The goal of SHR 2024 is to present and discuss advances in steroid hormone action in biology and medicine, exploring their role in biology, chemistry, pharmacology, oncology, neurology, metabolism, cardiovascular biology and endocrinology. The conference will feature Plenary and Keynote Lectures, oral presentations and posters by prominent and emerging leaders as well as trainees in the field. Conference proceedings will be published in an international peer-reviewed journal. Sessions will cover (but are not limited to) the following topics:
- Cancer Biology and Therapeutics
- Cardiovascular Biology and Disease
- Neurobiology and Aging
- Metabolism and Comorbidities
- Molecular and Structural Biology of Steroid Receptors
- Immune System and Inflammation
- Systems Biology and Cell Signaling Networks
Schedule at a Glance
The schedule and tiles below are tentative. Check this page in leadup to our meeting for new updates on our program.
Tuesday, October 15th
- 6:00-8:00 PM MT - Informal reception/happy hour (Optional)
Wednesday, October 16, 2024
- 8:30-9:45 AM MT – Registration
- 9:45 AM MT – Welcome and Opening Remarks
- 10:00-11:00 AM MT – Opening Keynote
- Elucidation of the Mechanisms by Which Cells Recognize and Respond to Different Levels of Steroid Hormones to Elicit Different Biological Responses
- Faculty: Donald McDonnell, PhD
- 11:00 AM-12:00 PM MT – Programming & Reprogramming I: SRs in Health and Disease States
- Transcriptional and Epigenomic Programming of Homeostatic Macrophages
- Faculty: Inez Rogatsky, PhD
- Steroid Hormone Action in Endometrial Cancer
- Androgen Receptor Action in ER+ Breast Cancer – New Preclinical and Clinical Trial Findings
- Faculty: Jennifer Richer, PhD
- 1:00-3:00 PM MT – Feeding the Heart’s Desire: SRs in Cardiovascular Biology & Other High Places
- Proatherogenic Actions of Estrogen Receptors in Endothelium
- Faculty: Philip Shaul, MD
- Exploring Chemokine Receptors in the Genesis of Aldosterone and Mineralocorticoid Receptor-Induced Cardiovascular Injury
- Faculty: Thiago Bruder do Nascimento, PhD
- Steroid Hormones in Lung disease: Not All the Same
- Faculty: Gerry McElvaney, MD
- Crosstalk Between Steroid Hormones and Maf1: Implications for Cancer and Aging
- Faculty: Carol Sartorius, PhD
- Location, Location, Location…Spatial Biology of Hormone-Dependent Cancer Disparities
- Faculty: Zeynep Madak-Erdogan
- 3:00 PM MT – Poster Session
- 4:00-5:00 PM MT – Oral presentations from Abstracts
Thursday, October 17, 2024
- 8:30-9:45 AM MT – Networking
- 9:45 AM MT – Opening Remarks
- 10:00-11:00 AM MT – Scratching the Surface: SR Signaling Actions & Cell Fate
- Steroid Receptor Coactivator Complexes Regulate Breast Cancer Stem-Like Pathways in Therapy Resistant ER+ Breast Cancer
- Faculty: Julie Ostrander, PhD
- Testosterone Acts Through Membrane Protein GPRC6A to Cause Cardiac Phenotypes in Zebrafish Embryos
- Faculty: Daniel Gorelick, PhD
- Nuclear and Membrane Esr1 Signaling Are Essential for Early-Life Prostate Reprogramming by Estrogen
- 11:00 AM-12:00 PM MT –Through the Looking Glass: SR Structure & Functional Insights
- A Novel SERM Influences a Paracrine Factor Associated with Metastasis in Y537S ESR1 Breast Cancer Cells
- Faculty: Sean Fanning, PhD
- Oligomerization Changes Driven by Antagonist-to-Agonist Switch in MR
- Faculty: Diego Alvarez de la Rosa, PhD
- Structure-Informed Discovery of a Novel Nuclear Receptor Ligand Regulatory Mechanism
- Faculty: Douglas Kojetin, PhD
- 1:00-3:00 PM MT – Staying as Young as you Feel: SRs in Neurobiology, Metabolism & Aging
- The Metabolic and Behavioral Outcomes of a Preclinical Model of Estrogen Gender-Affirming Hormone Therapy
- Faculty: Troy Roepke, PhD
- Estrogenic Modulation of Neural Circuits that Control Energy Expenditure
- Faculty: Stephanie Correa, PhD
- Mineralocorticoid Receptor and Metabolic Diseases: A Closer Look at the Adipocyte
- Faculty: Massimiliano Caprio, MD, PhD
- Sensitizing B-cell Acute Lymphoblastic Leukemia to Treatment with Glucocorticoids
- Faculty: Miles Pufall, PhD
- 3:30-5:00 PM MT – Programming & Reprogramming II: Targeting SR Drivers of Altered Cellular States
- Understanding Lobular Breast Cancer as a Distinct Genomic Environment for Estrogen Receptor Activity
- Faculty: Matthew Sikora, PhD
- The Role of Obesity-Related Estrogens in Driving DNA Damage in the Breast Glands of BRCA1 and BRCA2 Mutation Carriers
- Faculty: Kristy Brown, PhD
- Combining AR and GR Antagonism in Prostate Cancer
- Faculty: Suzanne Conzen, MD
- Cancer Stem Cells Promote Therapy-Resistant ER+ Breast Cancer
Friday, October 18, 2024
- 8:30-9:15 AM MT – Breakfast
- 9:15 AM MT – Updates for the day/Meeting/Departure
- 9:30-10:30 AM MT – Hitting Above and Below the Belt: SRs in the Brain, Microbiome, and Reproductive Tract
- Time to Get Serious About Endometrial Cancer: Hormone-Dependent Disease Incidence and Mortality Rates are on the Rise!
- Faculty: Kimberly Leslie, MD
- Estrogens and the Gut Microbiome
- Promiscuous Behaviors of Nuclear Receptors Leads to Unique Transcriptomes in Human Cells and Animals
- Faculty: John Cidlowski, PhD
- 10:45-11:45 AM MT – Closing Keynote
- Broadening our Understanding of Estrogen Signaling in Female Physiology Beyond Breast Cancer
- Faculty: Holly Ingraham, PhD
- 11:45 AM MT - Awards Ceremony and Closing Remarks
