Endocrine Reviews Journal Article

Sex Differences in the Hypocretin/Orexin System

January 11, 2022
 

Xiao-Bing Gao and Tamas L Horvath
Endocrine Reviews, First published online November 18, 2021, bnab042
https://doi.org/10.1210/endrev/bnab042

Abstract

The hypocretin/orexin (Hcrt/Orx) system in the perifornical lateral hypothalamus has been recognized as a critical node in a complex network of neuronal systems controlling both physiology and behavior in vertebrates. Our understanding of the Hcrt/Orx system and its array of functions and actions has grown exponentially in merely 2 decades. This review will examine the latest progress in discerning the roles played by the Hcrt/Orx system in regulating homeostatic functions and in executing instinctive and learned behaviors. Furthermore, the gaps that currently exist in our knowledge of sex-related differences in this field of study are discussed.

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