Scientific Statement Scientific Statement

Hormones and Aging: An Endocrine Society Scientific Statement

June 16, 2023

Full Statement: Hormones and Aging: An Endocrine Society Scientific Statement
The Journal of Clinical Endocrinology & Metabolism, 2023
Anne R. Cappola, Richard J. Auchus, Ghada El-Hajj Fuleihan, David J. Handelsman, Rita R. Kalyani, Michael McClung, Cynthia A. Stuenkel, Michael O. Thorner, Joseph G. Verbalis


Multiple changes occur across various endocrine systems as an individual ages. The understanding of the factors that cause age-related changes and how they should be managed clinically is evolving. This statement reviews the current state of research in the growth hormone, adrenal, ovarian, testicular, and thyroid axes, as well as in osteoporosis, vitamin D deficiency, type 2 diabetes, and water metabolism, with a specific focus on older individuals. Each section describes the natural history and observational data in older individuals, available therapies, clinical trial data on efficacy and safety in older individuals, key points, and scientific gaps. The goal of this statement is to inform future research that refines prevention and treatment strategies in age-associated endocrine conditions, with the goal of improving the health of older individuals.

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About Scientific Statements

Scientific Statements educate basic scientists, clinical scientists, and clinicians on the scientific basis of disease and on how this knowledge can be applied in clinical practice. These publications provide an evidence-based overview of basic and clinical science topics and identify areas that require additional research. Topics are selected on the basis of their emerging scientific impact on disease and their clinical relevance to the general population. Scientific Statements are developed by a multidisciplinary Task Force of experts with representation from several committees within the Endocrine Society.

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