an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2022–2023, focused on obesity! Curation of the collection was guided by Altmetric Attention Scores, Featured Article designations, and the number of article downloads.
In Journal of the Endocrine Society, Enright and coauthors discuss the advent of new weight-loss pharmacotherapies and their potential to move beyond the 5 percent goal. Schweitzer and colleagues describe weight loss and blood lipid as well as HbA1c improvements resulting from a short-term workplace-based diet and exercise program (Pritkin). Endo et al. report on studies with male mice indicating that the metabolic benefits of intermittent fasting result in part from promotion of histone acetylation in lipid oxidation genes of muscle and adipose tissue.
In JCEM Case Reports, Patel and coauthors report on a young man who achieved a 32.5 percent weight loss with a combination of drug therapies, including a glucagon-like peptide-1 receptor agonist. Farabi et al. describe the case of a young woman whose body weight increased by over 30 percent with no concomitant worsening of her metabolic health. Sciacovelli and associates report on the successful use of semaglutide to treat obesity induced by resection of craniopharyngioma.
In Endocrine Reviews, Akalestou and others survey mechanisms of weight loss after obesity surgery, which include changed food selection. Carpentier and associates discuss the cellular metabolism of brown adipose tissue, its regulation, and its likely roles in human thermoregulation and cardiometabolic disorders — as well as the potential for its therapeutic manipulation. Brown and Scherer critically review the evidence linking adiposity with 13 types of cancer, discussing several possible mechanisms for the connection.
In Endocrinology, Kumagai and coauthors describe a multi-omics atlas that integrates transcriptomic and metabolomic characterizations of mouse brown adipose tissue over the life span to obtain a time-resolved picture of its development. Li and colleagues identify mechanisms that may account for the weight-loss-inducing effects of berberine. Smith and others provide evidence that young women are protected from the vascular insulin resistance that even short-term exposure to an obesogenic lifestyle confers on young men.
In JCEM, Kalavalapalli and associates report that the insulin resistance of adipose tissue predicts the severity of liver fibrosis in patients with type 2 diabetes and non-alcoholic fatty liver disease. Jun et al. describe how low skeletal muscle mass and abdominal obesity additively increase the risk of incident type 2 diabetes, independently from glycometabolic parameters. Mongraw-Chaffin and coauthors find a strong graded association of body mass index and diabetes with self-reported COVID-19 that suggests obesity and diabetes might play a role in risk for symptomatic SARS-CoV-2 infection, beyond their co-occurrence with socioeconomic factors.
Published: September 2023
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, The Journal of Clinical Endocrinology & Metabolism, and JCEM Case Reports so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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