Clinical Practice Guideline

Evaluation and Treatment of Adult Growth Hormone Deficiency

June 01, 2011

Full Guideline: Evaluation and Treatment of Adult Growth Hormone Deficiency: An Endocrine Society Clinical Practice Guideline
JCEM June 2011

Mark E. Molitch, David R. Clemmons, Saul Malozowski, George R. Merriam, Mary Lee Vance

Objective:

The aim was to update The Endocrine Society Clinical Practice Guideline on Evaluation and Treatment of Adult Growth Hormone Deficiency (GHD) previously published in 2006.

Conclusions:

  • GHD can persist from childhood or be newly acquired.
     
  • Confirmation through stimulation testing is usually required unless there is a proven genetic/structural lesion persistent from childhood.
     
  • GH therapy offers benefits in body composition, exercise capacity, skeletal integrity, and quality of life measures and is most likely to benefit those patients who have more severe GHD.
     
  • The risks associated with GH treatment are low.
     
  • GH dosing regimens should be individualized.
     
  • The final decision to treat adults with GHD requires thoughtful clinical judgment with a careful evaluation of the benefits and risks specific to the individual.

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