The Journal of Clinical Endocrinology and Metabolism Journal Article

Cytokine Response to Exercise

April 11, 2023
 

Thomas Goj, Miriam Hoene, Louise Fritsche, Patrick Schneeweiss, J├╝rgen Machann, Agnese Petrera, Stefanie M Hauck, Andreas Fritsche, Andreas L Birkenfeld, Andreas Peter, Martin Heni, Andreas M Niess, Anja Moller, Cora Weigert
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 4, 1 April 2023, Pages 865–875
https://doi.org/10.1210/clinem/dgac623

Abstract

Context

One acute bout of exercise leads to a rapid increase in the systemic cytokine concentration. Regular exercise might alter the cytokine response, in particular in beforehand untrained and obese individuals.

Objective

Using a proximity extension assay, we studied the effects of acute exercise as well as endurance training on a panel of 92 cytokines related to inflammation.

Methods

A total of 22 individuals (30 ± 9 years; peak oxygen uptake [VO2peak] 25.2 ± 4.2 mL/[kg × min]; body mass index [BMI] 31.7 ± 4.4) participated in an 8-week endurance exercise intervention. Blood samples were collected before and immediately after 30 minutes’ ergometer exercise at 80% VO2peak.

Results

Before and after the training intervention, 40 and 37 cytokines, respectively, were acutely increased more than 1.2-fold (Benjamini-Hochberg [BH]-adjusted P < .05). The exercise intervention did not change the acute increase in cytokines nor the resting cytokine levels, whereas fitness was improved and adiposity reduced. The increase in fitness led to a slight increase in power output when exercising at the same heart rate, which might explain the comparable increase in cytokines before and after the intervention. The largest acute increase was found for OSM, TGFA, CXCL1 and 5, and TNFSF14 (≥ 1.9-fold, BH-adjusted P < .001). The transcript levels of these proteins in whole blood were also elevated, particularly in the trained state. Only the acute increase in IL6 (1.3-fold) was related to the increase in lactate, confirming the lactate-driven secretion of IL6.

Conclusion

Our comprehensive proteomics approach detected several underexplored serum exerkines with up to now less understood function in the adaptation to exercise.

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