ObesitySupporting Advances in Understanding, Preventing, and Treating Obesity

Learn about the causes and considerations when treating obesity, and hear about research, healthcare, and policy are changing the landscape.

Five-Year Results of STAMPEDE Trial Show Bariatric Surgery’s Efficacy on Treating T2D
March 2017 | Researchers at Cleveland Clinic last month published the five-year results of STAMPEDE, a groundbreaking trial that compared intensive medical treatment and surgical treatment of uncontrolled type 2 diabetes (T2D). The results…

Easing the Burden of Childhood Obesity
March 2017 | According to the Endocrine Society’s Facts and Figures report on Obesity, 16.9% of U.S. children age 2 to 19 years are obese, having a body mass index (BMI) at or above the 95th percentile for age and sex…

Prenatal Bisphenol A Exposure Weakens Body's Fullness Cues
February 07, 2017 | An expectant mother’s exposure to the endocrine-disrupting chemical bisphenol A (BPA) can raise her offspring’s risk of obesity by reducing sensitivity to leptin, a hormone responsible for controlling appetite...

Endocrine Society Experts Issue Clinical Practice Guideline on Pediatric Obesity
January 31, 2017 | The Endocrine Society today issued a Clinical Practice Guideline advising healthcare providers on how to prevent and treat childhood obesity with lifestyle changes...

Sweet & Lowdown: Artificial Sweeteners & Weight Gain
January 2017 | A patient asks: “Do you recommend the use of artificial sweeteners, as in diet sodas, for weight loss?”…

Gut Bacteria Differ Between Obese and Lean Youth
September 20, 2016 | Study is first to find link between gut flora and fat distribution in children, teens. Children and teenagers who are obese have different microorganisms living…

Forbidden Fruits: The Endocrine-Disrupting Threat of “Obesogens”
August 2016 | Endocrine-disrupting chemicals known as “obesogens,” found in many fungicides, have been shown to alter the function of fat cells in animal studies. Are fruits and vegetables…

Hunt for New Obesity Pills | BBC News
March 2015 | Two promising approaches to finding effective weight loss drugs have been presented at the annual meeting of the Endocrine Society. Animals given one experimental drug…

Obesity Management: Optimizing Care of Your Patients
CEU Satellite Symposium | 1.0 AMA PRA Category 1 Credits™
Ken Fujioka, MD
Follow patient cases to learn tactics to assess and treat your patients with obesity, as well as useful communication approaches.

Incorporating Lifestyle Changes into Obesity Management
ENDO Session | No credit available
Daniel H. Bessesen, MD
Practical tactics to have productive conversations and counsel your patient to overcome the significant challenges in changing lifestyle.

Treatment of Obesity in Diabetes
ENDO Session | No credit available
W. Timothy Garvey, MD
“Diabetes is not an isolated entity.” Learn clinical relationships between obesity and diabetes that influence treatment strategies in the larger spectrum of cardiometabolic disease.

Mechanisms Underlying Weight Loss with Bariatric Surgery: Lessons from Animal Models
ENDO Session | No credit available
Randy J. Seeley, PhD
Hear how animal models are shedding light on how bariatric surgery affect weight loss as well as many other metabolic outcomes.

Genetic Contributions to Outcomes after Bariatric Surgery
ENDO Session | No credit available
Lee M. Kaplan, MD, PhD
Learn about genetic studies being used to understand the underlying effects of metabolic surgery and act as clinical outcome predictors.

Endocrine Facts & Figures: Obesity
Research Resource | No credit available
Advisory Panel Chair: Robert A. Vigersky, MD
Updated epidemiological data and in-depth discussion on obesity, metabolic syndrome, and associated comorbidities with current citations and expert insights.

Obesity Management Workshop 2016
Workshop Webcast | 9.75 AMA PRA Category 1 Credits™ and ABIM MOC Part 2 points
Planning Chairs: Richard Atkinson, Jr., MD; Daniel Bessesen, MD; Marc-Andre Cornier, MD; and William T. Donahoo, MD
Expert faculty focus on advanced practice challenges and highlight emerging therapies and strategies for preventing, diagnosing, and managing obesity.

Pediatric Obesity: The Hidden High Costs of Junk Food
Patient Resource | No credit available
Interactive and downloadable infographic for patients and caregivers with questions about how children’s food choices can affect health and healthcare costs.

Bariatric Surgery and Adolescents
Patient Resource | No credit available
Interactive and downloadable infographic for caregivers with questions about bariatric surgery is an option for their child.

GH Treatment in Children with Prader-Willi Syndrome: 3 Years Longitudinal Data in Prepubertal Children and Adult Height Data from KIGS Database
JCEM | February 16, 2017
N.E. Bakker, A. Lindberg, J. Heissler, H.A. Wollmann, C. Camacho-Hübner, and A.C. Hokken-Koelega on behalf of the KIGS Steering Committee
Context: Longitudinal data of children with Prader-Willi syndrome (PWS) treated with Genotropin were registered in Pfizer-…

Cord Blood Adipocyte Fatty Acid Binding Protein Levels Correlate With Gestational Age And Birth Weight In Neonates
JCEM | January 31, 2017
Kyoung Eun Joung, Sule Umit Cataltepe, Zoe Michael, Helen Christou, and Christos S. Mantzoros
Context: Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndrome in future life, but the underlying mechanisms…

Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health – Pooled Analysis of Two Twin Cohorts
JCEM | January 23, 2017
Sakari Jukarainen, René Holst, Christine Dalgård, Päivi Piirilä, Jesper Lundbom, Antti Hakkarainen, Nina Lundbom, Aila Rissanen, Jaakko Kaprio, Kirsten Ohm Kyvik, Thorkild I.A. Sørensen, and Kirsi H. Pietiläinen
Context: The joint effects of cardiorespiratory fitness and body composition on metabolic health are not well known…

Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity
Endocrinology | November 16, 2016
Clinton T. Elfers and Christian L. Roth
Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase…

Genetic Variation in the 11β-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity
JCEM | October 7, 2016
Stefan Z. Lutz, Andreas Peter, Fausto Machicao, Apostolia Lamprinou, Jürgen Machann, Fritz Schick, Ingmar Königsrainer, Alfred Königsrainer, Andreas Fritsche, Harald Staiger, Hans-Ulrich Häring, Norbert Stefan, and Konstantinos Kantartzis
Acute pharmacological inhibition of 11β-hydroxysteroid-dehydrogenase 1 (11β-HSD1), which converts cortisone into the much more potent cortisol in peripheral tissues, results in reduction of total, visceral…

Free Radical-derived Oxysterols: Novel Adipokines Modulating Adipogenic Differentiation of Adipose Precursor Cells
JCEM | October 6, 2016
Giuseppe Murdolo, Marta Piroddi, Cristina Tortoioli, Desirée Bartolini, Martin Schmelz, Francesca Luchetti, Barbara Canonico, Stefano Papa, Chiara Zerbinati, Luigi Iuliano, and Francesco Galli
Increased oxidative stress in adipose tissue emerges as an inducer of obesity-linked insulin resistance. Here we tested whether free-radical derived oxysterols are formed by, and accumulate…

Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood
JCEM | September 7, 2016
Rebecca A. Ohman-Hanson, Melanie Cree-Green, Megan M. Kelsey, Daniel H. Bessesen, Teresa A. Sharp, Laura Pyle, Rocio I. Pereira, and Kristen J. Nadeau
Insulin resistance (IR) and type 2 diabetes are increasing, particularly in Hispanic (H) vs non-Hispanic White (NHW) populations. Adiponectin has a known role in IR, and therefore…

Risk Factors for Spontaneously Self-Reported Postprandial Hypoglycemia After Bariatric Surgery
JCEM | June 23, 2016
Monica Nannipieri, Anna Belligoli, Daniela Guarino, Luca Busetto, Diego Moriconi, Roberto Fabris, Andrea Mari, Simona Baldi, Marco Anselmino, Mirto Foletto, Roberto Vettor, and Ele Ferrannini
Postprandial hypoglycemia (PPHG) is a recognized complication of Roux-en-Y gastric bypass (RYGB) surgery. Data on PPHG after laparoscopic sleeve gastrectomy (LSG) are scant. The objective…

Cannabinoid Receptor 2 as Antiobesity Target: Inflammation, Fat Storage, and Browning Modulation
JCEM | June 13, 2016
F. Rossi, G. Bellini, L. Luongo, I. Manzo, S. Tolone, C. Tortora, M. E. Bernardo, A. Grandone, A. Conforti, L. Docimo, B. Nobili, L. Perrone, F. Locatelli, S. Maione, and E. Miraglia del Giudice
Obesity is associated with a low-grade inflammatory state and adipocyte (ADP) hyperplasia/hypertrophy. Obesity inhibits the “browning” of white adipose tissue. Cannabinoid receptor 2 (CB2) agonists…

Effect of Three Levels of Dietary Protein on Metabolic Phenotype of Healthy Individuals With 8 Weeks of Overfeeding
JCEM | May 9, 2016
George A. Bray, Leanne M. Redman, Lilian de Jonge, Jennifer Rood and Steven R. Smith
Context: Obesity is associated with insulin resistance and other metabolic changes that might be modified by overfeeding diets with different protein levels…

Pediatric Obesity—Assessment, Treatment, and Prevention
JCEM | January 31, 2017
Dennis M. Styne, Silva A. Arslanian, Ellen L. Connor, Ismaa Sadaf Farooqi, M. Hassan Murad, Janet H. Silverstein, and Jack A. Yanovski
Pediatric obesity remains an ongoing serious international health concern affecting about 17% of United States children and adolescents, threatening their adult health…

Pharmacological Management of Obesity
JCEM | January 15, 2015
Caroline M. Apovian, Louis J. Aronne, Daniel H. Bessesen, Marie E. McDonnell, M. Hassan Murad, Uberto Pagotto, Donna H. Ryan, and Christopher D. Still
Weight loss is a pathway to health improvement for patients with obesity-associated risk factors and comorbidities. Medications approved for chronic weight management can be useful adjuncts…

Endocrine and Nutritional Management of the Post-Bariatric Surgery Patient
JCEM | April 30, 2011
David Heber, Frank L. Greenway, Lee M. Kaplan, Edward Livingston, Javier Salvador, and Christopher Still
Bariatric surgery is not a guarantee of successful weight loss and maintenance. Increasingly, patients regain weight, especially those undergoing restrictive surgeries such as laparoscopic banding…

Metabolic Syndrome Bench to Clinic
Dates: March 11, 2017
Location: Baltimore, Maryland, United States
Sponsor: Society of Toxicology

Sex and Gender Factors Affecting Metabolic Homeostasis and Diabetes and Obesity
Dates: March 19 - 23, 2017
Location: Tahoe City, California, United States
Sponsor: Keystone Symposia on Molecular and Cellular Biology

ENDO 2017 Preconference
Androgen Excess and PCOS Society Update

Dates: March 31, 2017
Location: Orlando, Florida, United States
Sponsor: Androgen Excess and PCOS Society

Keystone Symposium on Neuronal Control of Appetite and Metabolism and Weight
Dates: May 9 - 13, 2017
Location: Copenhagen, Denmark
Sponsor: Keystone Symposia on Molecular and Cellular Biology

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