Society Letters

Endocrine Society Comments to EPA on Evaluation for Perchloroethylene (PCE)

July 06, 2020

To: Science Advisory Committee on Chemicals

"In conclusion, recent evidence published after the initiation of the PCE risk assessment demonstrates that PCE is an endocrine-disrupting chemical with the potential for widespread effects on endocrine sensitive tissues. In addition to neurological effects, these findings and other evidence of harms support an aggressive approach by EPA in mitigating harms due to PCE exposure. Final decisions by EPA should add additional safety margins, acknowledging the potential for mixture effects where PCE and related chemicals can act synergistically on the same pathway to produce adverse effects."

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