Endocrinology Journal Article

Roadblocks to Targeting Murine β Cells

August 10, 2020
 

Jennifer L Estall and Robert A Screaton
Endocrinology, Volume 161, Issue 8, August 2020, bqaa078
https://doi.org/10.1210/endocr/bqaa078

Introduction

The topic of which Cre-recombinase driver to use for gene targeting in pancreatic β cells comes up often around the bar at conferences. And these conversations last a long time. Challenges with the most commonly used tool for targeted gene recombination (Cre/Lox) plague the β cell field. With more than 20 lines generated to target these specialized endocrine cells, choice was never the problem.

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