We are excited to announce the launch of a new initiative to share select scientific presentations from ENDO 2019 with the broader scientific community. This partnership with Keystone Symposia generated 10 sessions, featuring 27 presentations, from the ENDO 2019 Science Pathways. Two new panel discussions moderated by Gary Hammer, MD, PhD and Carolyn Smith, PhD were also specially prepared to debut in this video collection.

These presentations and panel discussions are now available and free to access. Please bookmark this page for future access to the video collection.


ENDO Panels

Regulation of Cell Growth in Cancer, Aging, and Chronic Diseases > >

Gary Hammer, MD, PhD, Moderator | Sundeep Khosla, MD, Panelist | Subhamoy Dasgupta, PhD, Panelist


Mechanisms of Gene Regulation in Development, Metabolic Regulation, and Inflammation > >

Carolyn Smith, PhD, Moderator | Peter Tontonoz, MD, PhD, Panelist | Christopher Glass, MD, PhD, Panelist | Marisa Bartolomei, PhD, Panelist


Session Videos

Basic Mechanisms in Reproductive Tissue Function

Basic Mechanisms in Reproductive Tissue Function >>

  • A Novel Mutation in the Follicle-Stimulating Hormone Receptor (Ile423Thr) in a Woman with Normal Pubertal Development and Primary Amenorrhea: In Vivo, In Vitro, and In Silico Studies | Alfredo Ulloa-Aguirre MD, DSc
  • Androgen Receptor- Vs Estrogen Receptor-Mediated Actions in the Development of Distinct Clinical Polycystic Ovary Syndrome (PCOS) Phenotypes | Kirsty Walters PhD
  • The Role Of Neuronal Plasticity In The Timing Of Puberty Onset: Insights From A Mkrn3 Deficient Mouse Model | Lydie Naule PhD

 

Maternal Fetal Interactions for Healthy Gestation >>

  • Fetal-Maternal Signaling in the Timing of Birth | Carole Mendelson PhD
  • The Role of Stem Cells in Endometrial Health and Disease | Hugh Taylor MD


Neena B. Schwartz Memorial Symposium: TGF-β Signaling in the Ovary and Uterus >>

  • Transforming Growth Factor-ß Family and Its Modulating microRNAs in Placental Development and Uterine Spiral Artery Remodeling
  • TGF-beta Signaling in Uterine Function and Disease: Insights from Genetically Modified Mouse Models

 

Genetics and Development of the Endocrine System in Health and Disease >>

  • Extreme Phenotypic Variability of a Novel Mutation of MEN1 Gene in a Family with 14 Carriers across 3 Generations
  • Human Sex Determination at the Edge of Ambiguity: Impaired SRY Phosphorylation Attenuates Expression of the Male Program
  • Long-Term Follow-Up of a Female with a Mutation in the Estrogen Receptor Alpha (ESR1) Gene


Molecular Determinants of Nuclear Receptor Function

Molecular Determinants of Nuclear Receptor Function >>

  • Posttranslational Modification of Steroid Receptors
  • Structural Studies of DNA: Nuclear Receptor Interactions
  • Structural Analysis of Nuclear Receptor Corepressor Complexes

 

New Mechanisms of Steroid Receptor Activation in Hormone-Dependent Cancers >>

  • Charting the Epigenomic Landscape of Prostate Cancer
  • ER Alterations in Endocrine Resistant Breast Cancer


New Technologies: Cellular Organization Across Time and Space >>

  • Phase Separation in the Nucleus
  • Chromatin Tracking, Receptor Mobility and Oligomerization in Live Cells

 

Pituitary Development and Tumorigenesis >>

  • Homeostatic and Tumourigenic Activity of SOX2+ Pituitary Stem Cells is Controlled by the LATS/YAP/TAZ Cascade
  • Non-syndromic Cushing's Disease Due To CDKN1B Mutations: Novel Mutations And Phenotypic Features In A Large Pediatric Cohort
  • PROP1 Directs Pituitary Differentiation through Protein Interaction and for Regulation of Gene Expression Involved in an EMT-Like Process
  • Persistence of Progenitor Cell Markers Following the Selective Ablation of Musashi in Somatotropes


GNRH Pulse Generation

Pituitary Hormone Pulse Generation: Is the Hypothalamus the Driver or the Facilitator? >>

  • Importance of ACTH Pulses for Adrenal Function
  • GNRH Pulse Generation

 

The Good, the Bad, and the Ugly: Senescence in Pituitary Tumors >>

  • Regulation of Senescence in Benign Adenoma
  • Linking Senescence and Inflammation: The Senescence-Associated Secretory Phenotype (SASP)
  • Tumor-Promoting Effects of Senescent Cells in Pituitary Tumors

 

Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists.

To learn more about Keystone Symposia, visit: keystonesymposia.org