Adipocyte VDR Prevents Hepatic Steatosis

Tao Tao, Margaret M Kobelski, Vaibhav Saini, Marie B Demay
Endocrinology, Volume 163, Issue 2, February 2022, bqab249
https://doi.org/10.1210/endocr/bqab249

Abstract

Risk factors for nonalcoholic hepatic steatosis include obesity and vitamin D deficiency which commonly coexist. Thus, the role of vitamin D signaling in the prevention of hepatic steatosis in the absence of obesity or a “Western” high-fat diet is unclear. These studies were performed to address the role of the adipocyte vitamin D receptor (VDR) in the prevention of hepatic steatosis in mice fed a chow diet containing 5% fat by weight.

Female mice with adipocyte VDR ablation (Adipoq-Cre; VDR^flox/flox) exhibited a mild increase in weight gain at age 70 days, accompanied by an increase in visceral white adipose tissue (VAT) weight. While they did not exhibit evidence of hepatic inflammation or fibrosis, an increase in hepatic lipid content was observed. This was accompanied by an increase in the hepatic expression of genes involved in fatty acid transport and synthesis, as well as fatty acid oxidation. Markers of hepatic inflammation and fibrosis were unaffected by adipocyte VDR ablation. Consistent with the increase in VAT weight in the Adipoq-Cre; VDR^flox/flox mice, higher levels of transcripts encoding adipogenesis-related genes were observed in VAT.

In contrast to other models of impaired vitamin D signaling studied in the setting of a high-fat or “Western” diet, the Adipoq-Cre; VDR^flox/flox mice do not exhibit hepatic inflammation or fibrosis. These findings suggest that the adipocyte VDR regulates hepatic lipid accumulation, but in the absence of obesity or a high-fat diet, is not required to prevent hepatic inflammation or fibrosis.

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