Keystone Symposia Mitochondrial Biology in Heart and Skeletal Muscle

Event Information

Meeting Type: Physical
Meeting Website: http://www.keystonesymposia.org/19J1
Dates: January 13 - 17, 2019
Location: Keystone, Colorado , United States
Intended Audience: Basic Scientist, Clinical Scientist, Early Career, In Training, Media, Physician or Advanced Practice Professional
Sponsor: Keystone Symposia on Molecular and Cellular Biology
Purpose: Education, Scientific
Number of CME Credits Offered: None

Topics: Aging, Cardiovascular Endocrinology, Diabetes Mellitus and Glucose Metabolism, Endocrine Disruption, Endocrine Genetics

Description: Mitochondria are highly dynamic and communicative organelles that regulate a variety of cellular processes including energy homeostasis, redox status, thermogenesis, and cell death via apoptosis. Mitochondria collaborate with a host of intracellular organelles including endoplasmic reticulum, peroxisomes, lysosomes, and nuclei to maintain metabolic homeostasis. Mitochondrial dysfunction disrupts metabolism and is thought to underlie cellular aging as well as the development of chronic diseases including type 2 diabetes, cardiovascular disease, heart failure, and aging-associated sarcopenia. Since mitochondria are enriched in cardiac and striated skeletal muscle, and since these tissues are critical in regulating whole body metabolism, insulin action, and locomotion, the objective of this meeting is to identify novel mechanisms controlling mitochondrial function and connect mitochondrial phenotypes with improved health and disease pathobiology. New insight into the biology and pathobiology of mitochondria will allow for the advance of therapeutic approaches that can be utilized to combat metabolic-related diseases associated with mitochondrial dysfunction. The compelling justification for this proposed meeting is the ongoing convergence of the fields of muscle metabolism and mitochondrial biology since our understanding of the precise molecular signaling that links mitochondrial function (biogenesis, fission-fusion-mitophagy dynamics, and mitochondrial genome integrity) with integrative metabolism and muscle action remains inadequate. These deficiencies in our fundamental knowledge of mitochondrial biology and the implications of this knowledge gap in the treatment and clinical care of common and rare mitochondrial diseases underpin the importance of this proposed Keystone conference. Moreover, opportunities for interdisciplinary interactions will be further enhanced by the concurrent meeting on “Mitochondria in Aging and Age-related Pathology,” which will share 2 keynote address and 2 plenary sessions. This conference will bring together investigators from diverse areas of integrative biology and metabolism who typically do not interact or attend the same research symposia. Thus, we anticipate that this meeting will foster the development of new collaborations, novel biological concepts, and innovative therapeutic strategies to harness the mitochondria for metabolic disease prevention.

Event Contact

Name: Attendee Services
Email: info@keystonesymposia.org
Phone: 970-262-1230 or 800-253-0685
Fax: 970-262-1525