an Endocrine Society Thematic Issue
Read our special collection of journal articles focused on men’s health research! Curation of the collection, based on articles published in 2021 to 2023, was guided by article views, Altmetric Attention Scores, and Featured Article designations.
In Journal of the Endocrine Society, Eriksson and colleagues report that castration of male mice induces metabolic remodeling and expression of fetal genes in the heart, as well as reduced cardiac performance during stress — a finding relevant to androgen deprivation therapy for prostate cancer. Giessner and associates describe a surprising sex difference in patients with type 2 diabetes: males have a blunted overnight fall in urinary epinephrine. Huang and coauthors report an association between body weight change and increased likelihood of abdominal aortic calcification in men.
In JCEM Case Reports, Sharma and Mehta describe the case of a phenotypic male with gynecomastia who was found to have genotype XX. Nichols et al. report on an adolescent male with an eating disorder diagnosis and generalized anxiety who, late in his illness, was recognized as having primary adrenal insufficiency. Ishii and colleagues describe a retroperitoneal solid pseudopapillary tumor, which is more commonly seen in women, mimicking a malignant adrenal tumor in a 67-year-old man.
In Endocrine Reviews, Desai and colleagues review the growing number of options for hormonal treatment of prostate cancer. Marzouni et al. discuss how the technologies of “organs on chips,” together with stem cells, may soon offer the possibility of having biological children to more men and women with reproductive failure or gamete dysgenesis. Federici and associates discuss therapeutic options for inducing puberty in hypogonadism, and note that gonadotropin treatment for pubertal induction in males with hypogonadotropic hypogonadism represents a good alternative to exogenous androgens.
In Endocrinology, El Kharraz and coauthors describe their finding that interactions between the carboxyterminal ligand-binding domain and the highly conserved 23FQNLF27 motif in the aminoterminal domain of the androgen receptor are not essential for normal functioning of the receptor in male mice, contrary to some expectations. Momb et al. report that substantial shifts in skeletal muscle function occur in male mice following acute exposures to low doses of a pharmacological estrogen receptor agonist and an androgen receptor antagonist — findings that, if applicable to humans, also have implications for the treatment of prostate cancer, among other diseases. Daugherty and associates find that legacy and emerging substitute polyfluoralkyl and perfluoroalkyl substances, aka “forever chemicals,” affect steroidogenesis in rats’ testes at nanomolar concentrations.
In JCEM, Rocca et al. report results from the largest study screening for androgen receptor gene variants in men of idiopathic infertile couples, finding that more than 80 percent of the men with gene variants had low sperm counts but high testosterone levels. Grossman and colleagues provide an “Approach to the Patient” article with recommendations for management of men over 50 with low serum testosterone. Green and coauthors compare and contrast the benefits to men’s cardiometabolic health of exercise programs and testosterone treatment.
Published: November 2023
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, The Journal of Clinical Endocrinology & Metabolism, and JCEM Case Reports so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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