ObesitySupporting Advances in Understanding, Preventing, and Treating Obesity

Learn about the causes and considerations when treating obesity, and hear about research, healthcare, and policy are changing the landscape.

Study Finds Alzheimer's Disease Likely Not Caused by Low Body Mass Index
May 9, 2017 | A new large-scale genetic study found that low body mass index (BMI) is likely not a causal risk factor for Alzheimer’s disease, as earlier research had suggested…

Participation in a Weight Management Program Reduces Job Absenteeism
April 4, 2017 | Individuals with obesity who enrolled in a structured weight loss program report fewer hours missed from work after six months in the program, according to a study…

Urine Metabolites May Help Predict Which Obese Teens Will Develop Diabetes
April 4, 2017 | Researchers have discovered a unique metabolic “signature” in the urine of diabetic, obese black teenagers that they say may become a way to predict the development of type 2 diabetes…

Disrupted Stress Hormone Signals in Bone Cells Protect from Diet-Induced Obesity
April 4, 2017 | A high-calorie diet, even without a high amount of fat, causes bone loss, and both high-calorie and high-fat diets induce excessive fat gain and insulin resistance…

Brain Signals After a Meal Respond to Food Pictures More in Obese Than Lean Kids
April 3, 2017 | Brain signals that should help tell us we are full after eating appear to be dulled in obese children, according to preliminary results of a new study presented Monday at ENDO 2017…

Patients with Higher Thyroid Hormone Levels Lose More Weight After Bariatric Surgery
April 3, 2017 | Patients who have higher levels of the thyroid hormone triiodothyronine (T3) lose more weight after bariatric surgery, new research from Portugal reports. The study…

Magnetic Brain Stimulation Causes Weight Loss by Making Gut Bacteria Healthier
April 3, 2017 | A new study finds that a noninvasive electromagnetic brain stimulation technique helps obese people lose weight, partly by changing the composition of their intestinal bacteria&hellp;

Low-Calorie Sweeteners Promote Fat Accumulation in Human Fat
April 3, 2017 | Low-calorie, artificial sweeteners appear to play havoc with the body’s metabolism, and large consumption of these sugar substitutes could promote fat accumulation…

Five-Year Results of STAMPEDE Trial Show Bariatric Surgery’s Efficacy on Treating T2D
March 2017 | Researchers at Cleveland Clinic last month published the five-year results of STAMPEDE, a groundbreaking trial that compared intensive medical treatment and surgical treatment of uncontrolled type 2 diabetes (T2D). The results…

Easing the Burden of Childhood Obesity
March 2017 | According to the Endocrine Society’s Facts and Figures report on Obesity, 16.9% of U.S. children age 2 to 19 years are obese, having a body mass index (BMI) at or above the 95th percentile for age and sex…

Explore highlights of current education across the Endocrine Society.

Obesity Management Workshop 2016
Workshop Webcast | 9.75 AMA PRA Category 1 Credits™ and ABIM MOC Part 2 points
Planning Chairs: Richard Atkinson, Jr., MD; Daniel Bessesen, MD; Marc-Andre Cornier, MD; and William T. Donahoo, MD
Expert faculty focus on advanced practice challenges and highlight emerging therapies and strategies for preventing, diagnosing, and managing obesity.

Obesity Management: Optimizing Care of Your Patients
CEU Satellite Symposium | 1.0 AMA PRA Category 1 Credits™
Ken Fujioka, MD
Follow patient cases to learn tactics to assess and treat your patients with obesity, as well as useful communication approaches.

Incorporating Lifestyle Changes into Obesity Management
ENDO Session | No credit available
Daniel H. Bessesen, MD
Practical tactics to have productive conversations and counsel your patient to overcome the significant challenges in changing lifestyle.

Treatment of Obesity in Diabetes
ENDO Session | No credit available
W. Timothy Garvey, MD
“Diabetes is not an isolated entity.” Learn clinical relationships between obesity and diabetes that influence treatment strategies in the larger spectrum of cardiometabolic disease.

Mechanisms Underlying Weight Loss with Bariatric Surgery: Lessons from Animal Models
ENDO Session | No credit available
Randy J. Seeley, PhD
Hear how animal models are shedding light on how bariatric surgery affect weight loss as well as many other metabolic outcomes.

Genetic Contributions to Outcomes after Bariatric Surgery
ENDO Session | No credit available
Lee M. Kaplan, MD, PhD
Learn about genetic studies being used to understand the underlying effects of metabolic surgery and act as clinical outcome predictors.

Endocrine Facts & Figures: Obesity
Research Resource | No credit available
Advisory Panel Chair: Robert A. Vigersky, MD
Updated epidemiological data and in-depth discussion on obesity, metabolic syndrome, and associated comorbidities with current citations and expert insights.

Pediatric Obesity: The Hidden High Costs of Junk Food
Patient Resource | No credit available
Interactive and downloadable infographic for patients and caregivers with questions about how children’s food choices can affect health and healthcare costs.

Bariatric Surgery and Adolescents
Patient Resource | No credit available
Interactive and downloadable infographic for caregivers with questions about bariatric surgery is an option for their child.

Explore highlights of current publications across the Endocrine Society journals. Visit academic.oup.com/endocrinesociety for more.

GH Treatment in Children with Prader-Willi Syndrome: 3 Years Longitudinal Data in Prepubertal Children and Adult Height Data from KIGS Database
JCEM | February 16, 2017
N.E. Bakker, A. Lindberg, J. Heissler, H.A. Wollmann, C. Camacho-Hübner, and A.C. Hokken-Koelega on behalf of the KIGS Steering Committee
Context: Longitudinal data of children with Prader-Willi syndrome (PWS) treated with Genotropin were registered in Pfizer-…

Cord Blood Adipocyte Fatty Acid Binding Protein Levels Correlate With Gestational Age And Birth Weight In Neonates
JCEM | January 31, 2017
Kyoung Eun Joung, Sule Umit Cataltepe, Zoe Michael, Helen Christou, and Christos S. Mantzoros
Context: Infants born small for gestational age (SGA) have increased risk for obesity and metabolic syndrome in future life, but the underlying mechanisms…

Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health – Pooled Analysis of Two Twin Cohorts
JCEM | January 23, 2017
Sakari Jukarainen, René Holst, Christine Dalgård, Päivi Piirilä, Jesper Lundbom, Antti Hakkarainen, Nina Lundbom, Aila Rissanen, Jaakko Kaprio, Kirsten Ohm Kyvik, Thorkild I.A. Sørensen, and Kirsi H. Pietiläinen
Context: The joint effects of cardiorespiratory fitness and body composition on metabolic health are not well known…

Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues
Endocrinology | January 16, 2017
Rajan Singh, Melissa Braga, Srinivasa T. Reddy, Se-Jin Lee, Meher Parveen, Victor Grijalva, Laurent Vergnes, and Shehla Pervin
Obesity is a global health concern and represents a major risk factor for development of type 2 diabetes, dyslipidemia, cardiovascular disease, and…

LDB1 Regulates Energy Homeostasis During Diet – Induced Obesity
Endocrinology | December 23, 2016
Christine Loyd, Yanping Liu, Teayoun Kim, Cassie Holleman, Jamie Galloway, Maigen Bethea, Benjamin N. Ediger, Thomas A. Swain, Yawen Tang, Doris A. Stoffers, Glenn C. Rowe, Martin Young, Chad Steele, Kirk M. Habegger, and Chad S. Hunter
Obesity, imparted by reduced physical activity and a concomitant increase in high-fat food intake, has become a worldwide epidemic…

Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity
Endocrinology | November 16, 2016
Clinton T. Elfers and Christian L. Roth
Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase…

Genetic Variation in the 11β-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity
JCEM | October 7, 2016
Stefan Z. Lutz, Andreas Peter, Fausto Machicao, Apostolia Lamprinou, Jürgen Machann, Fritz Schick, Ingmar Königsrainer, Alfred Königsrainer, Andreas Fritsche, Harald Staiger, Hans-Ulrich Häring, Norbert Stefan, and Konstantinos Kantartzis
Acute pharmacological inhibition of 11β-hydroxysteroid-dehydrogenase 1 (11β-HSD1), which converts cortisone into the much more potent cortisol in peripheral tissues, results in reduction of total, visceral…

Free Radical-derived Oxysterols: Novel Adipokines Modulating Adipogenic Differentiation of Adipose Precursor Cells
JCEM | October 6, 2016
Giuseppe Murdolo, Marta Piroddi, Cristina Tortoioli, Desirée Bartolini, Martin Schmelz, Francesca Luchetti, Barbara Canonico, Stefano Papa, Chiara Zerbinati, Luigi Iuliano, and Francesco Galli
Increased oxidative stress in adipose tissue emerges as an inducer of obesity-linked insulin resistance. Here we tested whether free-radical derived oxysterols are formed by, and accumulate…

Ethnic and Sex Differences in Adiponectin: From Childhood to Adulthood
JCEM | September 7, 2016
Rebecca A. Ohman-Hanson, Melanie Cree-Green, Megan M. Kelsey, Daniel H. Bessesen, Teresa A. Sharp, Laura Pyle, Rocio I. Pereira, and Kristen J. Nadeau
Insulin resistance (IR) and type 2 diabetes are increasing, particularly in Hispanic (H) vs non-Hispanic White (NHW) populations. Adiponectin has a known role in IR, and therefore…

A Common Variant and the Transcript Levels of MC4R Gene Are Associated With Adiposity in Children: The IDEFICS Study
JCEM | September 1, 2016
Fabio Lauria, Alfonso Siani, Catalina Picó, Wolfgang Ahrens, Karin Bammann, Stefaan De Henauw, Ronja Foraita, Licia Iacoviello, Yiannis Kourides, Staffan Marild, Denes Molnar, Luis A. Moreno, Yannis Pitsiladis, Juana Sánchez, Toomas Veidebaum, Guan Wang, and Paola Russo on behalf of the IDEFICS consortium
According to the recent World Health Organization report, the prevalence of childhood obesity increased at an alarming rate during the last decades in many countries. Although the increasing rates are apparently plateauing in some Western countries, it remains a serious challenge and a public health priority…

For a complete list of Endocrine Society guidelines, visit endocrine.org/guidelines.

Pediatric Obesity—Assessment, Treatment, and Prevention
JCEM | January 31, 2017
Dennis M. Styne, Silva A. Arslanian, Ellen L. Connor, Ismaa Sadaf Farooqi, M. Hassan Murad, Janet H. Silverstein, and Jack A. Yanovski
Pediatric obesity remains an ongoing serious international health concern affecting about 17% of United States children and adolescents, threatening their adult health…

Pharmacological Management of Obesity
JCEM | January 15, 2015
Caroline M. Apovian, Louis J. Aronne, Daniel H. Bessesen, Marie E. McDonnell, M. Hassan Murad, Uberto Pagotto, Donna H. Ryan, and Christopher D. Still
Weight loss is a pathway to health improvement for patients with obesity-associated risk factors and comorbidities. Medications approved for chronic weight management can be useful adjuncts…

Endocrine and Nutritional Management of the Post-Bariatric Surgery Patient
JCEM | April 30, 2011
David Heber, Frank L. Greenway, Lee M. Kaplan, Edward Livingston, Javier Salvador, and Christopher Still
Bariatric surgery is not a guarantee of successful weight loss and maintenance. Increasingly, patients regain weight, especially those undergoing restrictive surgeries such as laparoscopic banding…

For additional meetings, visit the Endocrine Society’s Worldwide Endocrinology Calendar at endocrine.org/calendar.

Clinical Endocrinology Update & Endocrine Board Review
Dates: September 23–27, 2017
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
Whether you need the latest clinical information or you’re preparing to certify or recertify for the boards, Clinical Endocrinology Update (CEU) and Endocrine Board Review (EBR) have you covered.

ENDO Bridge
Dates: October 19–22, 2017
Location: Antalya, Turkey
Sponsor: Endocrine Society, the European Society of Endocrinology, and The Society of Endocrinology and Metabolism of Turkey
EndoBridge will provide a comprehensive update in the field of endocrinology for the clinical endocrinologist. The official language of the meeting is English, but simultaneous translation will be available in Russian, Arabic, and Turkish

ENDO 2018
Dates: March 17–20, 2018
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
ENDO is the world’s largest event for presenting and obtaining the latest in endocrine science and medicine with an extensive program covering a broad array of topics, various networking opportunities, poster sessions, updates on new products and technologies at the ENDOExpo, and more.