Press Release

Automated drug delivery system combats low blood sugar after weight-loss surgery

New Orleans, LA March 25, 2019

A new automated drug delivery system can help prevent dangerously low blood sugar in patients who have undergone weight-loss surgery, according to a study to be presented Monday, March 25 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

An increasingly recognized complication of weight-loss surgery is low blood sugar, or post-bariatric hypoglycemia (PBH).  This condition can cause severe and debilitating low blood sugars after meals. Severe untreated hypoglycemia can cause seizures, loss of consciousness and death.

“Currently available treatments are not always effective for severely affected patients,” said lead researcher Christopher M. Mulla, M.D. of Joslin Diabetes Center in Boston, Mass. 

The researchers tested a new automated drug delivery system, similar to an insulin pump, which can detect when glucose levels are dropping quickly and deliver the hormone glucagon to patients to prevent low blood sugar.

The study included 12 participants (11 women and one man) with PBH who had undergone weight-loss surgery an average of eight years earlier; their average age was 52. They wore continuous glucose monitors and an automated pump system, filled with glucagon on one day and a placebo on the second day. Neither the participants nor the study team knew what the pumps contained. Participants were given a liquid meal on both days, and the device measured their glucose levels. The system automatically delivered up to two doses of glucagon or placebo if the monitor indicated the patient’s blood sugar was below a certain point.

Glucose levels were higher on the day they received glucagon than on the day they received a placebo. This indicates that the glucagon was effective at preventing severe low blood sugar, Mulla said. Side effects of the study medication were minimal and included temporary pain where the treatment entered the body.

“This study demonstrated that our glucagon automated delivery system can detect imminent low blood sugar and deliver a small dose of glucagon, yielding improvements in blood glucose levels after meals and reducing severe hypoglycemia in patients with PBH,” Mulla said. “Further research and development of this system will help treat this challenging disease.”

The team of researchers included engineers from Harvard Paulson School of Engineering and Applied Sciences led by Eyal Dassau, Ph.D., and the endocrinology team led by Mary Elizabeth Patti, M.D., at Joslin.

###

Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world’s oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions.

The Society has more than 18,000 members, including scientists, physicians, educators, nurses and students in 122 countries. To learn more about the Society and the field of endocrinology, visit our site at www.endocrine.org. Follow us on Twitter at @TheEndoSociety and @EndoMedia.


All Press Releases

Media Contacts

Colleen Williams Manager, Public Relations Phone: (202)-971-3611 cwilliams@endocrine.org

Jenni Glenn Gingery Associate Director, Communications and Media Relations Phone: (202)-971-3655 jgingery@endocrine.org

All News & Advocacy

Hill Event
Patient Resources

The Hormone Health Network

Hormone Health Network
From bench to bedside and all the stages in between, the Hormone Health Network is committed to supporting patient and public education.

From bench to bedside and all the stages in between, the Hormone Health Network is committed to supporting patient and public education.

Podcast

Endocrine News Podcast

EndocrineNewsPodcast
The Endocrine News podcast brings you the latest research and clinical advances from experts in the field, whether you are in your car, office, or out for a run.

The Endocrine News podcast brings you the latest research and clinical advances from experts in the field, whether you are in your car, office, or out for a run.

Bench to Bedside

Endocrine Society Journals

Research
Our top-ranked peer-reviewed journals are among the first to publish major developments and discovery milestones.

Our top-ranked peer-reviewed journals are among the first to publish major developments and discovery milestones.

Back to top
Short on time?

We'll come to you...

Get updates on the latest breakthroughs, clinical practice guidelines, and career development opportunities, straight to your inbox

Then take the next step: Set up your free website account and get exclusive access to even more great tools & content!