"The Endocrine Society appreciates the opportunity to comment on the Pesticide Registration Review of dimethyl tetrachloroterephthalate (DCPA). Founded in 1916, the Endocrine Society is the world’s oldest, largest, and most active organization dedicated to the understanding of the endocrine system; what hormones are, what they do, and how they work. Our community of researchers and clinicians are advancing our understanding of how chemicals interfere with endocrine systems and act as endocrine disrupting chemicals (EDCs). We are extremely concerned about the results of the DCPA thyroid toxicity studies, which showed decreased levels of T3 and T4 in fetal rats at very low, biologically-relevant levels, indicating that this chemical is an EDC."