Our popular Basic Science Pathways are back and have been enhanced to ensure your meeting experience focuses in on the topic area you need. These special “meeting within a meeting” tracks integrate focused discussions, poster sessions, and networking opportunities providing you with an ideal way to surround yourself with the latest research. View the Neuroendocrinology Pathway below and add to your meeting itinerary.
Each track will offer electronic poster previews to help facilitate the viewing of the top scoring abstracts within each topic and receptions to be held at the end of each program.
Our inaugural PANS annual meeting will be held as a satellite meeting of ENDO 2019 in New Orleans. We are excited to partner with the Endocrine Society to host a meeting featuring presentations by leading neuroendocrinologists, and at which neuroendocrine researchers and trainees can share their newest and most exciting findings. PANS2019 will take place March 21-22, 2019, immediately before ENDO 2019. We encourage everyone to enjoy the dual networking activities by attending both of these world-class meetings. Symposia at PANS2019 will focus on four integrated topics that cross traditional neuroendocrine boundaries, including: epigenetic regulation of endocrine signaling; functional investigation of neuroendocrine circuits; circadian and metabolic control of neuroendocrine function; and neuroinflammation and neural injury in neuroendocrine states. Our keynote speaker will be Dr. Margaret M. McCarthy, world-renowned behavioral neuroendocrinologist. Without a doubt, this will be the event of the year for neuroendocrinologists, and we invite all to attend. Hope to see you in New Orleans in March 2019!
Additional registration required for this session.
Fetal Programming of the HPA Axis Rebecca M. Reynolds, MD, PhD—University of Edinburgh
How Stress Systems Interact with Circadian Rhythms Robert L. Spencer, PhD—University of Colorado Boulder
Impact of Diet on the HPA Axis Yvonne M. Ulrich-Lai, PhD—University of Cincinnati
(S) Management of Aggressive Pituitary Lesions (4:15 PM–5:45 PM) Chair: Vera Popovic-Brkic, MD, PhD—Medical Faculty University of Belgrade This session will focus on recent advances in understanding the pathology, treatment effectiveness, and management of aggressive pituitary tumors and carcinomas.
Aggressive Pituitary Tumors and Carcinomas: Two Sides of the Same Coin? Jacqueline Trouillas MD, PhD—University of Lyon
Treatment of Aggressive Pituitary Tumors and Carcinomas Ann I. McCormack, MD—St. Vincent's Hospital
Molecular Underpinnings of the Aggressive Pituitary Tumor Gerald Raverot, MD, PhD—Hospices Civils de Lyon
(S) The Role of Lactogens in Signaling the Mother and Fetus (4:15 PM–5:45 PM) Chair: Carmen Clapp, PhD—Universidad Nacional Autonoma de Mexico. Circulating prolactin and prolactin-like proteins are dramatically increased during pregnancy and have key roles in modifying a range of systems which are essential for support of the fetus, preparing the mother for the demands of lactation and programming of offspring. This symposium will include speakers who are dissecting the role prolactin and related proteins of both pituitary and placental origin in key processes which are essential for optimal offspring function. These include the role of these proteins in maternal behavior and altered metabolism the differential roles of each of the various placental lactogens and how placental lactogens mediate fetal programming This symposium will be of interest to basic scientists and clinicians with interests in the importance of maternal physiology in the health of offspring.
Prolactin in Pregnancy and How It Affects Maternal Metabolism and Behavior David R. Grattan, PhD—University of Otago
Epigenetics in the Placenta and Regulation of Placental Lactogens Rosalind M. John, PhD—Cardiff University
Maternal Obesity and Human Placental Lactogen Gene Chromosomal Architecture and Expression Peter A. Cattini, PhD—University of Manitoba
(S) Neuroendocrine Regulation in PCOS (9:15 AM–10:45 AM) Chair: Daniel J. Bernard, PhD—McGill University Polycystic ovary syndrome (PCOS) is a major endocrine disorder affecting women of reproductive age globally. This session will address neuro-endocrine aspects of PCOS and advances in PCOS animal models.
Prepubertal Neuronal Networks in PCOS Suzanne M. Moenter, PhD—University of Michigan
In Vivo LH Pulses and Brain Gene Expression in a Letrozole PCOS Mouse Model Alexander S. Kauffman, PhD—University of California San Diego
Androgen and Progesterone Regulation of LH Secretion in PCOS Women Christopher R. McCartney, MD—University of Virginia School of Medicine
(S) Shining Light: Seasonal Animals Translate Light Cues into Hormone or Metabolic Signals (4:00 PM–5:30 PM) Chair: Paul Roussel Le Tissier, PhD—University of Edinburgh Seasonal animals have dramatic shifts in many aspects of physiology, from reproduction to metabolism and herbal regulation. The mechanisms underlying these physiological changes are also likely to apply to non-seasonal animals, such as humans, and provide targets for therapeutic intervention. This symposium will describe the mechanisms underlying the translation of light cues to season changes at the level of the pituitary and hypothalamus, the signaling pathways which mediate peripheral effects on metabolism and the hypothalamic changes which mediate changes in metabolism and the state of torpor. This symposium will appeal to those interested in the basic understanding of hypothalamic regulation of a number of endocrine axes, as well as showing how basic animal research can impact on identifying targets for clinical therapy.
Timing Annual Cycles in the Pituitary Andrew S. I. Loudon, PhD—University of Manchester
Actions of FGF21 in Metabolism and Appetite Francis J. Ebling, PhD—University of Nottingham
Pituitary Angiogenic Mechanisms Underlie Seasonal Adaptation to a Changing Environment Domingo J. Tortonese, DVM, PhD, DVSc—Faculty of Health Sciences, University of Bristol
(S) Pituitary Hormone Pulse Generation: Is the Hypothalamus the Driver or the Facilitator? (9:15 AM–10:45 AM) Chair: Tatiana Fiordelisio, PhD—Facultad de Ciencias, UNAM Pulsatility is an important feature of endocrine systems, in particular those of the hypothalamic-pituitary tissue axes. This symposium will explore the generation of pulsatility at all three levels with the generation pulses in hypothalamic neurons, in pituitary cells and in that of a target tissue, the adrenal gland. The symposium will include recent studies showing how hypothalamic pulses of GnRH are generated (Jenny Clarkson, Otago, New Zealand), the important role of pituitary cell organization in GH pulse generation (Tatiana Fiordellsio, Mexico City) and the generation of pulsatile glucocorticoid output from the adrenal gland which is autonomous of patterned hypothalamic input (Francesca Spiga, Bristo, UK) and its importance for stress axis function. Each of these describe a shift in our understanding of the interactions of neuroendocrine systems, with important implications for future basic and clinical science studies.
GNRH Pulse Generation Jenny Clarkson, PhD—University of Otago
Pituitary Generation of Hormone Pulses Patrice E. Mollard, PhD—CNRS - INSERM
Importance of ACTH Pulses for Adrenal Function Francesca Spiga, PhD—University of Bristol
President's Announcements and Awards Susan J. Mandel, MD, MPH—Perelman School of Medicine, University of Pennsylvania
Senescent Cells as Targets in Treatment of Metabolic and Cardiovascular Disease Jan M. van Deursen, PhD—Mayo Clinic
Targeting Cellular Senescence in Age-Related Osteoporosis and Frailty Sundeep Khosla, MD—Mayo Clinic College of Medicine
(S) The Good, the Bad, and the Ugly: Senescence in Pituitary Tumors (4:15 PM–5:45 PM) Chair: Shlomo Melmed, MD—Cedars-Sinai Medical Center Recent research has brought about a better understanding of the senescent cell state and its roles in disease and ageing. Senescence in tumors can not only prevent but also promote growth and underlie mechanisms of pathogenesis. This session gives an overview of senescence, its functions, new drug discovery and presents both aspects of senescence in the pathogenesis of pituitary tumors.
Regulation of Senescence in Benign Adenoma Eduardo Arzt, PhD—CONICET and University of Buenos Aires
Tumor-Promoting Effects of Senescent Cells in Pituitary Tumors Juan P. Martinez-Barbera, PhD—University College London
Senescence and Drug Discovery Jesus Gil, PhD—MRC London Institute of Medical Sciences