an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2020–2022, focused on immuno-endocrinology! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In Journal of the Endocrine Society, Park et al. demonstrate that under-carboxylated osteocalcin suppresses the tumor necrosis fact0r-alpha-induced inflammatory signaling pathway in myoblasts, a pathway that is important for muscle repair. Dosiou and Kossler discuss new treatment options for thyroid eye disease, an unpredictable inflammatory autoimmune condition. Al Ashi and colleagues report on immune-related endocrine events in metastatic cancer patients being treated with immune checkpoint inhibitors: Patients who had such events more often survived than those who did not.
In Endocrinology, Schjenken et al. report that, in mice, an obesogenic, high-fat diet alters the composition of seminal fluid so that it is less able to elicit a favorable, tolerogenic immune response in females at conception. Huang and associates elucidate a novel lipid-regulated signaling pathway that leads to inflammasome activation and pyroptosis in male mice and in humans. Moldenhauer and coauthors report that women using oral contraception have fewer regulatory T cells than naturally cycling women and a different regulatory T cell phenotype, although the differences were smaller than those between women and men.
In JCEM, Labadzhyan et al. report that endocrine-specific antibodies play an important role in the pathogenesis of endocrine-related adverse events occurring during immune checkpoint inhibitor treatment. Muir and colleagues find multiple distinct types of thyroid immune-related adverse events in melanoma patients undergoing such treatment. Satomura and coauthors report the likely involvement of insulin -fragment-specific interferon gamma-related immunoreactivity in the pathophysiology of some unprovoked ketosis-prone type 2 diabetes.
In Endocrine Reviews, Chakraborty et al. discuss the importance of estrogen receptor signaling in the immune system, a feature that might in part explain the more robust immune responses of females compared with males. And Gravholt and coauthors provide a comprehensive account of Turner Syndrome, a condition that causes an increased risk of autoimmune diseases, among other afflictions.
Published: August 2022
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, and The Journal of Clinical Endocrinology & Metabolism, so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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