an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2018–2020, focused on adrenal disease! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In Endocrine Reviews, Storbeck and coauthors detail advances in mostly mass spectrometry-based steroid metabolome analysis from serum or urine. These have yielded, sometimes in combination with artificial intelligence, important insights into a variety of disorders. Sherlock and coauthors discuss how adrenal incidentaloma has become a recognized and not uncommon diagnosis; although most patients can be reassured and discharged, endocrine workup is always required. Vaidya and colleagues discuss what they call the expanding spectrum of primary aldosteronism and its treatment: it appears to be commoner than once thought, with wide variation in severity.
In Journal of the Endocrine Society, Maharaj and coauthors describe an instance of compound heterozygosity between a common and a predicted “benign” variant in CYP11A1 causing primary adrenal insufficiency. Head and coauthors find evidence of longer survival in a small group of adrenocortical cancer patients treated with mitotane as well as pembrolizumab. Saiki and colleagues report the counter-intuitive finding that in primary aldosteronism, normal basal serum aldosterone levels predict a greater chance of treatment failure than higher levels (the authors also report better results from drug treatment than from adrenalectomy in patients with normal basal levels).
In JCEM, Skov and coauthors report that the risk of ischemic heart disease is increased in patients with autoimmune Addison disease (especially in women). Gerards et al. report their discovery that patients with primary aldosteronism often have autonomous cortisol secretion and that this is associated with impaired glucose metabolism. Gharzai and coauthors report that adjuvant radiotherapy extends the lives of patients after gross resection of adrenocortical cancer. Broersen and coauthors find that treatment for Cushing disease improved but did not normalize quality-of-life measures in all domains.
In Endocrinology, Bathon and colleagues report that PRKACA mutations, causative for Cushing syndrome, alter PKA substrate specificity as well as hamper binding to regulatory subunits. Kaikaew and coauthors report that corticosterone induces more severe insulin resistance in male than in female mice, and explain this as being a result of differences in the adaptation of adipose tissue. And Gehrand and colleagues describe striking effects of a long-acting anti-ACTH antibody in attenuating the ACTH-dependent adrenal steroidogenesis that occurs in response to hypoxia in newborn rats.
Published: July 2020
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, and The Journal of Clinical Endocrinology & Metabolism, so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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