed risks for the majority…

Androgen Therapy in Women: A Reappraisal
JCEM | October 3, 2014
Margaret E. Wierman, Wiebke Arlt, Rosemary Basson, Susan R. Davis, Karen K. Miller, Mohammad H. Murad, William Rosner, and Nanette Santoro
We continue to recommend against making a diagnosis of androgen deficiency syndrome in healthy women because there is a lack of a well-defined syndrome, and…

Diagnosis and Treatment of Polycystic Ovary Syndrome
JCEM | November 20, 2013
Richard S. Legro, Silva A. Arslanian, David A. Ehrmann, Kathleen M. Hoeger, M. Hassan Murad, Renato Pasquali, and Corrine K. Welt
We suggest using the Rotterdam criteria for diagnosing PCOS (presence of two of the following criteria: androgen excess, ovulatory dysfunction, or polycystic ovaries). Establishing a…

Endocrine Treatment of Transsexual Persons
JCEM | April 30, 2011
Wylie C. Hembree, Peggy Cohen-Kettenis, Henriette A. Delemarre-van de Waal, Louis J. Gooren, Walter J. Meyer, III, Norman P. Spack, Vin Tangpricha, and Victor M. Montori
Transsexual persons seeking to develop the physical characteristics of the desired gender require a safe, effective hormone regimen that will 1) suppress endogenous hormone secretion…

Evaluation and Treatment of Hirsutism in Premenopausal Women
JCEM | January 14, 2009
Kathryn A. Martin, R. Jeffrey Chang, David A. Ehrmann, Lourdes Ibanez, Rogerio A. Lobo, Robert L. Rosenfield, Jerry Shapiro, Victor M. Montori, and Brian A. Swiglo
We suggest testing for elevated androgen levels in women with moderate or severe hirsutism or hirsutism of any degree when it is sudden in onset, rapidly progressive…

For additional meetings, visit the Endocrine Society’s Worldwide Endocrinology Calendar at endocrine.org/calendar.


7th International IVI Congress
Dates: May 11 - 13, 2017
Location: Bilbao, Spain
Sponsor: IVI Congress

Society for the Study of Reproduction 2017 Annual Meeting
Dates: July 13 - 16, 2017
Location: Washington, DC, United States
Sponsor: Society for the Study of Reproduction

Clinical Endocrinology Update & Endocrine Board Review
Dates: September 23–27, 2017
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
Whether you need the latest clinical information or you’re preparing to certify or recertify for the boards, Clinical Endocrinology Update (CEU) and Endocrine Board Review (EBR) have you covered.

ART World Congress
Dates: October 25-26, 2017
Sponsor: CME Congresses Ltd.
Location: New York, New York, United States

2017 American Society for Reproductive Medicine Congress and Expo
Dates: October 28 - November 1, 2017
Location: Washington, DC, United States
Sponsor: American Society for Reproductive Medicine

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