"The Endocrine Society appreciates the opportunity to comment on the “European Chemical Agency proposed restriction on bisphenol A (BPA) and other bisphenols with endocrine disrupting properties for the environment.” As the world’s oldest, largest, and most active organization dedicated to the understanding of hormone systems and the clinical care of patients with endocrine diseases, we have long recognized the effects of endocrine-disrupting chemicals (EDCs) such as BPA on sensitive endocrine systems and we welcome group-based approaches to assessing and restricting bisphenols and other classes of EDCs. Such approaches are necessary to prevent harms to human and environmental health as a result of endocrine disruption, with impacts on metabolism, neurodevelopment, male and female reproduction, and other endpoints. In our comments, we propose several improvements to the proposal that reflect the state of the science on these hazardous substances."