The Journal of Clinical Endocrinology and Metabolism Journal Article

Microbiome in PCOS and Related Metabolic Traits

March 15, 2021
 

Kreete Lüll, Riikka K Arffman, Alberto Sola-Leyva, Nerea M Molina, Oliver Aasmets, Karl-Heinz Herzig, Julio Plaza-Díaz, Stephen Franks, Laure Morin-Papunen, Juha S Tapanainen, Andres Salumets, Signe Altmäe, Terhi T Piltonen, Elin Org
The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 3, March 2021, Pages 858–871
https://doi.org/10.1210/clinem/dgaa848

Abstract

Context

Despite the gut microbiome being widely studied in metabolic diseases, its role in polycystic ovary syndrome (PCOS) has been scarcely investigated.

Objective

Compare the gut microbiome in late fertile age women with and without PCOS and investigate whether changes in the gut microbiome correlate with PCOS-related metabolic parameters.

Design

Prospective, case-control study using the Northern Finland Birth Cohort 1966.

Setting

General community.

Participants

A total of 102 PCOS women and 201 age- and body mass index (BMI)-matched non-PCOS control women. Clinical and biochemical characteristics of the participants were assessed at ages 31 and 46 and analyzed in the context of gut microbiome data at the age of 46.

Intervention

(s): None

Main outcome measure(s)

Bacterial diversity, relative abundance, and correlations with PCOS-related metabolic measures.

Results

Bacterial diversity indices did not differ significantly between PCOS and controls (Shannon diversity P = .979, unweighted UniFrac P = .175). Four genera whose balance helps to differentiate between PCOS and non-PCOS were identified. In the whole cohort, the abundance of 2 genera from Clostridiales, Ruminococcaceae UCG-002, and Clostridiales Family XIII AD3011 group, were correlated with several PCOS-related markers. Prediabetic PCOS women had significantly lower alpha diversity (Shannon diversity P = .018) and markedly increased abundance of genus Dorea (false discovery rate = 0.03) compared with women with normal glucose tolerance.

Conclusion

PCOS and non-PCOS women at late fertile age with similar BMI do not significantly differ in their gut microbial profiles. However, there are significant microbial changes in PCOS individuals depending on their metabolic health.

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