an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2020–2021, focused on immuno-endocrinology! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In a mini-review in Endocrinology, Huizinga and colleagues describe how the metabolically induced inflammation characteristic of obesity can dysregulate innate immune responses and contribute to organ injury in COVID-19. Mauvais-Jarvis and colleagues consider the effects of progesterone and estradiol on immune activity in the disease and evaluate the potential for their therapeutic use. Arambula and McCarthy discuss the “overwhelming evidence” for crosstalk between the immune and neuroendocrine systems that can shape developmental sex differences in the brain.
In Journal of the Endocrine Society, Kevin Miller et al. describe encouraging results in a small trial of single-agent multikinase inhibitors and checkpoint inhibitors as salvage therapy in advanced adrenal cortical carcinoma. Triolo and colleagues investigate islet autoimmunity and celiac autoimmunity in cotwins of probands with type 1 diabetes, finding evidence for environmental factors shared by type 1 diabetes discordant cotwins. Libianto and colleagues find that the neutrophil-lymphocyte ratio, a marker for inflammation, can also be a marker for severity of primary aldosteronism.
In Endocrine Reviews, Rasheed and Rayner outline the crucial importance of macrophage responses to pro-inflammatory and anti-inflammatory stimuli in different disease states, a field now termed “immunometabolism.” Marfil-Garza and coauthors evaluate the potential of regulatory T-cell-based therapies to overcome the immune barriers to islet transplantation as a curative therapy for type 1 diabetes. And So and associates review the “dynamic and nuanced” manifestations of autoantibodies in the progression of the disease, insights that are starting to benefit trials aiming to predict and prevent it.
Dhillon-Smith and colleagues report in JCEM on the prevalence of thyroid dysfunction and autoimmunity in women with a history of miscarriage or subfertility. Türe and coauthors describe a rare case of autoimmune-involved hypothalamitis with diabetes insipidus. Miñambres et al. describe two cases of autoimmune hypocalciuric hypercalcemia and propose an improved method of diagnosis based on antibodies to the calcium-sensing receptor.
Published: April 2021
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, and The Journal of Clinical Endocrinology & Metabolism, so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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