Neuronal and Adipose Androgenic Gateways to PCOS

David H Abbott, Jon E Levine, Daniel A Dumesic
Endocrinology, Volume 161, Issue 8, August 2020, bqaa095
https://doi.org/10.1210/endocr/bqaa095

Introduction

The common hyperandrogenic, subfertile, and obesogenic polycystic ovary syndrome (PCOS) takes approximately 2 years to diagnose, often after several changes of physicians. Such delayed care delivers symptom relief but provides no cure. Progress toward a cure and timely clinical intervention, however, has been hindered by a scarcity of animal models that reliably replicate PCOS. Several PCOS animal models, nevertheless, implicate hyperandrogenism, likely acting through the androgen receptor, as a common denominator for PCOS etiopathogenesis, involving genetic, epigenetic, and developmental interactions. Consistent with this notion, flutamide treatment of women with PCOS can normalize episodic release of progesterone-regulated pituitary luteinizing hormone and likely hypothalamic gonadotropin-releasing hormone, inducing ovulation.

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