Endocrinology Journal Article

Pituitary Complications of Checkpoint Inhibitor Use

October 08, 2024
 

Natalia Chamorro-Pareja, Alexander T Faje, Karen K Miller
Endocrinology, Volume 165, Issue 9, September 2024, bqae084
https://doi.org/10.1210/endocr/bqae084

Abstract

Immune checkpoint inhibitors have revolutionized cancer therapy but are associated with a risk of endocrine immune-related adverse events, including pituitary complications. Autoimmune hypophysitis, traditionally a rare diagnosis, has become a more frequently encountered clinical entity with the emergence of antitumor immunotherapy. This mini-review aims to consolidate current knowledge, encompassing the epidemiology, pathophysiology, clinical presentation, diagnosis, and management of pituitary complications of immune checkpoint inhibitor use.

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