Silvia Corvera, Akhila Rajan, Kristy L Townsend, Farnaz Shamsi, Jun Wu, Katrin J Svensson, Lori M Zeltser, Sheila Collins, Tânia Reis, Yu-Hua Tseng, Laurie J Goodyear
Endocrine Reviews, First published online September 11, 2025, bnaf032
https://doi.org/10.1210/endrev/bnaf032
Adipose tissue has emerged as a central regulator of human physiology, with its dysfunction driving the global rise in obesity-associated diseases, such as type 2 diabetes, cardiovascular and liver diseases, and several cancers. Once thought to be inert, adipocytes are now recognized as dynamic, responsive cells essential for energy homeostasis and interorgan communication, including the brain. Distinct adipose depots support specialized functions across development, sex, and aging. Technologies like single-cell RNA sequencing are unraveling depot-specific mechanisms, with the potential of identifying new therapeutic targets. This review highlights major scientific advancements leading to our current appreciation of the pivotal role of adipose tissue in health and disease. Many key discoveries in this field have been catalyzed by National Institutes of Health funding, particularly through the National Institute of Diabetes, Digestive and Kidney Diseases, now celebrating its 75th anniversary.
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