Endocrine-disrupting chemicals (EDCs) are chemicals that mimic, block, or interfere with hormones in the body's endocrine system. EDCs have been associated with a diverse array of health issues. Watch an animated overview to learn more and explore the rest of the Society's education, resources, and advocacy campaigns on EDCs.


Pyrethroid Pesticide Exposure Appears to Speed Puberty in Boys
April 1, 2017 | Environmental exposure to common pesticides may cause boys to reach sexual maturity earlier, researchers have found…

Exposure to BPA Substitute, BPS, Multiplies Breast Cancer Cells
April 1, 2017 | Bisphenol S (BPS), a substitute for the chemical bisphenol A (BPA) in the plastic industry, shows the potential for increasing the aggressiveness of breast cancer through its behavior as an endocrine-disrupting chemical…

Early-Life BPA Exposure Reprograms Gene Expression Linked to Fatty Liver Disease
April 1, 2017 | Exposure during infancy to the common plasticizer bisphenol A (BPA) “hijacks” and reprograms genes in the liver of newborn rats, leading to nonalcoholic fatty liver disease…

Exposure to Common Flame Retardants May Raise the Risk of Papillary Thyroid Cancer
April 1, 2017 | Some flame retardants used in many home products appear to be associated with the most common type of thyroid cancer, papillary thyroid cancer (PTC), according to a new study…

European Commission's Revised Proposal Limits Ability to Protect Public from Endocrine-Disrupting Chemicals
February 14, 2017 | The Endocrine Society expressed disappointment today in the European Commission's revised proposal on defining and identifying endocrine-disrupting chemicals (EDCs), citing unnecessarily narrow criteria for identifying EDCs…

Prenatal Bisphenol A Exposure Weakens Body's Fullness Cues
February 07, 2017 | An expectant mother’s exposure to the endocrine-disrupting chemical bisphenol A (BPA) can raise her offspring’s risk of obesity by reducing sensitivity to leptin, a hormone responsible for controlling appetite...

Chemical Exposure Linked to Lower Vitamin D Levels
September 20, 2016 | Endocrine-disrupting chemicals may alter active form of vitamin in body. Exposure to bisphenol A (BPA) and other endocrine-disrupting chemicals (EDCs) may reduce levels of vitamin D…

Congressional Briefing Warns of Dangers of Endocrine disrupting Chemicals
September 20, 2016 | Endocrine Society calls for stronger policies to protect public health. To mark 25 years of research into chemicals that disrupt the body’s hormones, the Endocrine Society…

Fracking Chemicals Exposure May Harm Fertility in Female Mice
August 25, 2016 | Endocrine-disrupting chemicals linked to altered hormone levels, ovarian development. Prenatal exposure to chemicals used in hydraulic fracturing, or fracking, may threaten fertility in female mice…

Introduction to Endocrine-Disrupting Chemicals:
A Guide for Public Interest Organizations and Policymakers

The Endocrine Society and IPEN developed this guide to raise global awareness about endocrine-disrupting chemicals (EDCs) by presenting a comprehensive picture of global exposures and health risks. The guide is available in several languages including:

Endocrine Society Position Statements
Position statements are official points of view or beliefs of the Endocrine Society. Statements are issued on scientific or medical issues related to endocrine research and practice in our effort to ensure policy decisions are based on the full body of available knowledge. Below are position statements related to endocrine-disrupting chemicals where we advocate for greater research and updated regulatory processes to affect positive change. You may also view our complete list of position statements.

Endocrine Society Policy Recommendations
The Society produces a range of alerts, letters to officials, and testimony transcripts in an ongoing effort to influence public policy related to research and clinical endocrinology issues.

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
Endocrine Reviews | November 6, 2015
Andrea C. Gore, V. A. Chappell, S. E. Fenton, J. A. Flaws, A. Nadal, G. S. Prins, J. Toppari, and R. T. Zoeller
The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease…

Perinatal Exposure to Low-Dose Bisphenol-A Disrupts the Structural and Functional Development of the Hypothalamic Feeding Circuitry
Endocrinology | February 7, 2017
Harry MacKay, Zachary R. Patterson, Alfonso Abizaid
Bisphenol-A (BPA) is a component of polycarbonate and other plastics to which humans are regularly exposed at low levels. BPA is characterized as an endocrine disruptor because of observations of its estrogenic activity…

Multi- and Transgenerational Consequences of Bisphenol A on Sexually Dimorphic Cell Populations in Mouse Brain
Endocrinology | November 14, 2016
Jessica A. Goldsby, Jennifer T. Wolstenholme, Emilie F. Rissman
Bisphenol A (BPA) is an endocrine-disrupting compound used to manufacture plastics; it is present in linings of food cans, bottles, thermal receipts, and many other…

Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice
Endocrinology | September 1, 2016
Christopher D. Kassotis, John J. Bromfield, Kara C. Klemp, Chun-Xia Meng, Andrew Wolfe, R. Thomas Zoeller, Victoria D. Balise, Chiamaka J. Isiguzo, Donald E. Tillitt, and Susan C. Nagel
Unconventional oil and gas operations using hydraulic fracturing can contaminate surface and groundwater with endocrine-disrupting chemicals. We have previously shown that 23 of 24 commonly…

Minireview: Epigenomic Plasticity and Vulnerability to EDC Exposures
Molecular Endocrinology | August 1, 2016
Cheryl Lyn Walker
The epigenome undergoes significant remodeling during tissue and organ development, which coincides with a period of exquisite sensitivity to environmental exposures. In the case of…

Minireview: Endocrine Disruptors: Past Lessons and Future Directions
Molecular Endocrinology | July 19, 2016
Thaddeus T. Schug, Anne F. Johnson, Linda S. Birnbaum, Theo Colborn, Louis J. Guillette Jr., David P. Crews, Terry Collins, Ana M. Soto, Frederick S. vom Saal, John A. McLachlan, Carlos Sonnenschein, and Jerrold J. Heindel
Within the past few decades, the concept of endocrine-disrupting chemicals (EDCs) has risen from a position of total obscurity to become a focus of dialogue…

Female Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union
JCEM | April 1, 2016
Patricia A. Hunt, Sheela Sathyanarayana, Paul A. Fowler, and Leonardo Trasande
A growing body of evidence suggests that endocrine-disrupting chemicals (EDCs) contribute to female reproductive disorders. To calculate the associated combined health care and economic costs…

Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk
JCEM | September 1, 2015
Suzanne E. Fenton and Linda S. Birnbaum
The role of the chemical environment in disease initiation or progression is becoming more evident. Endocrine disruption via environmental chemicals is now well documented in humans…

Prenatal Programming and Endocrinology
Endocrinology | August 4, 2015
Andrea C. Gore
The endocrine system is one of the body's interfaces with the environment, together with the nervous and immune systems. These interacting physiological units evolved…

Estimating Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union
JCEM | April 1, 2015
Leonardo Trasande, R. Thomas Zoeller, Ulla Hass, Andreas Kortenkamp, Philippe Grandjean, John Peterson Myers, Joseph DiGangi, Martine Bellanger, Russ Hauser, Juliette Legler, Niels E. Skakkebaek, and Jerrold J. Heindel
Rapidly increasing evidence has documented that endocrine-disrupting chemicals (EDCs) contribute substantially to disease and disability. The objective was to quantify a range of health and economic…

Expression and Potential Roles of Pregnane X Receptor in Endometrial Cancer
JCEM | September 1, 2003
Hisashi Masuyama, Yuji Hiramatsu, Jun-ichi Kodama, and Takafumi Kudo
Estrogen has been shown to contribute greatly to growth and development in endometrial cancer. And recent research has suggested that intratumoral production of estrogen may…

Coming Soon – ENDO 2017 Session
Endocrine Disrupting Chemicals: More Fracking Bad News

ENDO Session | No credit available
Chairs: Peter Ebeling, MBBS, Monash University and Jorma Toppari, MD, PhD, University of Turku

Endocrine Society's New EDC Scientific Statement: Do We Have a Critical Mass of Science?
ENDO Session | No credit available
Andrea C. Gore, PhD, University of Texas-Austin, Austin, TX

The Economic Costs of EDCs
ENDO Session | No credit available
Leonardo Trasande, MD, MPP, NYU School of Medicine, New York, NY

Contrasting Perspectives on EDCs from Different Science Domains: Regulatory Needs
ENDO Session | No credit available
David J. Dix, PhD, US Environmental Protection Agency, Washington, DC

Contrasting Perspectives on EDCs from Different Science Domains: Clinical Endocrinology
ENDO Session | No credit available
Jorma Toppari, MD, PhD, University of Turku, Turku, Finland

Contrasting Perspectives on EDCs from Different Science Domains - Basic Endocrinology
ENDO Session | No credit available
R. Thomas Zoeller, MS, PhD, Univ of Massachusetts, Amherst, MA

Epigenetic Basis of Mammary and Testicular Development: Interaction of Diet and Environmental Exposures
ENDO Session | No credit available
Shuk-Mei Ho, PhD, University of Cincinnati, Cincinnati, OH

EDC Whiteboard Animation
Watch an animated overview of endocrine-disrupting chemicals brought to you in collaboration with the Hormone Health Network.

Hormones and EDCs
What do you need to know about endocrine-disrupting chemicals (EDCs) and your body’s endocrine system? Learn about the impact of EDCs in this infographic and share with others.

The Five W’s of EDCs
Download and share this infographic on common questions about endocrine-disrupting chemicals.

EDCs Myth vs. Fact
There’s a lot of mixed information on endocrine-disrupting chemicals (EDCs). Visit the Hormone Health Network to learn about common myths of where EDCs can be found and how they can affect you.

Test Your Knowledge
What’s your score? Take this quiz to see what you do (and don’t) know about endocrine-disrupting chemicals (EDCs).

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