an Endocrine Society Thematic Issue
Read our special collection of journal articles, published in 2020-2021, focused on thyroid disease! Curation of the collection was guided by Altmetric Attention Scores and Featured Article designations.
In Endocrinology, Bautista, Knippler, and Ringel review the structure and functions of group I and II p21-activated kinases, oncogenic proteins that regulate critical cell actions, focusing on their role in thyroid cancer. Gilbert, O’Shaughnessy, and Axelstad discuss the potential impact of thyroid-disrupting chemicals in the environment on two specific neurodevelopmental processes, and use these to highlight the difficulty of evaluating such chemicals to regulate them. Chen and colleagues analyze several types of interaction between COVID-19 and thyroid conditions, including possible effects of some treatments on the thyroid. And Wang et al. report on a Mendelian randomization study that finds clear causal effects of thyroid hormone levels on blood lipids, but none in the reverse direction.
In JCEM, Brancatella and associates describe an early case of subacute thyroiditis following SARS-CoV-2 infection. Dhillon-Smith and colleagues report on subclinical hypothyroidism thyroid peroxidase antibodies in women with a history of miscarriage or subfertility and propose a cutoff thyroid stimulating hormone level for identifying those who may need treatment. Chambers et al. use data from the UK Biobank to show that thyroid status affects gray matter volume in adults, particularly at the level of the cerebellum and the pallidum.
Also in JCEM, Moratalla-Navarro and colleagues describe co-morbidity networks for hypothyroidism, finding particularly strong connections for cancer of the thyroid and larynx and congenital anomalies, with some sex differences. And Marouli et al. use Mendelian randomization to find important linkages between thyroid function and stroke, as well as coronary artery disease.
In Journal of the Endocrine Society, Dosiou and Kossler provide an overview of the changing treatment landscape for thyroid eye disease, reviewing clinical guidelines and discussing trials of new biological therapies. Brancatella and colleagues describe the management of two forms of thyrotoxicosis that may develop following cancer treatment with checkpoint inhibitors, and Suzuki et al. document the clinical of course of euthyroid female patients positive for thyroid-stimulating hormone receptor antibody: They find that a significant proportion develop Graves’ disease.
And in Endocrine Reviews, Lane and colleagues review emerging therapies for Graves’ hypothyroidism, many of which specifically target the thyroid-stimulating hormone receptor.
Published: July 2021
It can be difficult to keep up to date in the rapidly evolving and expanding world of endocrine science. We curate topical collections of research from across our journals, Endocrine Reviews, Endocrinology, Journal of the Endocrine Society, and The Journal of Clinical Endocrinology & Metabolism, so that you can easily find and read recent, influential articles on the topics that interest you.
Selection in each Thematic Issue is guided by online metrics, including Altmetric Attention Scores, Featured Article designations, and identification of leading authors and key topics. Each month, we publish a new Thematic Issue online and work to highlight and promote endocrine science in the press, through email, on social media and across other distribution channels.
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