Endocrinology Journal Article

Temperature as a Control of Obesity: Can We Target Thermogenesis?

September 12, 2019

Patricia Rivera, Julie A Chowen
Endocrinology, Volume 160, Issue 11, November 2019, Pages 2717–2718
https://doi.org/10.1210/en.2019-00613

Commentary

Obesity and its associated metabolic disorders have become one of the greatest health and economic problems of developed countries, and their prevalence is increasing not only in adults but also in children and adolescents. The past two decades have witnessed exponential growth in research dedicated to understanding metabolism and appetite control with the ultimate goal of procuring effective antiobesity drugs. It is now clear that genetic, physiological, developmental, environmental, and social causes are all intricately involved in the onset and perpetuation of the current obesity epidemic. Thus, as numerous processes and signaling mechanisms are implicated in the development and evolution of this complex disorder, it follows that the possible therapeutic targets are also numerous. Behavioral guidelines related to nutrition and physical exercise have been emphasized and implemented to an extent, and pharmacological advances have been made; however, to date these advances and interventions have not been successful in curtailing the obesity epidemic.

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