Endocrinology Journal Article

Mitochondrial Dysfunction and Ovarian Aging

January 12, 2020
 

Işıl Kasapoğlu and Emre Seli
Endocrinology, Volume 161, Issue 2, February 2020, bqaa001
https://doi.org/10.1210/endocr/bqaa001

Abstract

As women delay childbearing because of demographic and socioeconomic trends, reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent causes of infertility. Age-related decline in fertility is characterized by both quantitative and qualitative deterioration of the ovarian reserve. Importantly, disorders of aging are frequently associated with mitochondrial dysfunction, as are impaired oogenesis and embryogenesis. Ongoing research explores the role of mitochondrial dysfunction in ovarian aging, and potential ways to exploit mitochondrial mechanisms to slow down or reverse age-related changes in female gonads.

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