Meetings & Events

Thyroid Eye Disease: Early Diagnosis, Referral, and Treatment with TEPEZZA (teprotumumab-trbw)

August 26, 2021

Session Date and Time:

Sunday, September 12
10:00–10:35AM EDT

Learning Objectives:

  1. Describe the pathophysiology of Thyroid Eye Disease (TED).
  2. Review the clinical signs and symptoms of TED to ensure an early diagnosis and referral to a TED specialist.
  3. Emphasize the importance of multidisciplinary TED management.
  4. Provide an overview of TEPEZZA efficacy, safety, and mechanism of action for the treatment of TED.

This presentation is intended for US healthcare professionals.

Raymond S. Douglas, MD, PhDSession Faculty:

Raymond S. Douglas, MD, PhD | Cedars-Sinai Medical Center
Dr. Douglas is a consultant for Horizon Therapeutics and Immunovant.

Return to the full CEU 2021 program.

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Indication:

TEPEZZA is indicated for the treatment of Thyroid Eye Disease.

Important Safety Information:

Warnings and Precautions

Infusion Reactions: TEPEZZA may cause infusion reactions. Infusion reactions have been reported in approximately 4% of patients treated with TEPEZZA. Reported infusion reactions have usually been mild or moderate in severity. Signs and symptoms may include transient increases in blood pressure, feeling hot, tachycardia, dyspnea, headache, and muscular pain. Infusion reactions may occur during an infusion or within 1.5 hours after an infusion. In patients who experience an infusion reaction, consideration should be given to premedicating with an antihistamine, antipyretic, or corticosteroid and/or administering all subsequent infusions at a slower infusion rate.

Preexisting Inflammatory Bowel Disease: TEPEZZA may cause an exacerbation of preexisting inflammatory bowel disease (IBD). Monitor patients with IBD for flare of disease. If IBD exacerbation is suspected, consider discontinuation of TEPEZZA.

Hyperglycemia: Increased blood glucose or hyperglycemia may occur in patients treated with TEPEZZA. In clinical trials, 10% of patients (two-thirds of whom had preexisting diabetes or impaired glucose tolerance) experienced hyperglycemia.  Hyperglycemic events should be managed with medications for glycemic control, if necessary.  Monitor patients for elevated blood glucose and symptoms of hyperglycemia while on treatment with TEPEZZA.  Patients with preexisting diabetes should be under appropriate glycemic control before receiving TEPEZZA.

Adverse Reactions

The most common adverse reactions (incidence >5% and greater than placebo) are muscle spasm, nausea, alopecia, diarrhea, fatigue, hyperglycemia, hearing impairment, dysgeusia, headache, and dry skin.

For additional information on TEPEZZA, please see Full Subscribing Information at TEPEZZAhcp.com.

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