an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2021, focused on endocrine neoplasia and cancer! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In Endocrine Reviews, Desai and colleagues review standard-of-care hormonal therapies now available for prostate cancer in its various clinical stages. Brandi and coauthors discuss discoveries about the genetic and molecular signatures of tumors associated with multiple endocrine neoplasia type 1 that support clinical trials of novel targeted therapies, along with advances in diagnostic tools and surgical approaches. Nölting et al. likewise discuss the “logical next step” of personalized therapy of inoperable or metastatic pheochromocytoma and paraganglioma based on genetic cluster-specific analysis.
In Endocrinology, Craig and associates report that a selective inhibitor of the expression cofactor HDAC6, ACY-241, blocks prolactin-stimulated gene expression involved in breast cancer and has therapeutic efficacy in in vitro and in vivo models of the disease. Piemonte and coauthors discuss the role of centrosome defects in breast cancer, including amplification, structural defects, and loss of primary cilium nucleation; these may instigate the tumor evolution that can lead to poor patient outcomes. And Massman and colleagues report that the post-translational modification O-GlcNAcylation has a central role in adrenocorticotropic hormone-secreting adenomas’ pathophysiology, including cellular proliferation and hypersecretion.
Writing in JCEM, Chen and associates report findings indicating that newly developed papillary thyroid cancer-derived organoids may be a preclinical model for studying clinical response to anticancer drugs in a personalized way or for developing new therapies. Chatterjee and colleagues report that in trial participants who were overweight and had prediabetes, vitamin D supplementation without selection for vitamin insufficiency did not decrease cancer incidence. Itoh and coauthors find that in a claims database, incidence of colorectal cancer increases with increased fasting plasma glucose levels.
Journal of the Endocrine Society authors Siddiqui and colleagues report the successful use of pasireotide, a second-generation somatostatin receptor ligand, in the treatment of three challenging cases of tumor-induced hypoglycemia. Gambelunghe and coauthors provide a favorable long-term follow-up report on the efficacy of ultrasound-guided laser ablation of benign thyroid nodules. And lastly, Uslar and associates describe a change in the clinical presentation of paraganglioma and pheochromocytoma over a multi-decadal interval, with a marked increase in incidental cases and milder symptoms.
Published: December 2021
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, and The Journal of Clinical Endocrinology & Metabolism, so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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