Neuroendocrinology at ENDO 2019


Our popular Basic Science Pathways are back and have been enhanced to ensure your meeting experience focuses in on the topic area you need. These special “meeting within a meeting” tracks integrate focused discussions, poster sessions, and networking opportunities providing you with an ideal way to surround yourself with the latest research. View the Neuroendocrinology Pathway below and add to your meeting itinerary.

Each track will offer electronic poster previews to help facilitate the viewing of the top scoring abstracts within each topic and receptions to be held at the end of each program.

Plenary(PL) | Session(S) | Educational(E) | Oral Abstracts(O) | Poster Sessions(P) | Reception(R)

Thursday, March 21, 2019

(S) Pan American Neuroendocrine Society Meeting 2019

Our inaugural PANS annual meeting will be held as a satellite meeting of ENDO 2019 in New Orleans. We are excited to partner with the Endocrine Society to host a meeting featuring presentations by leading neuroendocrinologists, and at which neuroendocrine researchers and trainees can share their newest and most exciting findings. PANS2019 will take place March 21-22, 2019, immediately before ENDO 2019. We encourage everyone to enjoy the dual networking activities by attending both of these world-class meetings. Symposia at PANS2019 will focus on four integrated topics that cross traditional neuroendocrine boundaries, including: epigenetic regulation of endocrine signaling; functional investigation of neuroendocrine circuits; circadian and metabolic control of neuroendocrine function; and neuroinflammation and neural injury in neuroendocrine states. Our keynote speaker will be Dr. Margaret M. McCarthy, world-renowned behavioral neuroendocrinologist. Without a doubt, this will be the event of the year for neuroendocrinologists, and we invite all to attend. Hope to see you in New Orleans in March 2019!

Additional registration required for this session.

Saturday, March 23, 2019

Basic Science Pathways

(S) Patterns of Cortisol Secretion: Do We Blame Parents, Genes, or Diet? (9:45 AM–11:15 AM)
Hershel Raff, PhD—Medical College of Wisconsin
This session will examine the control of the HPA axis focusing on early development, circadian rhythms, and the impact of diet using a number of different experimental models.

  • Fetal Programming of the HPA Axis
    Rebecca M. Reynolds, MD, PhD—University of Edinburgh
  • How Stress Systems Interact with Circadian Rhythms
    Robert L. Spencer, PhD—University of Colorado Boulder
  • Impact of Diet on the HPA Axis
    Yvonne M. Ulrich-Lai, PhD—University of Cincinnati

  • (S) Management of Aggressive Pituitary Lesions (4:15 PM–5:45 PM)
    Chair: Vera Popovic-Brkic, MD, PhD—Medical Faculty University of Belgrade
    This session will focus on recent advances in understanding the pathology, treatment effectiveness, and management of aggressive pituitary tumors and carcinomas.

    • Aggressive Pituitary Tumors and Carcinomas: Two Sides of the Same Coin?
      Jacqueline Trouillas MD, PhD—University of Lyon
    • Treatment of Aggressive Pituitary Tumors and Carcinomas
      Ann I. McCormack, MD—St. Vincent's Hospital
    • Molecular Underpinnings of the Aggressive Pituitary Tumor
      Gerald Raverot, MD, PhD—Hospices Civils de Lyon

    (S) The Role of Lactogens in Signaling the Mother and Fetus (4:15 PM–5:45 PM)
    Chair: Carmen Clapp, PhD—Universidad Nacional Autonoma de Mexico.
    Circulating prolactin and prolactin-like proteins are dramatically increased during pregnancy and have key roles in modifying a range of systems which are essential for support of the fetus, preparing the mother for the demands of lactation and programming of offspring. This symposium will include speakers who are dissecting the role prolactin and related proteins of both pituitary and placental origin in key processes which are essential for optimal offspring function. These include the role of these proteins in maternal behavior and altered metabolism the differential roles of each of the various placental lactogens and how placental lactogens mediate fetal programming This symposium will be of interest to basic scientists and clinicians with interests in the importance of maternal physiology in the health of offspring.

    • Prolactin in Pregnancy and How It Affects Maternal Metabolism and Behavior
      David R. Grattan, PhD—University of Otago
    • Epigenetics in the Placenta and Regulation of Placental Lactogens
      Rosalind M. John, PhD—Cardiff University
    • Maternal Obesity and Human Placental Lactogen Gene Chromosomal Architecture and Expression
      Peter A. Cattini, PhD—University of Manitoba

    Sunday, March 24, 2019

    (E) Meet-the-Scientist: CRISPR, RNAi, and shRNA Screens (9:15 AM–10:00 AM)
    A discussion with Christopher K. Glass, MD, PhD—University of California San Diego

    (S) Neuroendocrine Regulation in PCOS (9:15 AM–10:45 AM)
    Chair: Daniel J. Bernard, PhD—McGill University
    Polycystic ovary syndrome (PCOS) is a major endocrine disorder affecting women of reproductive age globally. This session will address neuro-endocrine aspects of PCOS and advances in PCOS animal models.

    • Prepubertal Neuronal Networks in PCOS
      Suzanne M. Moenter, PhD—University of Michigan
    • In Vivo LH Pulses and Brain Gene Expression in a Letrozole PCOS Mouse Model
      Alexander S. Kauffman, PhD—University of California San Diego
    • Androgen and Progesterone Regulation of LH Secretion in PCOS Women
      Christopher R. McCartney, MD—University of Virginia School of Medicine

    (S) Shining Light: Seasonal Animals Translate Light Cues into Hormone or Metabolic Signals (4:00 PM–5:30 PM)
    Chair: Paul Roussel Le Tissier, PhD—University of Edinburgh
    Seasonal animals have dramatic shifts in many aspects of physiology, from reproduction to metabolism and herbal regulation. The mechanisms underlying these physiological changes are also likely to apply to non-seasonal animals, such as humans, and provide targets for therapeutic intervention. This symposium will describe the mechanisms underlying the translation of light cues to season changes at the level of the pituitary and hypothalamus, the signaling pathways which mediate peripheral effects on metabolism and the hypothalamic changes which mediate changes in metabolism and the state of torpor. This symposium will appeal to those interested in the basic understanding of hypothalamic regulation of a number of endocrine axes, as well as showing how basic animal research can impact on identifying targets for clinical therapy.

    • Timing Annual Cycles in the Pituitary
      Andrew S. I. Loudon, PhD—University of Manchester
    • Actions of FGF21 in Metabolism and Appetite
      Francis J. Ebling, PhD—University of Nottingham
    • Pituitary Angiogenic Mechanisms Underlie Seasonal Adaptation to a Changing Environment
      Domingo J. Tortonese, DVM, PhD, DVSc—Faculty of Health Sciences, University of Bristol

    Monday, March 25, 2019

    (PL) Utilizing Big Data in Science and Clinical Care (8:00 AM–9:00 AM)

    • President's Announcements and Awards
      Susan J. Mandel, MD, MPH—Perelman School of Medicine, University of Pennsylvania
    • Accelerating Science through Technology and Collaboration
      Cori Bargmann, PhD—Rockefeller University
    • The Impact of Big Data on Healthcare
      Robert M. Califf, MD—Duke University School of Medicine

    (E) Meet-the-Scientist: Big Data and Bioinformatics for Biologists (9:15 AM–10:00 AM)
    A discussion with Debyani Chakravarty, PhD—Memorial Sloan Kettering Cancer Center.

    (S) Pituitary Hormone Pulse Generation: Is the Hypothalamus the Driver or the Facilitator? (9:15 AM–10:45 AM)
    Chair: Tatiana Fiordelisio, PhD—Facultad de Ciencias, UNAM
    Pulsatility is an important feature of endocrine systems, in particular those of the hypothalamic-pituitary tissue axes. This symposium will explore the generation of pulsatility at all three levels with the generation pulses in hypothalamic neurons, in pituitary cells and in that of a target tissue, the adrenal gland. The symposium will include recent studies showing how hypothalamic pulses of GnRH are generated (Jenny Clarkson, Otago, New Zealand), the important role of pituitary cell organization in GH pulse generation (Tatiana Fiordellsio, Mexico City) and the generation of pulsatile glucocorticoid output from the adrenal gland which is autonomous of patterned hypothalamic input (Francesca Spiga, Bristo, UK) and its importance for stress axis function. Each of these describe a shift in our understanding of the interactions of neuroendocrine systems, with important implications for future basic and clinical science studies.

    • GNRH Pulse Generation
      Jenny Clarkson, PhD—University of Otago
    • Pituitary Generation of Hormone Pulses
      Patrice E. Mollard, PhD—CNRS - INSERM
    • Importance of ACTH Pulses for Adrenal Function
      Francesca Spiga, PhD—University of Bristol

    (O) Oral Abstracts: Neuroendocrinology (11:00 AM–12:30 PM)
    Learn and engage with the authors of the top submitted abstracts.

    (P) Poster Session: Neuroendocrinology (1:00 PM–3:00 PM)
    View and discuss submitted posters on neuroendocrinology.

    (E) Meet-the-Scientist: Single-Cell Sequencing (2:00 PM–2:45 PM)
    A discussion with Aviv Regev, PhD—Broad Institute

    (PL) Targeting Senescent Cells in Aging and Disease (3:00 PM–4:00 PM)

    • President's Announcements and Awards
      Susan J. Mandel, MD, MPH—Perelman School of Medicine, University of Pennsylvania
    • Senescent Cells as Targets in Treatment of Metabolic and Cardiovascular Disease
      Jan M. van Deursen, PhD—Mayo Clinic
    • Targeting Cellular Senescence in Age-Related Osteoporosis and Frailty
      Sundeep Khosla, MD—Mayo Clinic College of Medicine

    (S) The Good, the Bad, and the Ugly: Senescence in Pituitary Tumors (4:15 PM–5:45 PM)
    Chair: Shlomo Melmed, MD—Cedars-Sinai Medical Center
    Recent research has brought about a better understanding of the senescent cell state and its roles in disease and ageing. Senescence in tumors can not only prevent but also promote growth and underlie mechanisms of pathogenesis. This session gives an overview of senescence, its functions, new drug discovery and presents both aspects of senescence in the pathogenesis of pituitary tumors.

    • Regulation of Senescence in Benign Adenoma
      Eduardo Arzt, PhD—CONICET and University of Buenos Aires
    • Tumor-Promoting Effects of Senescent Cells in Pituitary Tumors
      Juan P. Martinez-Barbera, PhD—University College London
    • Senescence and Drug Discovery
      Jesus Gil, PhD—MRC London Institute of Medical Sciences

    (R) Networking Reception: Neuroendocrinology (5:45 PM–7:00 PM)
    Network with your colleagues and leaders in the field. Click here to RSVP.

    Please see your other Basic Science Pathways: Reproductive Endocrinology and Nuclear Receptors and Gene Regulation