Alexandre Caron, BSc, MSc, PhD

November 03, 2020

Dr. Alexandre Caron is the Canada Research Chair in NeuroMetabolic Pharmacology. He obtained his PhD in Physiology-Endocrinology from Laval University in 2015. His graduate work focused on understanding the role of DEP domain-containing mTOR-interacting protein (DEPTOR) in energy, glucose and lipid homeostasis. His graduate research also involved the study of the molecular mechanisms regulating non-shivering thermogenesis in brown adipose tissue. After graduating, Dr. Caron joined the laboratory of Dr. Joel Elmquist (Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center) first as a Diabetes Canada Postdoctoral Fellow and then as a Banting Postdoctoral Fellow. His postdoctoral work aimed at understanding how the central leptin-melanocortin system controls adipose metabolic and endocrine functions. He also developed an arsenal of genetic models allowing the manipulation of key autonomic receptors. In 2019, Dr. Caron received the NIDDK K99/R00 Award to perform studies aimed at better understanding the sympathetic regulation of liver metabolism. Under the mentorship of Dr. Shawn Burgess (Center for Human Nutrition, University of Texas Southwestern Medical Center), he started combining mouse genetics, chemogenetics and stable isotope approaches to interrogate liver metabolism. In March 2020, he decided to relinquish this award to leave for home to the Great White North, where he was appointed a position of Assistant Professor in Pharmacy at Laval University and established his laboratory at the Quebec Heart and Lung Institute. His laboratory studies the pathophysiological mechanisms that alter brain-organs communication in metabolic diseases and aims to identify new molecular and pharmacological targets to improve energy and glucose metabolism. 


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