Nuclear Receptors and Signaling

November 05, 2020

These special “meeting-within-a-meeting” tracks integrate focused discussions, oral and poster abstract sessions, and networking opportunities to provide you with the latest research in dedicated topic areas. To view the full listing, please visit the program planner.

Classical and Orphan Receptors Throughout the Reproductive Lifespan

  • NR5A1 (Steroidogenic Factor 1) in the Developing Testis
    Pancharatnam Jeyasuria, PhD, Wayne State University, School of Medicine
  • Role(s) of ERRs in Breast Cancer
    Rebecca Riggins, PhD, Georgetown University
  • Endometriosis, Genetics, and Epigenetics
    Serdar Bulun, MD, Northwestern University

A Deep Dive Into Development and Cancer

  • Cytoskeletal Methylation: A New Cancer Target for the Epigenetic Machinery Outside the Nucleus
    Cheryl Walker, Baylor College of Medicine, Houston, TX, USA
  • Understanding Spermatogonial Stem Cells and Male Puberty at the Single-Cell and Genomic Level
    Bradley Cairns, PhD, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA

Meet the Scientist: Drugs, Steroids, and Cancer: Bridging the Worlds of Endocrinology, Metabolism, and Oncology

  • Faculty Nima Sharifi, MD, Cleveland Clinic
  • Moderator Kendall Nettles, PhD, Scripps Research Institute

Meet the Scientist: Examining the Chromatin Landscape

  • Epigenetic enzymes and transcriptional heterogeneity
    Trevor Archer, PhD, National Institute of Environmental Health Sciences
  • Moderator Carolyn Cummins, PhD, University of Toronto

Genomic Approaches to Understanding Hormone-Dependent Cancer and Resistance

  • Chair: Elaine T. Alarid, PhD, University of Wisconsin - Madison
  • Androgen Receptor Enhancers in Control of Prostate Cancer Development and Progression
    Wilbert Zwart, PhD, Netherlands Cancer Institute
  • Deconvoluting Signaling Between Cellular Subcompartments in the Tumor Microenvironment
    Wenyi Wang, PhD, The University of Texas MD Anderson
  • Integrating Next-Generation Sequencing Approaches to Investigate the Role of the Androgen Signaling Axis in Metastatic Prostate Cancer
    Felix Feng, MD, University of California, San Francisco

Presidential Plenary: The Impact of Basic Tissue Engineering and the Basic Biology of GPRCs in Emerging Therapies

  • Synthetic Hydrogels as Engineered Niches in Regenerative Medicine
    Andrés Garcia, PhD, Georgia Institute of Technology, Atlanta, Georgia, USA
  • Structural Insights Into G Protein Coupled Receptor Activation: Implications for Drug Discovery
    Brian Kobilka, MD, Stanford University, Stanford, CA, USA

Nuclear Receptor Genomics and Epigenomics

  • Chairs: Coralie Poulard, Norris Comprehensive Cancer Center, University of Southern California; and Evan Rosen, MD, PhD, Beth Israel Deaconess Medical Center
  • Nuclear Receptors, Chromatin Remodelers, and Pioneering Factors, and Transcriptional Heterogeneity in the Glucocorticoid Response
    Trevor Archer, PhD, National Institute of Environmental Health Sciences
  • Control of AR-mediated Transcriptional Program
    Jindan Yu, MD, PhD, Northwestern University
  • Molecular Mechanisms of Estrogen Receptor Enhancer Assembly and Function
    W. Kraus, PhD, University of Texas Southwestern Medical Center/li>

Mechanisms of Resistance to Hormone Therapy in Cancer

  • Molecular Subtypes of Prostate Cancer
    Christopher Barbieri, MD, PhD, Weill Cornell Medicine
  • WNT/Beta-Catenin Signaling in Prostate Cancer
    Susan Logan, PhD, New York University Langone Medical Center
  • Quieting the Estrogen Receptor for therapeutic benefit in ER+ breast cancer
    Ciara Metcalfe, PhD, Genentech, Inc.

Nuclear Receptor Signaling in Myeloid Cells

  • Nur77 (NR4A1) improves macrophage mitochondrial metabolism to resolve inflammation
    Carlie de Vries, PhD, Amsterdam University Medical Centers, University of Amsterdam
  • Niche-Specific Re-Programming of Epigenetic Landscapes Drives Myeloid Cell Diversity in NASH
    Christopher Glass, MD, PhD, University of California, San Diego
  • 11b-HSD1 in Myeloid Cells: Shaping Inflammation and Metabolism
    Karen Chapman, PhD, University of Edinburgh

Programming Steroid Signaling from the Membrane

  • Membrane Androgen Receptors in the Reproductive System
    Peter Thomas, PhD, The University of Texas at Austin
  • Progesterone Receptor Membrane Component (PGRMC) 1 and PGRMC2 in Female Reproductive Physiology
    James Pru, PhD, Washington State University
  • Membrane Androgen Receptors in Neurodegeneration
    Rebecca Cunningham, PhD, The University of North Texas Health Science Center/li>

Structural Determinants of Nuclear Receptor Function

  • Chair: Eric Ortlund, PhD, Emory University
  • Structural Proteomics (Technology: HDX): Hijacking Molecular Plasticity to Fine Tune Nuclear Receptor Signaling
    Patrick Griffin, PhD, The Scripps Research Institute
  • Translating Androgen Receptor Structure into Precision Medicines
    Eva Estébanez-Perpiñá, PhD, University of Barcelona
  • Structure of a Full-Length Monomeric Nuclear Receptor Reveals a Novel Inter-domain Interface in LRH-1
    Raymond D. Blind, PhD, Vanderbilt University Medical Center
  • Ligand-Induced Structural Dynamics of PPARγ Learned Through NMR
    Douglas Kojetin, PhD, Scripps Research Institute

Unconventional Actions of Estrogens and Estrogen Receptors

  • ERalpha Regulation of Mitochondrial Function and Metabolic Homeostasis
    Andrea Hevener, PhD, University of California, Los Angeles
  • Estrogen Action on Cardiac Myocytes and Fibroblasts
    Ellis Levin, MD, University of California, Irvine/VA Medical Center Long Beach
  • Regulation of Cellular and Systemic Metabolism by Estrogen Receptor Signaling
    Zeynep Madak Erdogan, PhD, University of Illinois at Urbana-Champaign

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