Nuclear Receptors and Gene Regulation at ENDO 2019


Our popular Basic Science Pathways are back and have been enhanced to ensure your meeting experience focuses in on the topic area you need. These special “meeting within a meeting” tracks integrate focused discussions, poster sessions, and networking opportunities providing you with an ideal way to surround yourself with the latest research. View the Nuclear Receptors and Gene Regulation Pathway below and add to your meeting itinerary

Plenary (PL) | Session (S) | Educational (E) | Oral Abstracts (O) | Poster Session (P) | Reception (R)

Saturday, March 23, 2019

(S) Cardiorenal Impact of Dysregulated RAAS (9:45 AM–11:15 AM)
Chair: Peter J. Fuller, AM, MBBS, PhD, FRACP—Hudson Institute of Medical Research
This session will have an interdisciplinary discussion of the pathophysiological outcomes of RAAS dysregulation. Both renal and cardiovascular disease mechanisms will be discussed.

  • The Role of the RAAS in Defining Sex Differences in Hypertension
    Jane F. Reckelhoff, PhD—University of Mississippi Medical Center
  • Biological Sex Modulates Renovascular Responses to Angiotensin II
    Jose R. Romero, PhD—Harvard Medical School
  • Effects of Aldosterone on the Proteome of the Distal Nephron
    Robert A. Fenton, PhD—Aarhus University
  • Urinary Exosome Sodium Transporters in Hyperaldosteronism and Hypercortisolism
    Ewout J. Hoorn, MD, PhD—Erasmus Medical Center

Basic Science Pathways

(S) Genomic Imprinting and Endocrine Dysfunction (9:45 AM–11:15 AM)
Chair: Marika Charalambous, PhD—King's College London
Genomic imprinting is an epigenetic phenomenon leading to monoallelic expression of nearby genes in a parent-of-origin manner. Since it is well known that imprinted genes encode some of the major genetic modulators of placentation and intrauterine growth, studying the mechanisms by which they regulate molecular pathways can be used to provide fundamental insights into these processes. More recently data from human imprinted disorders and murine models have revealed a wealth of endocrine pathways that are modulated by imprinted genes across the lifecourse, including roles in Adipose Tissue, Appetite and Obesity, Glucose Metabolism, Development, Neuroendocrine and Pituitary Biology, Pediatric and Reproductive Endocrinology. The session will review the action of this class of genes in the context of their action on a wide variety of endocrine processes and diseases.

  • Mechanisms of Genomic Imprinting
    Rebecca A. Simmons, MD—Perelman School of Medicine University Pennsylvania
  • Disorders of Growth Caused by Genomic Imprinting
    Karen I. Temple, MD, MB-ChB, FRCP—University of Southampton
  • Causes and Consequences of Multi-Locus Imprinting Disturbances
    Agnes Linglart, MD, PhD—APHP Bicetre Paris Sud

(S) Transcriptional and Epigenetic Control of Metabolic Homeostasis (9:45 AM–11:15 AM)
Chair: Daniel E. Frigo, PhD—UT MD Anderson Cancer Center
This session focuses on the mechanisms and signaling relationships between nuclear receptors, coregulators, and metabolic pathways. Speakers will describe the roles of these signaling pathways in normal tissue homeostasis and their deregulation in disease.

  • Metabolic Control of Breast Cancer by Steroid Receptor Coactivator-3
    Subhamoy Dasgupta, PhD—Roswell Park Comprehensive Cancer Center
  • DNMT3A as an Epigenetic Mediator of Insulin Resistance
    Sona Kang, PhD—University of California Berkeley
  • Control of Metabolic Homeostasis and Epigenetics by ERR Alpha
    Vincent Giguere, PhD, FRSC—McGill University

(S) Vitamin D and Health Across the Lifespan (4:15 PM–5:45 PM)
Chair: John S. Adams, MD—UCLA Department of Orthopaedic Surgery
There is compelling data about antenatal and early post-natal effects of vitamin D on placental function, fetal outcomes, and on autoimmunity. This session will address non-classical effects of vitamin D. The first two speakers, one basic, one clinical, will address these early effects on placenta and fetal outcomes and the last would give an overall perspective.

  • Maternal Vitamin D and Neonatal Immunity
    Catherine M. Hawrylowicz, PhD—Kings College London
  • The Influence of Vitamin D on Autoimmune Disease Outcomes in the VDAART Study
    Scott T. Weiss, MD, MS—Brigham and Women's Hospital
  • Vitamin D and Autoimmunity
    Chantal Mathieu, MD, PhD—KU Leuven

(S) Structural and Chemical Biology of Steroid Receptors and Coregulators (4:15 PM–5:45 PM)
Chair: Charlotte Lynne Bevan, PhD—Imperial College London
This session focuses on the structural and chemical biology of steroid receptors and coregulators. Attendees will learn how biophysical and computational approaches to understanding the structures of steroid receptors and coregulators have revealed opportunities for the development of small molecules that target key functions required for transcriptional activation.

  • Structure-Activity Relationships in VDR-Ligand Interactions
    Natacha Rochel, PhD—IGBMC
  • Epigenetic Targeting of Triple Negative Breast Cancer
    Ruth A. Keri, PhD—Case Western Research University School of Medicine
  • Therapeutic Targeting Novel Functional Domains of the AR
    Paul S. Rennie, PhD, FCAHS—Vancouver Prostate Centre/UBC

Sunday, March 24, 2019

(PL) Novel Therapeutic Targets in Metabolic Disease and Cancer (8:00 AM–9:00 AM)

  • President's Announcements and Awards
    Susan J. Mandel, MD, MPH—Perelman School of Medicine, University of Pennsylvania
  • New Pathways in Cellular and Systemic Lipid Metabolism
    Peter J. Tontonoz, MD, PhD—University of California-Los Angeles
  • Nuclear Receptor Signaling in Breast and Prostate Cancer
    Myles A. Brown, MD—Dana-Farber Cancer Institute

(E) Meet-the-Scientist: CRISPR, RNAi, and shRNA Screens
A discussion with Christopher K. Glass, MD, PhD—University of California - San Diego

(S) Mechanisms of Growth and Development (9:15 AM–10:45 AM)
Chair: Allen W. Root, MD—Johns Hopkins All Children's Hospital
This session will review a myriad of factors, beginning in utero that are responsible for normal and abnormal childhood growth and development.

  • Discovery and Development of a Growth Hormone Receptor Antagonist
    John J. Kopchick, PhD—Ohio University, Edison Biotechnology Institute
  • Genetics of Overgrowth
    Jeffrey Baron, MD—NIH, Bethesda, MD
  • Central Obesity, Faster Maturation, and "PCOS" Development in Girls
    Francis E. de Zegher, MD, PhD—University of Leuven

(S) Molecular Determinants of Nuclear Receptor Function (9:15 AM–10:45 AM)
Chair: Michael Garabedian, PhD—NYU School of Medicine
Nuclear receptors are the largest family of transcription factors that contribute to every aspect of physiology and pathology in mammals. This session will focus on advances in structural analyses of DNA/nuclear receptor complexes, the contribution of ligand binding to these interactions, and the role of chromatin to receptor function.

  • Phospholipid Ligand-Activated Nuclear Receptors
    Holly A. Ingraham, PhD—University of California San Francisco
  • Structural Studies of DNA: Nuclear Receptor Interactions
    Eric Ortlund, PhD—Emory University School of Medicine
  • Posttranslational Modification of Steroid Receptors
    Elaine T. Alarid, PhD—University of Wisconsin - Madison
  • Structural Analysis of Nuclear Receptor Corepressor Complexes
    John W. Schwabe, PhD, ScD—University of Leicester

(S) Novel Pathways of Thyroid Hormone Signaling and Metabolism (9:15 AM–10:45 AM)
Chair: Yan-Yun Liu, PhD—University of California School of Medicine - VA Healthcare System
The session will highlight recent developments and our current understanding of thyroid hormone transport and action into different target tissues. The first talk points out relevant differences between rodent models and humans. The second talk will provide novel mechanistic insights into the phenotypic spectrum associated with deficiency of SBP2, which is essential for normal deiodinase and selenoprotein function. The last talk will focus on novel insights into noncanonical thyroid hormone action - it is real!

  • Who Transports Whom and Where? An Update on Thyroid Hormone Transporters in Mice and Humans
    Heike Heuer, PhD—University Hospital Essen, Clinic for Endocrinology
  • SBP2 Deficiency: Complex Endocrine Phenotypes in the Thyroid and Beyond
    Alexandra M. Dumitrescu, MD, PhD—University of Chicago
  • Noncanonical Thyroid Hormone Signaling In Vivo
    Lars C. Moeller, MD—University of Duisburg-Essen

(O) Oral Abstracts: Nuclear Receptors and Gene Regulation (11:00 AM–12:30 PM)
Learn and engage with the authors of the top submitted abstracts.

(P) Poster Session: Nuclear Receptors and Gene Regulation (1:00 PM–3:00 PM)
View and discuss submitted posters on nuclear receptors and gene regulation.

(S) New Technologies: Cellular Organization Across Time and Space (1:45 PM–2:45 PM)
Chair: Myles Brown, MD—Dana-Farber Cancer Institute
New concepts and methodologies for understanding cell organization and structure will be presented.

  • Receptor Mobility, Chromatin Tracking, and Transcriptional Bursting in Live Cells
    Gordon L. Hager, PhD—National Institutes of Health
  • Phase Separation in the Nucleus
    Bryan A. Gibson, PhD – UT Southwestern Medical Center
  • Using Cryo-Electron Microscopy to Study Nuclear Receptor Transcription Complexes
    Bert W. O'Malley, MD—Baylor College of Medicine

(PL) Hormone Science to Health: The Endocrine Society Goes to the National Academy of Sciences (2:45 PM–3:45 PM)

  • Nature and Nurture of Tissue Resident Macrophages in Health and Disease
    Christopher K. Glass, MD, PhD—University of California - San Diego
  • Nuclear Receptors, Endocrinology, and Metabolism
    Mitchell A. Lazar, MD, PhD—University of Pennsylvania
  • Novel Therapeutic Targets in Diabetes and Metabolic Diseases
    Barbara B. Kahn, MS, MD—Beth Israel Deaconess Medical Center

(S) Hormone Signaling in the Islet: New Concepts (4:00 PM–5:30 PM)
Chair: Laura C. Alonso, MD—University of Massachusetts Medical School
This session will discuss intra-islet signaling that can affect beta-cell maturation and function.

  • Islet Interleukin Signaling in Regulation of the Beta-Cell
    Prof. Marc Y. Donath—Universitaetsspital Basel
  • Paracrine Regulation of Beta-Cell Maturation and Differentiation
    Mark O. Huising, PhD—University of California - Davis
  • Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point
    Alejandro Caicedo, PhD—University of Miami Miller School of Medicine

(S) New Mechanisms of Steroid Receptor Activation in Hormone-Dependent Cancers (4:00 PM–5:30 PM)
Chair: Diane M. Robins, PhD—University of Michigan Medical School
This session focuses on newly-discovered mechanisms underlying the activation of estrogen receptor (ER) in breast cancer and androgen receptor (AR) in prostate cancer, with emphasis on endocrine therapy-resistant disease. Attendees will be able to discuss mechanisms of steroid receptor activation in hormone-dependent cancers.

  • Genomic Alterations Activating AR in Prostate Cancer
    Matthew Freedman, MD—Dana Farber Cancer Institute
  • Activation of ER in Breast Cancer
    Steffi Oesterreich, PhD—University of Pittsburgh
  • Development of New Anti-Estrogen and Other Therapies Targeting Treatment-Resistant Breast Cancer
    Benita S. Katzenellenbogen, PhD—University of Illinois - Urbana
  • Effects of Deregulated AR on Chromatin
    Fahri Saatcioglu, PhD—University of Oslo

(R) Networking Reception: Nuclear Receptors and Gene Regulation (5:30 PM–7:00 PM)
Network with your colleagues and leaders in the field. Click here to RSVP.

Monday, March 25, 2019

(E) Meet-the-Scientist: Big Data and Bioinformatics for Biologists ( 9:15 AM–10:00 AM)
A discussion with Debyani Chakravarty, PhD—Memorial Sloan Kettering Cancer Center

(S) Regulation of Metabolic Circuits in the Muscle (9:15 AM–10:45 AM)
Chair: Laszlo Nagy, MD, PhD—Sanford Burnham Prebys Medical Discovery Institute
Skeletal muscle critically contributes to energy homeostasis and glucose and lipid metabolism. Physical exercise generally improves insulin sensitivity and, reciprocally, poor physical fitness is a risk factor for insulin resistance and type 2 diabetes. Like other metabolic tissues, skeletal muscle is the key site of action for several nuclear receptors—peroxisome proliferator-activated receptors (PPARs) and estrogen-related receptors (ERRs) in particular. Understanding how they function should yield approaches to targeting these receptors for improving metabolic health, especially in conditions of chronic muscle pathologies, or age-related or post-traumatic degeneration.

  • Muscle-Derived Metabolites That Impact Nutrient Homeostasis
    Zoltan Arany, MD, PhD—University of Pennsylvania
  • Estrogen-Related Receptor Signaling in Skeletal Muscle Function
    Anastasia Kralli, PhD—Johns Hopkins Medical Institute
  • Exercise is a Key Regulator of Metabolic Circuits in Muscle
    Bret Goodpaster, PhD—Translational Research Institute for Metabolism and Diabetes, Florida Hospital
  • Transcriptional Regulation of Skeletal Muscle Function
    Vihang A. Narkar, PhD—University of Texas McGovern Medical School

(S) Understanding Metabolic Regulation in Hormone-Related Cancers to Identify Vulnerabilities for Treatment (9:15 AM–10:45 AM)
Chair: Isabel R. Schlaepfer, PhD—University of Colorado Anschutz Medical Campus
Nuclear receptors regulate central metabolism in breast and prostate cancer. This session will focus on the mechanisms by which the metabolic needs of cancer cells are met by nuclear receptor action, and also explore how metabolic pathways regulate the action of nuclear receptors.

  • Warburg Effect and Glutamine Metabolism in Cancer
    Jason Locasale, PhD—Duke University
  • Regulation of Prostate Cancer Metabolism
    Nancy L. Weigel, PhD—Baylor College of Medicine
  • Therapeutic Targeting of Fatty Acid Metabolism in Prostate Cancer
    Massimo Loda, MD—Dana-Farber Cancer Institute

(S) Meet-the-Scientist: Single-Cell Sequencing (2:00 PM–2:45 PM)
A discussion with Aviv Regev, PhD—Broad Inst, Cambridge, MA

(S) Understanding Nuclear Receptor Function through "Omics" (4:15 PM–5:45 PM)
Chair: Karolien De Bosscher, PhD—VIB Center for Medical Biotechnology and University of Ghent
Recent years have seen paradigm-shifting insights into nuclear receptor-driven transcription programs that emerged through genome-wide approaches. There has been a tremendous effort to integrate transcriptomic studies with genome-wide factor binding analyses, identification of active enhancers, higher order chromatin interactions, and, most recently, single-cell transcriptomics. This session will illustrate how a combination of these approaches yields not only a global view of gene expression programs that occur in response to developmental, pharmacological, and environmental triggers or in disease, but identify "novel" rare populations of cells that are responsible for precise biological processes.

  • Integrative Genomics and Computational Biology to Study Nuclear Receptor Function
    Timothy Reddy, PhD—Duke University GCB
  • Studying Male Sex Determination and Cell Lineage Commitment Using Single-Cell RNA-Seq
    Serge Nef, PhD—University of Geneva
  • Genome-Wide Analysis of Macrophage Gene Expression by LXRa and Hyperglycemia
    Michael Garabedian, PhD—NYU School of Medicine
  • "Omics" Approaches to Study Nuclear Receptor Crosstalk Mechanisms
    Karolien De Bosscher, PhD—UGent-VIB

Tuesday, March 26, 2019

(S) Regulation of Metabolism by Nuclear Receptors (8:00 AM–9:30 AM)
Chair: Mitchell A. Lazar, MD, PhD—University of Pennsylvania
Nuclear receptors are essential regulators of every aspect of metabolic control whose disrupted function leads to insulin resistance, type II diabetes and other pathologies. This session will focus on different actions of nuclear receptors that impact glucose and lipid metabolism.

  • LXR Phosphorylation in Non-Alcoholic Fatty Liver Disease
    Ines Pineda Torra, PhD—University College London
  • Pregnane X Receptor Metabolic Program
    Taosheng Chen, PhD—St. Jude Children's Research Hospital
  • Development of Glucocorticoids with Beneficial Effects on Mitochondrial Health
    Nelson E. Bruno, MD, PhD—TSRI
  • The Microbiome in Metabolic Homeostasis
    Frank J. Gonzalez, PhD—Center for Cancer Research, Bethesda

(S) Nuclear Receptor Control of Immunity (11:45 AM–1:15 PM)
Chair: Christopher K. Glass, MD, PhD—University of California San Diego
Nuclear receptors have emerged as important regulators of immune cell function. This session will focus on nuclear receptor biology in different immune cell subsets in health and disease.

  • Sex Hormone Receptors in Neuroinflammation
    Kaoru Saijo, MD, PhD—University of California Berkeley
  • Orphan Nuclear Receptor Ligands in T-Cells
    Laura A. Solt, PhD—The Scripps Research Institute
  • RXR/PPAR-γ Dendritic Cells and Macrophages
    Laszlo Nagy, MD, PhD—Sanford Burnham Prebys Medical Discovery Institute

Please see your other Basic Science Pathways: Reproductive Endocrinology and Neuroendocrinology