Clinical Practice Guideline

Diagnosis and Treatment of Hyperprolactinemia

February 01, 2011

Full Guideline: Diagnosis and Treatment of Hyperprolactinemia: An Endocrine Society Clinical Practice Guideline
JCEM February 2011
Shlomo Melmed, Felipe F. Casanueva, Andrew R. Hoffman, David L. Kleinberg, Victor M. Montori, Janet A. Schlechte, John A. H. Wass

Objective:

The aim was to formulate practice guidelines for the diagnosis and treatment of hyperprolactinemia.

Introduction:

Testing for hyperprolactinemia is straightforward, owing to the ease of ordering a serum prolactin measurement. Accordingly, an evidence-based, cost-effective approach to management of this relatively common endocrine disorder is required.

Conclusions:

Practice guidelines are presented for diagnosis and treatment of patients with elevated prolactin levels.
These include:
- evidence-based approaches to assessing the cause of hyperprolactinemia
- treating drug-induced hyperprolactinemia
- and managing prolactinomas in nonpregnant and pregnant subjects
Indications and side effects of therapeutic agents for treating prolactinomas are also presented