Reproductive Endocrinology at ENDO 2019


Our popular Basic Science Pathways are back and have been enhanced to ensure your meeting experience focuses in on the topic area you need. These special “meeting within a meeting” tracks integrate focused discussions, poster sessions, and networking opportunities providing you with an ideal way to surround yourself with the latest research. View the Reproductive Endocrinology Pathway below and add to your meeting itinerary.

Each track will offer electronic poster previews to help facilitate the viewing of the top scoring abstracts within each topic and receptions to be held at the end of each program.

Plenary(PL) | Session(S) | Educational(E) | Oral Abstracts(O) | Poster Sessions(P) | Reception(R)

Friday, March 22, 2019

(S) Androgen Excess and PCOS Update Meeting: Development of PCOS Related Health Concerns in Offspring and Their Potential Transfer across Generations (8:00 AM–5:30 PM)

Speakers at this one-day, topic-focused meeting, including selected oral presenters from submitted abstracts, will tackle new and emerging understanding of the potential role for intrauterine environment in the reproductive, psychiatric, and metabolic disturbances in offspring of women with polycystic ovary syndrome (PCOS) using human data and relevant animal models. Presentations include:

  • Implications of Polycystic Ovary Syndrome for Pregnancy and for the Health of Offspring
  • Intergenerational Associations of Chronic Disease and Polycystic Ovary Syndrome
  • Polycystic Ovary Syndrome Is Associated with Adverse Mental Health and Neurodevelopmental Outcomes
  • Does Maternal Androgen Exposure and Diet-Induced Obesity Increase the Susceptibility of Transgenerational Disease?

The meeting will finish with a debate and audience discussion of the motion: "Is maternal metabolic disease the risk factor for intergenerational transmission of PCOS?"

Saturday, March 23, 2019

Basic Science Pathways

(PL) Whole Genome Approaches to Unraveling Diseases (8:00 AM–9:30 AM)

  • President's and Chair Announcements; Award Presentations
    Susan J. Mandel, MD, MPH—University of Pennsylvania
  • Translating Whole Genome Data to Disease
    Francis S. Collins, MD, PhD—National Institutes of Health

  • (S) Maternal Fetal Interactions for Healthy Gestation (9:45 AM–11:15 AM)
    Chair: Jennifer J. Adibi, MPH, ScD—University of Pittsburgh.
    A view of the events of pregnancy from an endocrine view with an eye toward translation of basic information to clinical practice.

    • Endometrial Renewal and Receptivity
      Linda C. Giudice, MD, PhD—University of California, San Francisco
    • Fetal-Maternal Signaling in the Timing of Birth
      Carole R. Mendelson, PhD—University Texas Southwestern Medical Center
    • Molecular Mechanisms Regulating Uterine Receptivity
      Francesco J. DeMayo, PhD—National Institute of Environmental Health Sciences

    (O) Oral Abstracts: Reproductive Endocrinology (11:30 AM–1:00 PM)
    Learn and engage with the authors of the top submitted abstracts.

    (P) Poster Session: Reproductive Endocrinology (1:00 PM–3:00 PM)
    View and discuss submitted posters on reproductive endocrinology.

    (PL) Gene Editing and Stem Cells: Using Reproductive Technology for Early Disease Treatment (3:00 PM–4:00 PM)

    • President's Announcements and Awards
      Susan J. Mandel, MD, MPH—University of Pennsylvania
    • Repair of Mitochondrial DNA in Embryos
      Juan Carlos Izpisua Belmonte, PhD—Salk Institute
    • Genomic Imprinting and Epigenetic Gene Regulation
      Marisa Bartolomei, PhD—University of Pennsylvania

    (S) Vitamin D and Health Across the Lifespan (4:15 PM–5:45 PM)
    Chair: John S. Adams, MD—UCLA Dept Orthopaedic Surgery.
    There is compelling data about antenatal and early post-natal effects of vitamin D on placental function, fetal outcomes, and on autoimmunity. This session will address non-classical effects of vitamin D. The first two speakers, one basic, one clinical, will address these early effects on placenta and fetal outcomes and the last would give an overall perspective.

    • Maternal Vitamin D and Neonatal Immunity
      Catherine M. Hawrylowicz, PhD—Kings College London
    • The Influence of Vitamin D on Autoimmune Disease Outcomes in the VDAART Study
      Scott T. Weiss, MD, MS—Brigham and Women's Hospital
    • Vitamin D and Autoimmunity
      Chantal Mathieu, MD, PhD—KU Leuven

    (S) Neena B. Schwartz Memorial Symposium: TGF-β Signaling in the Ovary and Uterus (4:15 PM–5:45 PM)
    Chair: Teresa K. Woodruff, PhD—Northwestern University
    This session will bring together disparate studies of the role of TGF-β signaling in female reproductive events.

    • Nodal in Embryo Implantation
      Daniel Dufort, PhD—McGill University
    • TGF-beta Signaling in Uterine Function and Disease: Insights from Genetically Modified Mouse Models
      Qinglei Li, PhD—Texas A&M University
    • Transforming growth factor-ß family and its modulating microRNAs in placental development and uterine spiral artery remodeling
      Chun Peng, MS, PhD—York University

    (S) The Role of Lactogens in Signaling the Mother and Fetus (4:15 PM–5:45 PM)
    Chair: Carmen Clapp, PhD—Universidad Nacional Autonoma de Mexico.
    Circulating prolactin and prolactin-like proteins are dramatically increased during pregnancy and have key roles in modifying a range of systems which are essential for support of the fetus, preparing the mother for the demands of lactation and programming of offspring. This symposium will include speakers who are dissecting the role prolactin and related proteins of both pituitary and placental origin in key processes which are essential for optimal offspring function. These include the role of these proteins in maternal behavior and altered metabolism the differential roles of each of the various placental lactogens and how placental lactogens mediate fetal programming. This symposium will be of interest to basic scientists and clinicians with interests in the importance of maternal physiology in the health of offspring.

    • Prolactin in Pregnancy and How It Affects Maternal Metabolism and Behavior
      David R. Grattan, PhD—University of Otago
    • Epigenetics in the Placenta and Regulation of Placental Lactogens
      Rosalind M. John, PhD—Cardiff University
    • Maternal Obesity and Human Placental Lactogen Gene Chromosomal Architecture and Expression
      Peter A. Cattini, PhD—University of Manitoba

    (R) Networking Reception: Reproductive Endocrinology (5:45 PM–7:00 PM)
    Network with your colleagues and leaders in the field. Click here to RSVP.

    Sunday, March 24, 2019

    (E) Meet-the-Scientist: CRISPR, RNAi, and shRNA Screens (9:15 AM–10:00 AM)
    A discussion with Christopher K. Glass, MD, PhD—University of California San Diego

    (S) Neuroendocrine Regulation in PCOS (9:15 AM–10:45 AM)
    Chair: Daniel J. Bernard, PhD—McGill University
    Polycystic ovary syndrome (PCOS) is a major endocrine disorder affecting women of reproductive age globally. This session will address neuro-endocrine aspects of PCOS and advances in PCOS animal models.

    • Prepubertal Neuronal Networks in PCOS
      Suzanne M. Moenter, PhD—University of Michigan
    • In Vivo LH Pulses and Brain Gene Expression in a Letrozole PCOS Mouse Model
      Alexander S. Kauffman, PhD—University of California San Diego
    • Androgen and Progesterone Regulation of LH Secretion in PCOS Women
      Christopher R. McCartney, MD—University of Virginia School of Medicine

    (S) Normal Spermatogenesis Is Critical for Reproductive Function (9:15 AM–10:45 AM)
    Chair: Christopher B. Geyer, PhD—East Carolina University.
    Despite reproductive longevity in males, we are only beginning to understand mechanisms of normal spermatogenesis, and how the genomics of the germline are altered with age, potentially impacting reproductive outcomes. This session will review mechanisms in spermatogonial stem cell fate, including DNA methylation, that are critical for spermatogenesis.

    • Spermatogonial Stem Cell Therapies for Male Infertility
      Orwig Kyle, PhD—University of Pittsburgh
    • The Human Testis Transcriptional Cell Atlas
      Bradley R. Cairns, PhD—Huntsman Cancer Institute
    • Age-Related Alterations in the Genetics and Genomics of the Male Germ Line
      Dolores J. Lamb, PhD, HCLD—Weill Cornell Medical College

    (S) Shining Light: Seasonal Animals Translate Light Cues into Hormone or Metabolic Signals (4:00 PM–5:30 PM)
    Chair: Paul R. Le Tissier, PhD—University of Edinburgh
    Seasonal animals have dramatic shifts in many aspects of physiology, from reproduction to metabolism and herbal regulation. The mechanisms underlying these physiological changes are also likely to apply to non-seasonal animals, such as humans, and provide targets for therapeutic intervention. This symposium will describe the mechanisms underlying the translation of light cues to season changes at the level of the pituitary and hypothalamus, the signaling pathways which mediate peripheral effects on metabolism and the hypothalamic changes which mediate changes in metabolism and the state of torpor. This symposium will appeal to those interested in the basic understanding of hypothalamic regulation of a number of endocrine axes, as well as showing how basic animal research can impact on identifying targets for clinical therapy.

    • Timing Annual Cycles in the Pituitary
      Andrew S. I. Loudon, PhD—University of Manchester
    • Actions of FGF21 in Metabolism and Appetite
      Francis J. Ebling, PhD—University of Nottingham
    • Pituitary Angiogenic Mechanisms Underlie Seasonal Adaptation to a Changing Environment
      Domingo J. Tortonese, DVM, PhD, DVSc—Faculty of Health Sciences, University of Bristol

    (S) Non-Canonical Actions of Gonadotropin Hormones (4:00 PM–5:30 PM)
    Chair: T Rajendra Kumar, PhD—University of Colorado at Denver.
    The gonadotropin hormones and their receptors are key components of the classis HPG axis. However, their utility in non-gonadal sites have been debated. This session presents novel non-gonadal roles of gonadotropins, updates on their role in distinct cancers and novel actions of this hormone/receptor system in canonical gonadal functions.

    • Spermatogenesis without Testosterone
      Ilpo T. Huhtaniemi, MD, PhD—Imperial College London
    • FSH Actions in Adipose Tissue
      Mone Zaidi, MD, PhD—Mount Sinai School of Medicine
    • Roles of Extra-Ovarian FSH Receptors in Pregnancy
      Deborah L. Segaloff, PhD—Carver College of Medicine - University of Iowa

    (S) Novel Therapeutic Targets for Preterm Labor (4:00 PM–5:30 PM)
    Chair: Mark R. Johnson, MBBS, PHD, MRCP, MRCOG—Imperial College School of Medicine
    Currently, there are limited options and few new tocolytic drugs under development to prevent preterm labor. We need new tocolytic drugs, but how do we approach the problem? This session will discuss models, molecules, and targets in the search for new options.

    • An Overview of Preterm Labor and Its Prevention
      David M. Olson, PhD—University of Alberta
    • Cellular Models for Preterm Labor
      Donna M. Slater, PhD—University of Calgary
    • New Approaches to Designing Tocolytic Drugs
      William Lubell, PhD—Université de Montréal

    Monday, March 25, 2019

    (E) Meet-the-Scientist: Big Data and Bioinformatics for Biologists (9:15 AM–10:00 AM)
    A discussion with Debyani Chakravarty, PhD—Memorial Sloan Kettering Cancer Center

    (S) Endocrine Disrupting Chemicals from Top to Bottom (9:15 AM–10:45 AM)
    Chair: Vasantha Padmanabhan, MS, PhD—University of Michigan.
    This Symposium addresses the diverse effects of EDCs on the brain, adipocyte differentiation, and development in the male reproductive tract.

    • EDCs and Developmental Programming of Brain and Behavior
      Andrea C. Gore, PhD—University of Texas at Austin
    • Estrogen Effects of EDCs
      Ana M. Soto, MD—Tufts University School of Medicine
    • Aberrant Transcriptional and Epigenetics in the Mouse Seminal Vesicles Following Developmental DES Exposure
      Kenneth S. Korach, PhD—National Institute of Environmental Health Sciences
    • Multigenerational Effects of Endocrine Disrupting Chemicals on Behavior
      Emilie F. Rissman, PhD—North Carolina State University

    (E) Meet-the-Scientist: Single-Cell Sequencing (2:00 PM–2:45 PM)
    A discussion with Aviv Regev, PhD—Broad Institute

    Tuesday, March 26, 2019

    (S) Kinase Signaling in Ovarian Development (11:45 AM–1:15 PM)
    Chair: Stephanie A. Pangas, PhD—Baylor College of Medicine.
    Growth factor and cytokine signaling are essential elements of ovarian follicle development, ovulation, and the function of the corpus luteum. This session will provide state of the art updates on the roles of these factors.

    • Endocrine Disruption in Follicle Development
      Aileen Keating, PhD—Iowa State University
    • Cytokines in the Primate Ovary
      Jon D. Hennebold, PhD—Oregon National Primate Research Center
    • Cytokine Expression and Action in the Corpus Luteum
      John S. Davis, PhD—University Nebraska Medical Center
    • EGF Signaling and Oocyte Maturation
      Robert B. Gilchrist, DSc—University of New South Wales

    Please see your other Basic Science Pathways: Nuclear Receptors and Gene Regulation and Neuroendocrinology