Nuclear Receptors and Gene Regulation at ENDO 2019
Our popular Basic Science Pathways are back and have been enhanced to ensure your meeting experience focuses in on the topic area you need. These special “meeting within a meeting” tracks integrate focused discussions, poster sessions, and networking opportunities providing you with an ideal way to surround yourself with the latest research. View the Nuclear Receptors and Gene Regulation Pathway below and add to your meeting itinerary
(S) Cardiorenal Impact of Dysregulated RAAS (9:45 AM–11:15 AM) Chair: Peter J. Fuller, AM, MBBS, PhD, FRACP—Hudson Institute of Medical Research This session will have an interdisciplinary discussion of the pathophysiological outcomes of RAAS dysregulation. Both renal and cardiovascular disease mechanisms will be discussed.
The Role of the RAAS in Defining Sex Differences in Hypertension Jane F. Reckelhoff, PhD—University of Mississippi Medical Center
Biological Sex Modulates Renovascular Responses to Angiotensin II Jose R. Romero, PhD—Harvard Medical School
Effects of Aldosterone on the Proteome of the Distal Nephron Robert A. Fenton, PhD—Aarhus University
Urinary Exosome Sodium Transporters in Hyperaldosteronism and Hypercortisolism Ewout J. Hoorn, MD, PhD—Erasmus Medical Center
(S) Genomic Imprinting and Endocrine Dysfunction (9:45 AM–11:15 AM) Chair: Marika Charalambous, PhD—King's College London Genomic imprinting is an epigenetic phenomenon leading to monoallelic expression of nearby genes in a parent-of-origin manner. Since it is well known that imprinted genes encode some of the major genetic modulators of placentation and intrauterine growth, studying the mechanisms by which they regulate molecular pathways can be used to provide fundamental insights into these processes. More recently data from human imprinted disorders and murine models have revealed a wealth of endocrine pathways that are modulated by imprinted genes across the lifecourse, including roles in Adipose Tissue, Appetite and Obesity, Glucose Metabolism, Development, Neuroendocrine and Pituitary Biology, Pediatric and Reproductive Endocrinology. The session will review the action of this class of genes in the context of their action on a wide variety of endocrine processes and diseases.
Mechanisms of Genomic Imprinting Rebecca A. Simmons, MD—Perelman School of Medicine University Pennsylvania
Disorders of Growth Caused by Genomic Imprinting Karen I. Temple, MD, MB-ChB, FRCP—University of Southampton
Causes and Consequences of Multi-Locus Imprinting Disturbances Agnes Linglart, MD, PhD—APHP Bicetre Paris Sud
(S) Transcriptional and Epigenetic Control of Metabolic Homeostasis (9:45 AM–11:15 AM) Chair: Daniel E. Frigo, PhD—UT MD Anderson Cancer Center This session focuses on the mechanisms and signaling relationships between nuclear receptors, coregulators, and metabolic pathways. Speakers will describe the roles of these signaling pathways in normal tissue homeostasis and their deregulation in disease.
Metabolic Control of Breast Cancer by Steroid Receptor Coactivator-3 Subhamoy Dasgupta, PhD—Roswell Park Comprehensive Cancer Center
DNMT3A as an Epigenetic Mediator of Insulin Resistance Sona Kang, PhD—University of California Berkeley
Control of Metabolic Homeostasis and Epigenetics by ERR Alpha Vincent Giguere, PhD, FRSC—McGill University
(S) Vitamin D and Health Across the Lifespan (4:15 PM–5:45 PM) Chair: John S. Adams, MD—UCLA Department of Orthopaedic Surgery There is compelling data about antenatal and early post-natal effects of vitamin D on placental function, fetal outcomes, and on autoimmunity. This session will address non-classical effects of vitamin D. The first two speakers, one basic, one clinical, will address these early effects on placenta and fetal outcomes and the last would give an overall perspective.
Maternal Vitamin D and Neonatal Immunity Catherine M. Hawrylowicz, PhD—Kings College London
The Influence of Vitamin D on Autoimmune Disease Outcomes in the VDAART Study Scott T. Weiss, MD, MS—Brigham and Women's Hospital
Vitamin D and Autoimmunity Chantal Mathieu, MD, PhD—KU Leuven
(S) Structural and Chemical Biology of Steroid Receptors and Coregulators (4:15 PM–5:45 PM) Chair: Charlotte Lynne Bevan, PhD—Imperial College London This session focuses on the structural and chemical biology of steroid receptors and coregulators. Attendees will learn how biophysical and computational approaches to understanding the structures of steroid receptors and coregulators have revealed opportunities for the development of small molecules that target key functions required for transcriptional activation.
Structure-Activity Relationships in VDR-Ligand Interactions Natacha Rochel, PhD—IGBMC
Epigenetic Targeting of Triple Negative Breast Cancer Ruth A. Keri, PhD—Case Western Research University School of Medicine
Therapeutic Targeting Novel Functional Domains of the AR Paul S. Rennie, PhD, FCAHS—Vancouver Prostate Centre/UBC
(S) Mechanisms of Growth and Development (9:15 AM–10:45 AM) Chair: Allen W. Root, MD—Johns Hopkins All Children's Hospital This session will review a myriad of factors, beginning in utero that are responsible for normal and abnormal childhood growth and development.
Discovery and Development of a Growth Hormone Receptor Antagonist John J. Kopchick, PhD—Ohio University, Edison Biotechnology Institute
Genetics of Overgrowth Jeffrey Baron, MD—NIH, Bethesda, MD
Central Obesity, Faster Maturation, and "PCOS" Development in Girls Francis E. de Zegher, MD, PhD—University of Leuven
(S) Molecular Determinants of Nuclear Receptor Function (9:15 AM–10:45 AM) Chair: Michael Garabedian, PhD—NYU School of Medicine Nuclear receptors are the largest family of transcription factors that contribute to every aspect of physiology and pathology in mammals. This session will focus on advances in structural analyses of DNA/nuclear receptor complexes, the contribution of ligand binding to these interactions, and the role of chromatin to receptor function.
Phospholipid Ligand-Activated Nuclear Receptors Holly A. Ingraham, PhD—University of California San Francisco
Structural Studies of DNA: Nuclear Receptor Interactions Eric Ortlund, PhD—Emory University School of Medicine
Posttranslational Modification of Steroid Receptors Elaine T. Alarid, PhD—University of Wisconsin - Madison
Structural Analysis of Nuclear Receptor Corepressor Complexes John W. Schwabe, PhD, ScD—University of Leicester
(S) Novel Pathways of Thyroid Hormone Signaling and Metabolism (9:15 AM–10:45 AM) Chair: Yan-Yun Liu, PhD—University of California School of Medicine - VA Healthcare System The session will highlight recent developments and our current understanding of thyroid hormone transport and action into different target tissues. The first talk points out relevant differences between rodent models and humans. The second talk will provide novel mechanistic insights into the phenotypic spectrum associated with deficiency of SBP2, which is essential for normal deiodinase and selenoprotein function. The last talk will focus on novel insights into noncanonical thyroid hormone action - it is real!
Who Transports Whom and Where? An Update on Thyroid Hormone Transporters in Mice and Humans Heike Heuer, PhD—University Hospital Essen, Clinic for Endocrinology
SBP2 Deficiency: Complex Endocrine Phenotypes in the Thyroid and Beyond Alexandra M. Dumitrescu, MD, PhD—University of Chicago
Noncanonical Thyroid Hormone Signaling In Vivo Lars C. Moeller, MD—University of Duisburg-Essen
Islet Interleukin Signaling in Regulation of the Beta-Cell Prof. Marc Y. Donath—Universitaetsspital Basel
Paracrine Regulation of Beta-Cell Maturation and Differentiation Mark O. Huising, PhD—University of California - Davis
Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point Alejandro Caicedo, PhD—University of Miami Miller School of Medicine
(S) New Mechanisms of Steroid Receptor Activation in Hormone-Dependent Cancers (4:00 PM–5:30 PM) Chair: Diane M. Robins, PhD—University of Michigan Medical School This session focuses on newly-discovered mechanisms underlying the activation of estrogen receptor (ER) in breast cancer and androgen receptor (AR) in prostate cancer, with emphasis on endocrine therapy-resistant disease. Attendees will be able to discuss mechanisms of steroid receptor activation in hormone-dependent cancers.
Genomic Alterations Activating AR in Prostate Cancer Matthew Freedman, MD—Dana Farber Cancer Institute
Activation of ER in Breast Cancer Steffi Oesterreich, PhD—University of Pittsburgh
Development of New Anti-Estrogen and Other Therapies Targeting Treatment-Resistant Breast Cancer Benita S. Katzenellenbogen, PhD—University of Illinois - Urbana
Effects of Deregulated AR on Chromatin Fahri Saatcioglu, PhD—University of Oslo
(S) Regulation of Metabolic Circuits in the Muscle (9:15 AM–10:45 AM) Chair: Laszlo Nagy, MD, PhD—Sanford Burnham Prebys Medical Discovery Institute Skeletal muscle critically contributes to energy homeostasis and glucose and lipid metabolism. Physical exercise generally improves insulin sensitivity and, reciprocally, poor physical fitness is a risk factor for insulin resistance and type 2 diabetes. Like other metabolic tissues, skeletal muscle is the key site of action for several nuclear receptors—peroxisome proliferator-activated receptors (PPARs) and estrogen-related receptors (ERRs) in particular. Understanding how they function should yield approaches to targeting these receptors for improving metabolic health, especially in conditions of chronic muscle pathologies, or age-related or post-traumatic degeneration.
Muscle-Derived Metabolites That Impact Nutrient Homeostasis Zoltan Arany, MD, PhD—University of Pennsylvania
Estrogen-Related Receptor Signaling in Skeletal Muscle Function Anastasia Kralli, PhD—Johns Hopkins Medical Institute
Exercise is a Key Regulator of Metabolic Circuits in Muscle Bret Goodpaster, PhD—Translational Research Institute for Metabolism and Diabetes, Florida Hospital
Transcriptional Regulation of Skeletal Muscle Function Vihang A. Narkar, PhD—University of Texas McGovern Medical School
(S) Understanding Nuclear Receptor Function through "Omics" (4:15 PM–5:45 PM) Chair: Karolien De Bosscher, PhD—VIB Center for Medical Biotechnology and University of Ghent Recent years have seen paradigm-shifting insights into nuclear receptor-driven transcription programs that emerged through genome-wide approaches. There has been a tremendous effort to integrate transcriptomic studies with genome-wide factor binding analyses, identification of active enhancers, higher order chromatin interactions, and, most recently, single-cell transcriptomics. This session will illustrate how a combination of these approaches yields not only a global view of gene expression programs that occur in response to developmental, pharmacological, and environmental triggers or in disease, but identify "novel" rare populations of cells that are responsible for precise biological processes.
Integrative Genomics and Computational Biology to Study Nuclear Receptor Function Timothy Reddy, PhD—Duke University GCB
Studying Male Sex Determination and Cell Lineage Commitment Using Single-Cell RNA-Seq Serge Nef, PhD—University of Geneva
Genome-Wide Analysis of Macrophage Gene Expression by LXRa and Hyperglycemia Michael Garabedian, PhD—NYU School of Medicine
"Omics" Approaches to Study Nuclear Receptor Crosstalk Mechanisms Karolien De Bosscher, PhD—UGent-VIB
Tuesday, March 26, 2019
(S) Regulation of Metabolism by Nuclear Receptors (8:00 AM–9:30 AM) Chair: Mitchell A. Lazar, MD, PhD—University of Pennsylvania Nuclear receptors are essential regulators of every aspect of metabolic control whose disrupted function leads to insulin resistance, type II diabetes and other pathologies. This session will focus on different actions of nuclear receptors that impact glucose and lipid metabolism.
LXR Phosphorylation in Non-Alcoholic Fatty Liver Disease Ines Pineda Torra, PhD—University College London
Pregnane X Receptor Metabolic Program Taosheng Chen, PhD—St. Jude Children's Research Hospital
Development of Glucocorticoids with Beneficial Effects on Mitochondrial Health Nelson E. Bruno, MD, PhD—TSRI
The Microbiome in Metabolic Homeostasis Frank J. Gonzalez, PhD—Center for Cancer Research, Bethesda
(S) Nuclear Receptor Control of Immunity (11:45 AM–1:15 PM) Chair: Christopher K. Glass, MD, PhD—University of California San Diego Nuclear receptors have emerged as important regulators of immune cell function. This session will focus on nuclear receptor biology in different immune cell subsets in health and disease.
Sex Hormone Receptors in Neuroinflammation Kaoru Saijo, MD, PhD—University of California Berkeley
Orphan Nuclear Receptor Ligands in T-Cells Laura A. Solt, PhD—The Scripps Research Institute
RXR/PPAR-γ Dendritic Cells and Macrophages Laszlo Nagy, MD, PhD—Sanford Burnham Prebys Medical Discovery Institute