Clare J Lee, Huzhang Mao, Vivian T Thieu, Laura Fernández Landó, Melissa K Thomas
Journal of the Endocrine Society, Volume 7, Issue 5, May 2023, bvad056
https://doi.org/10.1210/jendso/bvad056
Tirzepatide is a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist approved for treatment of type 2 diabetes (T2D). SURPASS-1, a phase 3 trial of tirzepatide monotherapy in people with early T2D, enables evaluating effects of tirzepatide on pancreatic β-cell function and insulin sensitivity (IS) without other background antihyperglycemic medications.
Explore changes in biomarkers of β-cell function and IS with tirzepatide monotherapy.
Post hoc analyses of fasting biomarkers with analysis of variance and mixed model repeated measures.
Forty-seven sites in 4 countries.
Four hundred seventy-eight T2D participants.
Tirzepatide (5, 10, 15 mg), placebo.
Analyze biomarkers of β-cell function and IS at 40 weeks.
At 40 weeks, markers of β-cell function improved with tirzepatide monotherapy vs placebo with reductions from baseline in fasting proinsulin levels (49-55% vs −0.6%) and in intact proinsulin/C-peptide ratios (47-49% vs −0.1%) (P < .001, all doses vs placebo). Increases from baseline in homeostatic model assessment for β-cell function (computed with C-peptide) (77-92% vs −1.4%) and decreases in glucose-adjusted glucagon levels (37-44% vs +4.8%) were observed with tirzepatide vs placebo (P < .001, all doses vs placebo). IS improved as indicated by reductions from baseline in homeostatic model assessment for insulin resistance (9-23% vs +14.7%) and fasting insulin levels (2-12% vs +15%), and increases in total adiponectin (16-23% vs −0.2%) and insulin-like growth factor binding protein 2 (38-70% vs +4.1%) with tirzepatide vs placebo at 40 weeks (P ≤ .031, all doses vs placebo, except for fasting insulin levels with tirzepatide 10 mg).
As monotherapy for early T2D, tirzepatide achieved significant improvements in biomarkers of both pancreatic β-cell function and IS.
We provide our journal authors with a variety of resources for increasing the discoverability and citation of their published work. Use these tools and tips to broaden the impact of your article.
Read our special collections of Endocrine Society journal articles, curated by topic, Altmetric Attention Scores, and Featured Article designations.