Endocrinology Journal Article

Endocrinology of ACE2 and COVID-19

September 07, 2020
 

Eric Lazartigues, Mirza Muhammad Fahd Qadir, Franck Mauvais-Jarvis
Endocrinology, Volume 161, Issue 9, September 2020, bqaa108
https://doi.org/10.1210/endocr/bqaa108

Abstract

The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.

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