Our popular Basic Science Pathways are back and have been enhanced to ensure your meeting experience focuses in on the topic area you need. These special “meeting within a meeting” tracks integrate focused discussions, poster sessions, and networking opportunities providing you with an ideal way to surround yourself with the latest research. View the Reproductive Endocrinology Pathway below and add to your meeting itinerary.
Each track will offer electronic poster previews to help facilitate the viewing of the top scoring abstracts within each topic and receptions to be held at the end of each program.
Speakers at this one-day, topic-focused meeting, including selected oral presenters from submitted abstracts, will tackle new and emerging understanding of the potential role for intrauterine environment in the reproductive, psychiatric, and metabolic disturbances in offspring of women with polycystic ovary syndrome (PCOS) using human data and relevant animal models. Presentations include:
Implications of Polycystic Ovary Syndrome for Pregnancy and for the Health of Offspring
Intergenerational Associations of Chronic Disease and Polycystic Ovary Syndrome
Polycystic Ovary Syndrome Is Associated with Adverse Mental Health and Neurodevelopmental Outcomes
Does Maternal Androgen Exposure and Diet-Induced Obesity Increase the Susceptibility of Transgenerational Disease?
The meeting will finish with a debate and audience discussion of the motion: "Is maternal metabolic disease the risk factor for intergenerational transmission of PCOS?"
President's Announcements and Awards Susan J. Mandel, MD, MPH—University of Pennsylvania
Repair of Mitochondrial DNA in Embryos Juan Carlos Izpisua Belmonte, PhD—Salk Institute
Genomic Imprinting and Epigenetic Gene Regulation Marisa Bartolomei, PhD—University of Pennsylvania
(S) Vitamin D and Health Across the Lifespan (4:15 PM–5:45 PM) Chair: John S. Adams, MD—UCLA Dept Orthopaedic Surgery. There is compelling data about antenatal and early post-natal effects of vitamin D on placental function, fetal outcomes, and on autoimmunity. This session will address non-classical effects of vitamin D. The first two speakers, one basic, one clinical, will address these early effects on placenta and fetal outcomes and the last would give an overall perspective.
Maternal Vitamin D and Neonatal Immunity Catherine M. Hawrylowicz, PhD—Kings College London
The Influence of Vitamin D on Autoimmune Disease Outcomes in the VDAART Study Scott T. Weiss, MD, MS—Brigham and Women's Hospital
Vitamin D and Autoimmunity Chantal Mathieu, MD, PhD—KU Leuven
Nodal in Embryo Implantation Daniel Dufort, PhD—McGill University
TGF-beta Signaling in Uterine Function and Disease: Insights from Genetically Modified Mouse Models Qinglei Li, PhD—Texas A&M University
Transforming growth factor-ß family and its modulating microRNAs in placental development and uterine spiral artery remodeling Chun Peng, MS, PhD—York University
(S) The Role of Lactogens in Signaling the Mother and Fetus (4:15 PM–5:45 PM) Chair: Carmen Clapp, PhD—Universidad Nacional Autonoma de Mexico. Circulating prolactin and prolactin-like proteins are dramatically increased during pregnancy and have key roles in modifying a range of systems which are essential for support of the fetus, preparing the mother for the demands of lactation and programming of offspring. This symposium will include speakers who are dissecting the role prolactin and related proteins of both pituitary and placental origin in key processes which are essential for optimal offspring function. These include the role of these proteins in maternal behavior and altered metabolism the differential roles of each of the various placental lactogens and how placental lactogens mediate fetal programming. This symposium will be of interest to basic scientists and clinicians with interests in the importance of maternal physiology in the health of offspring.
Prolactin in Pregnancy and How It Affects Maternal Metabolism and Behavior David R. Grattan, PhD—University of Otago
Epigenetics in the Placenta and Regulation of Placental Lactogens Rosalind M. John, PhD—Cardiff University
Maternal Obesity and Human Placental Lactogen Gene Chromosomal Architecture and Expression Peter A. Cattini, PhD—University of Manitoba
(S) Neuroendocrine Regulation in PCOS (9:15 AM–10:45 AM) Chair: Daniel J. Bernard, PhD—McGill University Polycystic ovary syndrome (PCOS) is a major endocrine disorder affecting women of reproductive age globally. This session will address neuro-endocrine aspects of PCOS and advances in PCOS animal models.
Prepubertal Neuronal Networks in PCOS Suzanne M. Moenter, PhD—University of Michigan
In Vivo LH Pulses and Brain Gene Expression in a Letrozole PCOS Mouse Model Alexander S. Kauffman, PhD—University of California San Diego
Androgen and Progesterone Regulation of LH Secretion in PCOS Women Christopher R. McCartney, MD—University of Virginia School of Medicine
(S) Normal Spermatogenesis Is Critical for Reproductive Function (9:15 AM–10:45 AM) Chair: Christopher B. Geyer, PhD—East Carolina University. Despite reproductive longevity in males, we are only beginning to understand mechanisms of normal spermatogenesis, and how the genomics of the germline are altered with age, potentially impacting reproductive outcomes. This session will review mechanisms in spermatogonial stem cell fate, including DNA methylation, that are critical for spermatogenesis.
Spermatogonial Stem Cell Therapies for Male Infertility Orwig Kyle, PhD—University of Pittsburgh
The Human Testis Transcriptional Cell Atlas Bradley R. Cairns, PhD—Huntsman Cancer Institute
Age-Related Alterations in the Genetics and Genomics of the Male Germ Line Dolores J. Lamb, PhD, HCLD—Weill Cornell Medical College
(S) Shining Light: Seasonal Animals Translate Light Cues into Hormone or Metabolic Signals (4:00 PM–5:30 PM) Chair: Paul R. Le Tissier, PhD—University of Edinburgh Seasonal animals have dramatic shifts in many aspects of physiology, from reproduction to metabolism and herbal regulation. The mechanisms underlying these physiological changes are also likely to apply to non-seasonal animals, such as humans, and provide targets for therapeutic intervention. This symposium will describe the mechanisms underlying the translation of light cues to season changes at the level of the pituitary and hypothalamus, the signaling pathways which mediate peripheral effects on metabolism and the hypothalamic changes which mediate changes in metabolism and the state of torpor. This symposium will appeal to those interested in the basic understanding of hypothalamic regulation of a number of endocrine axes, as well as showing how basic animal research can impact on identifying targets for clinical therapy.
Timing Annual Cycles in the Pituitary Andrew S. I. Loudon, PhD—University of Manchester
Actions of FGF21 in Metabolism and Appetite Francis J. Ebling, PhD—University of Nottingham
Pituitary Angiogenic Mechanisms Underlie Seasonal Adaptation to a Changing Environment Domingo J. Tortonese, DVM, PhD, DVSc—Faculty of Health Sciences, University of Bristol
(S) Non-Canonical Actions of Gonadotropin Hormones (4:00 PM–5:30 PM) Chair: T Rajendra Kumar, PhD—University of Colorado at Denver. The gonadotropin hormones and their receptors are key components of the classis HPG axis. However, their utility in non-gonadal sites have been debated. This session presents novel non-gonadal roles of gonadotropins, updates on their role in distinct cancers and novel actions of this hormone/receptor system in canonical gonadal functions.
Spermatogenesis without Testosterone Ilpo T. Huhtaniemi, MD, PhD—Imperial College London
FSH Actions in Adipose Tissue Mone Zaidi, MD, PhD—Mount Sinai School of Medicine
Roles of Extra-Ovarian FSH Receptors in Pregnancy Deborah L. Segaloff, PhD—Carver College of Medicine - University of Iowa
(S) Novel Therapeutic Targets for Preterm Labor (4:00 PM–5:30 PM) Chair: Mark R. Johnson, MBBS, PHD, MRCP, MRCOG—Imperial College School of Medicine Currently, there are limited options and few new tocolytic drugs under development to prevent preterm labor. We need new tocolytic drugs, but how do we approach the problem? This session will discuss models, molecules, and targets in the search for new options.
An Overview of Preterm Labor and Its Prevention David M. Olson, PhD—University of Alberta
Cellular Models for Preterm Labor Donna M. Slater, PhD—University of Calgary
New Approaches to Designing Tocolytic Drugs William Lubell, PhD—Université de Montréal
(S) Endocrine Disrupting Chemicals from Top to Bottom (9:15 AM–10:45 AM) Chair: Vasantha Padmanabhan, MS, PhD—University of Michigan. This Symposium addresses the diverse effects of EDCs on the brain, adipocyte differentiation, and development in the male reproductive tract.
EDCs and Developmental Programming of Brain and Behavior Andrea C. Gore, PhD—University of Texas at Austin
Estrogen Effects of EDCs Ana M. Soto, MD—Tufts University School of Medicine
Aberrant Transcriptional and Epigenetics in the Mouse Seminal Vesicles Following Developmental DES Exposure Kenneth S. Korach, PhD—National Institute of Environmental Health Sciences
Multigenerational Effects of Endocrine Disrupting Chemicals on Behavior Emilie F. Rissman, PhD—North Carolina State University
(S) Kinase Signaling in Ovarian Development (11:45 AM–1:15 PM) Chair: Stephanie A. Pangas, PhD—Baylor College of Medicine. Growth factor and cytokine signaling are essential elements of ovarian follicle development, ovulation, and the function of the corpus luteum. This session will provide state of the art updates on the roles of these factors.
Endocrine Disruption in Follicle Development Aileen Keating, PhD—Iowa State University
Cytokines in the Primate Ovary Jon D. Hennebold, PhD—Oregon National Primate Research Center
Cytokine Expression and Action in the Corpus Luteum John S. Davis, PhD—University Nebraska Medical Center
EGF Signaling and Oocyte Maturation Robert B. Gilchrist, DSc—University of New South Wales