Cristiana Cipriani and John P Bilezikian
Journal of the Endocrine Society, Volume 5, Issue 3, March 2021, bvab003
https://doi.org/10.1210/jendso/bvab003
Hypoparathyroidism is a rare endocrine disorder whose clinical manifestations and complications involve the perturbation of several organs and systems that are specifically related to the target organs of parathyroid hormone (PTH). Chronic hypoparathyroidism is characterized by hypocalcemia and deficient PTH secretion. Levels are usually below detection limits of clinical assays for PTH. Hypoparathyroidism occurs most often as a complication of anterior neck surgery but can also occur as a genetic, autoimmune, or idiopathic disorder.
In the last decade, several studies have focused on the prevalence, natural history, and pathophysiology of hypoparathyroidism and its complications. This research has offered new insights into a disease with protean manifestations. Moreover, and similar to primary hyperparathyroidism, published observations from different geographical areas gain an advantage by comparing and contrasting the clinical profiles of hypoparathyroidism as they present around the world.
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