an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2020–2022, focused on bone research! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In Journal of the Endocrine Society, Stone and colleagues discuss genetic variants in the fibroblast growth factor 21 signaling pathway that were associated in one patient with severe insulin resistance and pseudoacromegaly, manifesting in large stature resulting from impaired resistance to growth hormone. Al-Rayess and associates evaluate a hydrocortisone suspension for treatment of congenital adrenal hyperplasia in young children, achieving lower bone z-scores than tablets do because the suspension lowered androgen exposure. Namba et al. report that a phase 3/4 clinical trial of burosumab found the anti-fibroblast growth factor 23 antibody to be safe and effective in the treatment of X-linked hypophosphatemia.
Writing in Endocrinology, Khosla assesses evidence for follicle-stimulating hormone as a regulator of bone metabolism in humans. Sellars et al. report evidence that in mice, fibroblast growth factor 23 can defend against fetal hyperphosphatemia when there is maternal phosphate loading. Hirota and colleagues find that protein kinase A activation contributes to the bone growth-promoting effect of C-type natriuretic peptide in hypertrophic chondrocytes.
Kazemi and associates report in JCEM that women with polycystic ovary syndrome exhibit early signs of osteosarcopenia. Qu and colleagues report on a Mendelian randomization study indicating that serum parathyroid hormone (PTH) levels are inversely associated with bone mineral density and contribute to osteoporosis. Ward et al. find a high incidence of osteoporotic fractures and vertebral body re-shaping in children treated for rheumatic disorders with glucocorticoids.
In Endocrine Reviews, Martin and coauthors discuss PTH, concluding that its main role is in regulating calcium homeostasis; locally produced PTH-related protein appears to be more significant in regulating bone remodeling. Mills and colleagues describe the relationship between bone biology and reproductive signals beyond estrogens and androgens, including kisspeptin, prolactin, progesterone, inhibin, activin, and relaxin, among others. Ebeling et al. discuss secondary osteoporosis, which may resist conventional osteoporosis treatment and may result from endocrine, genetic, or chronic inflammatory conditions.
Published: February 2022
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, and The Journal of Clinical Endocrinology & Metabolism, so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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