an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2021–2022, focused on adrenal disease! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In an Expert Endocrine Consult in Journal of the Endocrine Society, Varlamov, Vila, and Fleseriu provide a discussion of the perioperative management and monitoring of patients undergoing transsphenoidal surgery for Cushing disease. Wentworth and Siragy discuss how cirrhosis may induce a relative cortisol deficiency during times of stress. Kelly and coauthors describe their study of diurnal patterns of adrenal and gonadal hormone levels after simulated shiftwork; they report that adrenal steroids, unlike gonadal steroids, display robust endogenous circadian regulation.
In JCEM, Genere at al. report that post-dexamethasone suppression test free cortisol measurements are diagnostically valuable in patients with optimal dexamethasone concentrations for a specific post-test total cortisol range. DeLozier and associates report that cosyntropin stimulation testing on the first day after unilateral adrenalectomy identifies adrenal-dependent hypercortisolism patients who are at risk for adrenal insufficiency, thus allowing selective glucocorticoid replacement. Braun and colleagues evaluate the Endocrine Society’s 2008 recommendation on who should be screened for Cushing syndrome, concluding that the recommendations are still valid in 2022.
In Endocrinology, Salehzadeh and coauthors report that in mice, lipopolysaccharide regulates glucocorticoid production by lymphoid organs, predominantly the spleen, as well as by the adrenal glands. Araki et al. describe a corticotroph marker for Cushing disease tumors and suggest that the phosphorylation generating it could be a novel target for pharmacological treatments. Warde and coauthors describe an additional mechanism for mitotane-induced cytotoxicity in adrenocortical carcinoma, lipid droplet breakdown, and activation of lipolysis.
In Endocrine Reviews, Nieman discusses the diagnosis of Cushing syndrome that results from an excess of adrenocorticotropin as well as the molecular changes that underlie the condition. Lerario, Mohan, and Hammer provide an update on the biology and genomics of adrenocortical carcinomas that highlights rationales for emerging therapies. And Miller and White provide a history of adrenal research that extends from ancient anatomy to contemporary molecular biology.
Published: December 2022
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, and The Journal of Clinical Endocrinology & Metabolism, so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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