Journal of the Endocrine Society Journal Article

Ectopic Prolactin Secretion From a Uterine Leiomyoma

March 16, 2020
 

Saachi Sachdev, Maria Carolina Reyes, Peter J Snyder
Journal of the Endocrine Society, Volume 4, Issue 4, April 2020, bvaa035
https://doi.org/10.1210/jendso/bvaa035

Abstract

Ectopic hormone production is well recognized, but ectopic production of prolactin has been reported infrequently. We report here the case of a 47-year-old woman who had hyperprolactinemia (213–224 ng/mL) causing galactorrhea and hypogonadism. Cabergoline treatment, 1.0 mg twice a week, did not lower the prolactin level at all, but excision of a large uterine leiomyoma corrected the hyperprolactinemia and the hypogonadism. The excised leiomyoma tissue exhibited immunostaining for prolactin, confirming by this method for the first time that a uterine leiomyoma was the cause of hyperprolactinemia. This case illustrates the need to consider an ectopic source of prolactin in a patient who has hyperprolactinemia that is not associated with a large sellar mass and is completely resistant to cabergoline.

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