Association of OGTT-Curve Shape With Anthropometric, Metabolic, and Inflammatory Parameters in Healthy Adults

Lisa Sophie Fischer, Eva Kiesswetter, Beate Brandl, Thomas Skurk, Hans Hauner, Dorothee Volkert, Robert Kob
Journal of the Endocrine Society, Volume 9, Issue 6, June 2025, bvaf060
https://doi.org/10.1210/jendso/bvaf060

Abstract

Introduction

The shape of the oral glucose tolerance test (OGTT) curve is an early predictor of metabolic disturbances. In this study, we analyzed which parameters are associated with different OGTT-curve shapes (CS) in healthy middle-aged and older adults.

Methods

In the cross-sectional Enable Study, 354 participants were comprehensively phenotyped. Based on a 2-hour OGTT, CS was classified according to the presence (polyphasic) or absence (monophasic, mp) of a rise in plasma glucose of more than 4.5 mg/dL after the first decline of the plasma glucose level. Associations between CS and age, sex, anthropometric, metabolic, and inflammatory parameters were analyzed by binomial logistic regression.

Results

Curve shape was mp in 77.4% of the participants without age group difference, but a higher frequency was observed in men (89.3%) compared to women (65.5%, P < .001). The odds of mp CS increased with higher fasting GLP-1 (odds ratio [OR], 1.066; 95% CI, 1.006-1.133; P < .05) and 1-hour plasma glucose (OR, 1.054; 95% CI, 1.037-1.072; P < .001) and lower 2-hour plasma glucose (OR, 0.975; 95% CI, 0.959-0.992; P < .01).

Conclusion

In healthy adults, mp CS was widespread and associated with more unfavorable metabolic parameters. A higher fasting GLP-1 level was associated with an mp CS.

You may also like...